1/9. In England, #SARSCoV2 infection rates in school-aged kids & #COVID19 outbreaks have both ⬆️ in recent weeks (latest data 4 July) but that does not change the narrative on kids & their role in infection/transmission in school

Here’s why … 🧵

👉 assets.publishing.service.gov.uk/government/upl…
2/9. No one has claimed that kids don’t get infected or don’t transmit #SARSCoV2 to others. But the data suggest that lower risk with kids than adults. Eg. We don’t see two-thirds of staff/students infected in a single outbreak as we do in care homes 👉 thelancet.com/journals/eclin…
3/9. We & others have shown that #SARSCoV2 cases & outbreaks reflect community infection rates. Cases in kids generally follow adults *unless* adults are in lockdown & kids continue to go to school. This happened in Nov/Dec 2020 & Mar/Apr 2021. See👇👇

👉 journalofinfection.com/article/S0163-…
4/9. After the Jan 2021 lockdown, schools opened on 08 March for 3 weeks (black circle). Cases were highest in secondary school children when mass LFD testing was implemented before they were allowed back in school, but then declined & remained low (they also wore masks in class)
5/9. After the Easter holidays, too, infection rates remained low in all school-aged children for *6 weeks* since mid-April (blue circle), when most of the adults were still in national lockdown & despite the emergence of the Delta variant in England - outbreaks too were limited
6/9. From 17 May (week 20), we eased into step 3 of opening lockdown & cases ⬆️ rapidly in all ages, esp 20-29 & 10-19 year-olds. Only 1 of these groups was in school.

Opening lockdown likely increased contacts & transmission chains outside schools

👉 assets.publishing.service.gov.uk/government/upl…
7/9. Interestingly, infections by age are better seen in ONS Survey (community testing, random households). Infections in primary & secondary school-aged kids remained low & only started ⬆️ after cases started increasing in year 12 to age 24 (~mid-June) 👉ons.gov.uk/peoplepopulati…
8/9. School outbreaks have also increased, especially after 17 May (red circle), although important to remember there are ~24,000 schools & <300 outbreaks (1-2% of schools). Also, outbreaks are defined as 2+ cases but these cases don’t have to be linked or infected in school 👇
9/9. In conclusion, #SARSCoV2 cases/outbreaks in schools remained ⬇️ when adults were in lockdown. This changed when lockdown eased (17 May). Vaccines will help keep community infection ⬇️ but we need more evidence-based mitigations in schools not just 4 #SARSCoV2 but all viruses

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Shamez Ladhani

Shamez Ladhani Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @ShamezLadhani

10 Jul
1/5. Mental health of Adolescents in the Pandemic: Long-COVID19 or Long-Pandemic Syndrome? (pre-print, thanks @MaryKRe)

Here’s another case-control study on long covid that measured #SARSCoV2 antibodies in teenagers

Here’s what they found … 🧵

👉 medrxiv.org/content/10.110…
2/5. 1560 kids (median age 15y):
- 188 (12%) seropositive (exposed to #SARSCoV2)
- 1365 (88%) seronegative (never exposed)

If you think this sample size is small, try bleeding 1500 teens!

They were asked the same questions ➡️ responses were near-identical in cases & controls
3/5. The authors did a subgroup analysis & found near-identical responses in teenagers who knew their #SARSCoV2 infection status vs those who didn’t

Yes, small samples size, but not even a signal of any difference in mental health status (see table👇)

👉 medrxiv.org/content/10.110…
Read 5 tweets
9 Jul
1/4 Childhood #COVID19 deaths. This preprint by @RCPCHtweets & @PHE_uk provides critical new information about #SARSCoV2 and kids which we didn’t have until now. Here’s why the small numbers in this paper matter 🧵

👉 researchsquare.com/article/rs-689…
2/4 Death is the most objective outcome & can be accurately measured in countries like England. The results show ~3,000 of 12 million kids died in 1 year & only 61 with #SARSCoV2. Detailed medical record analysis showed only 25 (42%) died *of* #COVID19

👉 researchsquare.com/article/rs-689…
3/4. Of the 25 kids who died of #COVID19, 19/25 (76%) had underlying conditions & of these 15/19 (60%) had a life-limiting condition & mostly with 2 or more medical conditions, esp. severe neurological conditions

👉 25 fatalities = 2 per million kids

👉researchsquare.com/article/rs-689…
Read 4 tweets
9 Jul
1/5 Both Pfizer & AZ vaccines are highly protective against severe #COVID19, especially after 2 doses.

Here’s why it’s better to stick to the same vaccine brand for both #COVID19 vaccine doses even after severe reaction following the 1st dose 🧵

👉 papers.ssrn.com/sol3/papers.cf…
2/5 Compared to 2 doses of the same vaccine brand, mixing Pfizer/AZ vaccines was associated with higher rates of severe reactions & requiring medical attention after the 2nd dose: esp. in younger adults, in women & in those with previous #COVID19 🧵

👉papers.ssrn.com/sol3/papers.cf…
3/5 Adults who had a severe reaction after their 1st dose of #COVID19 were more likely to have a severe reaction after 2nd dose, whichever vaccine they received, but risk of severe reactions increased if 2 different vaccine (AZ/Pfizer) brands given 🧵

👉 papers.ssrn.com/sol3/papers.cf…
Read 5 tweets
21 Jun
1/ News outlets & people on social media have been misinterpreting data on exposures prior to diagnosis as places where people caught #SARSCoV2 (provided in the @PHE_uk Weekly Reports)

Here’s why .…

👉 news.sky.com/story/covid-19… Image
2/. UK has been in lockdown since Nov. In Mar 2021, only schools reopened ➡️ 9 million children & education staff were out in the community. The figure below shows that a person was attending school prior to testing +ve for #SARSCoV2 - not that they caught #SARSCoV2 in school Image
3/ But as we eased into step 3 of opening lockdown, people were more likely to have visited other venues prior to testing +ve for #SARSCoV2

Here’s the same graph for the latest week reported. Eating out & “other” are now more frequent because restaurants & shops are open 👇 Image
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!

:(