1/n

Interesting take, because I'm sick of people being triggered by arithmetic, cost-benefit analysis, and conflating CFR/IFR.

Facts:

1) ~330 Pediatric deaths over 17 months with a +SCoV2 test through 7/14/21

2) We've had 27M Pediatric infections through 4/14/21 https://www.cdc.gov/nchs/nvss/vsrr/covid_weekly/index.htm#Sehttps://www.cdc.gov/coronavirus/2019-ncov/cases-updates/burd
2/n

Facts (cont):

3) 65 Pediatric C19 deaths were +SCoV2 with pneumonia. An additional 37 were from MIS-C.

4) ~40% of Pediatric C19 deaths are not due to C19
(35% in US review & 59% in UK review)

5) Makes sense as ~30-40% of Influenza is asymptomatic
ncbi.nlm.nih.gov/pmc/articles/P… https://www.cdc.gov/nchs/nvss/vsrr/covid_weekly/index.htm#Sehttps://www.cdc.gov/mis/cases/index.htmlhttps://www.cdc.gov/mmwr/volumes/70/wr/mm7014e2.htm?s_cid=mmhttps://www.researchsquare.com/article/rs-689684/v1
3/n

In the linked thread, @jeremyfaust estimates the Pediatric C19 fatality rate to be 1:10,000.

The upper bound is (330/27m)*0.6 => ~1:140,000

The estimate overshoots by at least 15x.

But that's still not the issue!

It's about value based decision making and risk analysis.
4/n

Let's leave alone that no more than a handful, and possibly 0, of these Pediatric deaths were in kids with a severe underlying condition.

There is a collective value of open schools, social interaction, mental health, and all of the economic and developmental benefits.
5/n

Spreading unwarranted fear about C19 threat to children compromises these benefits.

How high is "too high" to forgo these benefits? How high is high enough to vaccinate your healthy child?

As with adults, the conversation is risk based & personal.
The original tweet that I forgot to quote that inspired this short thread:

without a severe underlying condition *
And thank you @angrybklynmom for pointing out that the CDC estimate for Pediatric C19 admissions is off a model and is ~10x higher than actual HHS data (~30k).
*Correction to 4/n*

Let's leave alone that no more than a handful, and possibly 0, of these Pediatric deaths were in kids *without a severe* underlying condition.



Sorry 🙃

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More from @contrarian4data

1 Jul
1/

This is a numerical & narrative thread looking at the relationship between NPI (mandate) stringency and state level COVID outcomes in the USA.

Contents:
1) discuss motivation
2) present methods and sources
3) present results and implications
2

Motivation:

NPIs are disruptive. Nowhere in life do we entertain harm unless there is potential benefit. We are 16 months into this and have completed a full "epidemic cycle". We are in a period of COVID-19 quiescence nationally.

It's a good time to examine the results.
3/

So why examine the USA in isolation?

1) We have a heterogenous response (Oxford Stringency Avg 41.6 SDEV 9.2)

2) We have diverse demographics in key variables

3) '57, '68, 2009 Influenza pandemic outcomes suggest wide inter-country variation and 2+ years to "mature"
Read 30 tweets
16 Jun
1/n

I will be discussing this paper (along with a recent contribution) in an upcoming thread, but it highlights the importance of system level thinking over analyzing an intervention in isolation:

ncbi.nlm.nih.gov/pmc/articles/P…
2/n

"In Hong Kong and Bangkok during 2008–2011, large randomized controlled trials were conducted to investigate the efficacy of surgical face masks and enhanced hand hygiene in reducing transmission of influenza in households."
3/n

"[Influenza A is believed to spread via contact, large droplets and aerosols, but the relative importance of each of these modes of transmission is unclear. Volunteer studies suggest that infections via aerosol transmission may have a higher risk of febrile illness.]"
Read 17 tweets
24 May
This is a thread discussing Pediatric COVID-19 vaccination.

Contents:

1) Detailed review of Vaccine Adverse Events Reporting System (VAERS) for the 16yo-17yo age group
wonder.cdc.gov/vaers.html

2) Examine Pediatric mortality estimates & compare to adverse event rate

1/n
Contents (cont):

3) Review the # of patients required to assess efficacy & safety in the <18yo population

4) Review "# needed to treat" (NNT) & "# needed to harm" (NNH)

5) Extend discussion to "# needed to vaccinate" (NNV) & possible limitations of this concept

2/n
I downloaded the VAERS data for 6-17yo (so effectively just 16yo and 17yo) validated through 5/19/2021. I restricted analysis only "serious" events (returned 124 results).

wonder.cdc.gov/vaers.html

3/n
Read 27 tweets
15 May
The quoted thread, applies to all aspects of COVID policy.

One can’t discuss the limitations of archaic compartmental models, subtleties of inferential statistics, & computational modeling under uncertainty to incurious, social-credit seeking politicized acolytes.
People do not realize how numerically naive the medical establishment, & life science in general, is & has always been.

Add politics to the mix, & it becomes a potent mix of tribalism & misinformed morality.

I went silent when my current family got drawn in w/ repeated doxxing.
Some public Twatter profiles who bravely do not tow the line:
@VPrasadMDMPH, @MonicaGandhi9, @TracyBethHoeg,
@sdbaral,
@MartinKulldorff

They can only say so much w/ careers & professional standing on the line.

Few know that 2 have a more wrong than right politicized boss.
Read 5 tweets

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