Thread by @DorissLoh

#cancer What if you can turn cancer cells into a 'Part-time' phenomenon, or even retire them altogether? A brilliant concept presented by Reiter and colleagues in their new peer-reviewed paper tells exactly how that can be achieved. tinyurl.com/5jdyrucf

1.Cancer cells use glucose as energy without involving electron transport in mitochondria for ATP. Instead, they use Warburg-type metabolisms that may use glycolysis and/or the pentose phosphate pathway to generate metabolites and substrates required for growth and proliferation

2. Recent discoveries show cancer cells can switch to using mitochondria OXPHOS similar to healthy cells for energy production. This switch apparently, can be mediated by the presence of higher melatonin that occurs naturally at night in most animals.

3. So if you use melatonin during the daytime as part of an anti-cancer therapy, converting cancer cell energy metabolism back to a healthy phenotype using mitochondria oxidative phosphorylation, you may just retire the cancer population from employment.