ICYMI: The @cdc's Dr. Jay Butler talked to the @IDSAInfo this week on the Delta variant and vaccines. vimeo.com/574457791

2/3 of all adults have gotten 1 dose of vaccine, including 90% over age 65 have gotten one dose, 80% of those over 65 are fully vaccinted.
@cdc's Dr. Jay Butler says no evidence of waning immunity from covid vaccines.
@AndrewPaviaMD Hospitalizations in Utah have doubled. Case positivity rates have tripled. ICU's are now operating at over 100% capacity. Haven't yet had to create emergency ICUs, which is normally full in summer due to trauma.
@AndrewPaviaMD It's harder to treat these late covid surges b/c nurses are so burned out. "A lot of people are at the end of their rope."
@AndrewPaviaMD Rates of hospitalization are highest in rural areas, where vaccination rates are low. 50% of all people in Utah have gotten first dose, including young people not eligible for vaccine.
In Utah, 92% of sequenced variant viruses were delta in the past week. Delta is more "fit" than other variants. It's spreading among unvaccinated. vimeo.com/574457791
@AndrewPaviaMD: What's driving spread of the virus is people wanting it to be over and acting like it's over, although it's not.
Dr. Jay Butler of @CDCgov: Over 99% of all covid cases are occurring in unvaccinated people.
Jay Butler: Biggest concern is among those who are most medically vulnerable to covid, or those who are immune-compromised.
@AndrewPaviaMD: Giving covid boosters too soon would waste vaccine that rest of the world desperately needs, but giving them too late risks allowing people to become sick. vimeo.com/574457791
Jay Butler of @CDCgov: It's still unclear if coronavirus falls into a seasonal pattern.
Jay Butler of @CDCgov: Hospitalizations have increased in past week. Not yet a major spike in deaths, says Andrew Pavia, probably because so many older people are vaccinated.
@AndrewPaviaMD: Is Delta causing more severe disease in younger people? Anecdotally, there could be more virulence, but we don't know yet.
Jay Butler: We're getting better at treating covid, so that may be keeping mortality rates lower during these latest surges.
@AndrewPaviaMD: Although mortality rates are relatively low, death is not the only thing to worry about. "Surviving after 2 weeks in the ICU is an incredibly traumatic, life-changing experience, so I don't want people to be too reassured by that."
Jay Butler of @CDCgov says vaccine protects against severe illness and reduces infectiousness. Breakthrough cases rare, they are also milder, and people shed less virus.
@AndrewPaviaMD: If it's your child in the ICU, or your child who ends up with long covid, that doesn't seem like mild disease. CDC is studying whether MIS-C is more common with Delta variant. vimeo.com/574457791

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More from @LizSzabo

16 Jul
I don't want to criticize nurses, b/c they work incredibly hard. But when my dad was hospitalized, it wasn't helpful for them to tell me every day that he was "looking better today." He was elderly, w/ dementia & other comorbidities. He was never going to get better. 1/
His nursing home sent him to the hospital, where he was in the ICU on bipap. (He was DNR and we said no ventilators.) After a few days, his breathing improved, he switched to a nasal cannula for oxygen. That doesn't mean he was 'better." 2/ #hpm
Do nurses feel pressure to keep families' hopes up?I've written about hospice & the end of life for years, but that sort of false hope could keep other families from accepting reality. #hpm /3
Read 23 tweets
17 Mar
@theNAMedicine @PublicHealth LIVE: Speakers at @theNAMedicine webinar on variants include some heavy hitters of science: @CarlosdelRio7, @angie_rasmussen, Dr. David Ho of @Columbia & @MonicaGandhi9 .
@theNAMedicine @PublicHealth @CarlosdelRio7 @angie_rasmussen @Columbia @MonicaGandhi9 Live: @angie_rasmussen: Viruses have smaller genomes but mutate much more than complex cells.
@theNAMedicine @PublicHealth @CarlosdelRio7 @angie_rasmussen @Columbia @MonicaGandhi9 Live: @angie_rasmussen: Mutations are scattered randomly through coronavirus genome, although the ones of most concern relate to the spike protein, which helps virus enter our cells.
Read 26 tweets
16 Mar
Live from International Antiviral Society–USA (IAS–USA)

One monoclonal antibody is good, two is better.
Live from International Antiviral Society–USA (IAS–USA)

Dr. Jonathan Li: Mutations occur between the areas where antibodies bind to virus and the spike protein.
Live from International Antiviral Society–USA (IAS–USA) @DrJLi is talking about variants. Vaccines appears to protect against the B.1.1.7 variant (originally found in the UK) as well as the original virus.
Read 15 tweets
15 Mar
JAMA LIVE. @CarlosdelRio7 notes there will be PTSD caused by the pandemic.
JAMA LIVE: When asked which vaccine she recommends, @PreetiNMalani said to get the first vaccine you can. "They all work beautifully on severe disease."
JAMA LIVE: @CarlosdelRio7 and @PreetiNMalani said the vaccines reduce infectivity, likely protect against infection. "Even if you get infected, you may not make enough virus to be infectious."
Read 4 tweets
5 Mar
LIVE @NC4HR: Dr. Paul G. Auwaerter of @JohnsHopkinsDOM notes that people infected with B.1.1.7 variant are infectious longer -- eight days instead of five days.
LIVE @NC4HR: Dr. Paul G. Auwaerter of @JohnsHopkinsDOM notes effectiveness of mRNA vaccines in Israel as good as in clinical trials.
Good protection in people over 70, who normally don't do as well with vaccines. Image
LIVE @NC4HR: Dr. Paul G. Auwaerter notes Houston has four variants circulating in the city.
Read 18 tweets
3 Mar
This slide includes data that could be used to argue both for/against giving everyone one dose before giving people a second.
Here's another slide contrasting the arguments for/against giving everyone one dose before anyone gets the second. One major point: The one-dose strategy would violate the FDA's emergency use authorization.
CDC advisory panel yesterday also debated whether people who've had covid need 2 shots or 1. Once again, giving only one shot would violate the FDA's emergency authorization.
Read 16 tweets

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