#cancer What if you can turn cancer cells into a 'Part-time' phenomenon, or even retire them altogether? A brilliant concept presented by Reiter and colleagues in their new peer-reviewed paper tells exactly how that can be achieved. tinyurl.com/5jdyrucf
1.Cancer cells use glucose as energy without involving electron transport in mitochondria for ATP. Instead, they use Warburg-type metabolisms that may use glycolysis and/or the pentose phosphate pathway to generate metabolites and substrates required for growth and proliferation
2. Recent discoveries show cancer cells can switch to using mitochondria OXPHOS similar to healthy cells for energy production. This switch apparently, can be mediated by the presence of higher melatonin that occurs naturally at night in most animals.
3. So if you use melatonin during the daytime as part of an anti-cancer therapy, converting cancer cell energy metabolism back to a healthy phenotype using mitochondria oxidative phosphorylation, you may just retire the cancer population from employment.
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#Immunity from SARS-CoV-2 mRNA vaccination verses infection are distinctly different. C19 patients had augmented interferon responses & effector T/ B cells, while vaccine recipients had high circulating memory T & B cells without interferon response [tinyurl.com/yc3wxbtz].
(2) Viruses modulate host genomes to enhance their own survival and replication. This has been going on for billions of years where both DNA and RNA viruses can capitalize on epitranscriptomic modifications to maximize viral gene expression [tinyurl.com/7s6uj4um].
(3) Viruses have shaped and built the genomes of organisms to survive for billions of years. [tinyurl.com/3kbcjcdv]. In human history, viruses like EBV is known to reprogram host metabolism/gene expression to proliferate and increase pathogenicity [tinyurl.com/4r799jm5]