2/3 of all adults have gotten 1 dose of vaccine, including 90% over age 65 have gotten one dose, 80% of those over 65 are fully vaccinted.
@cdc's Dr. Jay Butler says no evidence of waning immunity from covid vaccines.
@AndrewPaviaMD Hospitalizations in Utah have doubled. Case positivity rates have tripled. ICU's are now operating at over 100% capacity. Haven't yet had to create emergency ICUs, which is normally full in summer due to trauma.
@AndrewPaviaMD It's harder to treat these late covid surges b/c nurses are so burned out. "A lot of people are at the end of their rope."
@AndrewPaviaMD Rates of hospitalization are highest in rural areas, where vaccination rates are low. 50% of all people in Utah have gotten first dose, including young people not eligible for vaccine.
In Utah, 92% of sequenced variant viruses were delta in the past week. Delta is more "fit" than other variants. It's spreading among unvaccinated. vimeo.com/574457791
@AndrewPaviaMD: What's driving spread of the virus is people wanting it to be over and acting like it's over, although it's not.
Dr. Jay Butler of @CDCgov: Over 99% of all covid cases are occurring in unvaccinated people.
Jay Butler: Biggest concern is among those who are most medically vulnerable to covid, or those who are immune-compromised.
@AndrewPaviaMD: Giving covid boosters too soon would waste vaccine that rest of the world desperately needs, but giving them too late risks allowing people to become sick. vimeo.com/574457791
Jay Butler of @CDCgov: It's still unclear if coronavirus falls into a seasonal pattern.
Jay Butler of @CDCgov: Hospitalizations have increased in past week. Not yet a major spike in deaths, says Andrew Pavia, probably because so many older people are vaccinated.
@AndrewPaviaMD: Is Delta causing more severe disease in younger people? Anecdotally, there could be more virulence, but we don't know yet.
Jay Butler: We're getting better at treating covid, so that may be keeping mortality rates lower during these latest surges.
@AndrewPaviaMD: Although mortality rates are relatively low, death is not the only thing to worry about. "Surviving after 2 weeks in the ICU is an incredibly traumatic, life-changing experience, so I don't want people to be too reassured by that."
Jay Butler of @CDCgov says vaccine protects against severe illness and reduces infectiousness. Breakthrough cases rare, they are also milder, and people shed less virus.
@AndrewPaviaMD: If it's your child in the ICU, or your child who ends up with long covid, that doesn't seem like mild disease. CDC is studying whether MIS-C is more common with Delta variant. vimeo.com/574457791
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I don't want to criticize nurses, b/c they work incredibly hard. But when my dad was hospitalized, it wasn't helpful for them to tell me every day that he was "looking better today." He was elderly, w/ dementia & other comorbidities. He was never going to get better. 1/
His nursing home sent him to the hospital, where he was in the ICU on bipap. (He was DNR and we said no ventilators.) After a few days, his breathing improved, he switched to a nasal cannula for oxygen. That doesn't mean he was 'better." 2/ #hpm
Do nurses feel pressure to keep families' hopes up?I've written about hospice & the end of life for years, but that sort of false hope could keep other families from accepting reality. #hpm /3
Live from International Antiviral Society–USA (IAS–USA)
One monoclonal antibody is good, two is better.
Live from International Antiviral Society–USA (IAS–USA)
Dr. Jonathan Li: Mutations occur between the areas where antibodies bind to virus and the spike protein.
Live from International Antiviral Society–USA (IAS–USA) @DrJLi is talking about variants. Vaccines appears to protect against the B.1.1.7 variant (originally found in the UK) as well as the original virus.
JAMA LIVE. @CarlosdelRio7 notes there will be PTSD caused by the pandemic.
JAMA LIVE: When asked which vaccine she recommends, @PreetiNMalani said to get the first vaccine you can. "They all work beautifully on severe disease."
JAMA LIVE: @CarlosdelRio7 and @PreetiNMalani said the vaccines reduce infectivity, likely protect against infection. "Even if you get infected, you may not make enough virus to be infectious."
LIVE @NC4HR: Dr. Paul G. Auwaerter of @JohnsHopkinsDOM notes that people infected with B.1.1.7 variant are infectious longer -- eight days instead of five days.
LIVE @NC4HR: Dr. Paul G. Auwaerter of @JohnsHopkinsDOM notes effectiveness of mRNA vaccines in Israel as good as in clinical trials.
Good protection in people over 70, who normally don't do as well with vaccines.
LIVE @NC4HR: Dr. Paul G. Auwaerter notes Houston has four variants circulating in the city.
This slide includes data that could be used to argue both for/against giving everyone one dose before giving people a second.
Here's another slide contrasting the arguments for/against giving everyone one dose before anyone gets the second. One major point: The one-dose strategy would violate the FDA's emergency use authorization.
CDC advisory panel yesterday also debated whether people who've had covid need 2 shots or 1. Once again, giving only one shot would violate the FDA's emergency authorization.