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Prof Peter Hotez MD PhD Profile picture
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4 Jul, 4 tweets, 2 min read
"In comparison to SOC or placebo, IVM did not reduce mortality, length of stay or viral clearance in RCTs in COVID-19 patients with mostly mild disease. IVM did not have an effect on AEs or severe AEs. IVM is not a viable option to treat COVID-19 patients"
academic.oup.com/cid/advance-ar…
IVM is a great drug...for river blindness, strongyloidiasis, and scabies. Through my advocacy for mass/preventive Rx packages for neglected tropical diseases #NTDs in the early 2000s, my name is associated with providing IVM access to tens of millions of people living in poverty
But as an antiviral for clinical use, I've not seen compelling data, as the new paper I provided from Clinical Infectious Diseases - one of the top journals in our field - appears to confirm. Possibly there is an indication buried somewhere in there, and I'm open, but so far no
ebm.bmj.com/content/early/…

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More from @PeterHotez

Prof Peter Hotez MD PhD Profile picture
5 Jul
Many thanks @Boris_Sanchez for hosting me: we’re now seeing COVID surge this summer (as predicted) in areas where there’s the one-two punch of low vaccination and high delta. That’s why we’re seeing COVID re emerge in MO AK WY with more to follow. Image
Here’s my prediction @thedailybeast thedailybeast.com/covid-19-is-ri…
FYI to get timely information on where delta lives I go to @scrippsresearch the outbreak.info website
Read 4 tweets
Prof Peter Hotez MD PhD Profile picture
3 Jul
My colleagues say:
1. Vladimir Putin is the world’s wealthiest man.
2. He seeks to consolidate power by destabilizing Western Democracies.
3. He is clever, achieves gains through multiple disinformation approaches, including the GOP
4. This requires targeting US scientists
And (for full transparency) I present zero evidence for this, but it sounds plausible. Certainly from the language and aggression against me, family. But I think there’s enough there we should investigate
My opinion, and nothing more than opinion, is that there is a sinister link between Putin, Russia, and the disinformation targeting me other scientists, from far right members of our US Congress, and conservative news outlets
Read 4 tweets
Prof Peter Hotez MD PhD Profile picture
30 Jun
1/3 Many thanks ⁦@PoppyHarlowCNN⁩ ⁦@jimsciutto⁩ for hosting me, we spoke about the heterogeneity of COVID19 transmission across the nation, a consequence of 2 major factors: levels of vaccination and delta variant. Therefore CDC recs should be fine tuned accordingly
2/3 for example risk is especially high right now in Southern Missouri due to low vaccine coverage and high delta variant. CDC might consider presenting a “force of infection” map for the nation. So for example even if vaccinated, if I’m indoors I might still mask where FOI high
3/3 other important point, it’s not too late to get vaccinated, in areas of low vaccine coverage and delta that FOI will seek you out and you will become infected
Read 4 tweets
Prof Peter Hotez MD PhD Profile picture
29 Jun
1/3 The awful attacks against scientists from the extremists continue.
Here is what the Anderson et al paper in @NatureMedicine says..."the evidence shows that SARS-CoV-2 is not a purposefully manipulated virus…"
2/3 ...since we observed all notable SARS-CoV-2 features, including the optimized RBD and polybasic cleavage site, in related coronaviruses in nature, we do not believe that any type of laboratory-based scenario is plausible.
nature.com/articles/s4159…
Andersen, K.G., Rambaut, A., Lipkin, W.I. et al. The proximal origin of SARS-CoV-2. Nat Med 26, 450–452 (2020). doi.org/10.1038/s41591…
Read 4 tweets
Prof Peter Hotez MD PhD Profile picture
29 Jun
We've thrown intelligence at this for over a year, as I've said repeatedly: without a full year-long international scientific investigation, collecting virus/antibody samples across Central China, Hubei, I doubt we'll uncover the origins of COVID-19 wsj.com/articles/biden…
Until (on our side) we halt self-defeating obsessions with GOF and lab leaks conspiracies + convince the Chinese (on their side) to halt the obfuscation and allow a full-on "one health" year-long science project in Central China, I doubt we'll ever fully understand COVID origins
Here's what I said last month @thedailybeast thedailybeast.com/the-only-way-t…
Read 4 tweets
Prof Peter Hotez MD PhD Profile picture
27 Jun
This is madness:
There is no evidence SARS-2 CoV arose from GOF research
There is no evidence for a SARS-2 CoV lab leak
While not impossible, the most likely explanation remains that SARS-2 arose in China from natural origins
Just like SARS in 2002
thetimes.co.uk/article/the-ri…
We urgently need a full scientific investigation into COVID origins conducted in Central China, and led by a team of international and Chinese virologists, epidemiologists, and ecologists. This will require months of onsite work.
Otherwise we’ll never figure this out, and the world will remain susceptible to future coronavirus pandemics
Read 4 tweets

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