[Thread] Who is the first known patient?
There is a lot of confusion, so let's review all possible patients according published onset dates [of symptoms] up to 15-Dec-19.
Notation
Patients are anonymized, so they are identified as <AgeSex> (e.g. 49F is a 49-year-old female). In case there are many patients with same age & sex, suffixes are used (e.g. 65M1, 65M2, ...).
U = Unknown.
Problem: people can have birthday during illness
XX Su (61F), XX Wang (62M) & XX X (UU) onset 14, 21 & c. 30-Nov-19.
Info unnoticingly leaked in Health Times and uncovered by DRASTIC and @ianbirrell
A person (55U) onset 17-Nov-19, with a total of four men and five women aged between 39 and 79 in Nov-19. Nothing else has been heard of these cases scmp.com/news/china/soc…
Connor Reed (25M) onset 25-Nov-19.
Had a diary with many details. Confirmation of having had the virus on 15-Jan-2020.
Died in Oct-20 and the investigation has not concluded yet.
Btw, where is his diary? (useful to know where he was the week before onset) dailymail.co.uk/news/article-8…
XX Zhao (85F) [not so clear] onset 26-Nov-19.
She had a bad condition so she was admitted to hospital. Official death #18 on 21-Jan-20 according to Red Dawn (FOIA ht @CharlesRixey).
Probably first known death due to nosocomial COVID19 infection. RIP
XX X (62M & possibly not Wang-62M; WIV01) onset initially considered 01-Dec-19 by Huang et al. (2020) or 12-Dec-19 by Zhou et al. (2020), but now considered 26-Dec-19.
(more details in embedded thread)
XX Chen (41M1, S01, Wuchang accountant) onset now officially 08-Dec-19 but real onset 16-Dec-19.
Lineage B. Convenient 1st case to divert attention of WHO experts.
Probably a dead end with unknown connection with wet market cluster (e.g. public transport)
Guixian Wei (57F1, seafood merchant in wet market) onset 10-Dec-19. Went to small private clinic, Union & Tongji.
(This WSJ article is a must read; AFAIK, it includes the first graphical COVID proof) wsj.com/articles/how-i…
XX Yin (48F) onset 10-Dec-19. Tongji & Jinyintan.
I guess the real onset was later (admission was on 27-Dec-19).
Official death #7 on 20-Jan-20. RIP
Probably same 48F as in Cluster 3 of Li et al. (2020) with onset 15-Dec-19; exposure to 49M (see next)
XX X (49M, vendor wet market) onset 12-Dec-19. Jinyintan.
Cluster 3 index case of Li et al. (2020)
Note: they used reversed notation in Fig. 3 (i.e. 49M = M49) ncbi.nlm.nih.gov/pmc/articles/P…
XX X (44M, transportation staff wet market, apparently different from S03 (WH01) in China-WHO report, also a 44M) onset c. 12-Dec-19. Union.
Not official case, but very clear. Probably first known death. RIP
AFAIK, nobody is studying this key case! Shame! ncbi.nlm.nih.gov/pmc/articles/P…
XX X (65M1, S02) onset 15-Dec-19 (13-Dec-19 according China-WHO report). Central, Tongji, Jinyintan.
First known to be sequenced (26-Dec-19), but not first published.
Caixin reported he died, so he could be XX Song (also a 65M) who died on 24-Jan-20, official death #35 (RIP).
XX X (UU) onset 15-Dec-19.
First case outside Wuhan, in Yichang. We do not know anything. Shame!
[Thread] Necessary corrections to the China-WHO report.
What they will probably fix and what they will not.
TLDR: circular swap of 3 IPCAMS genomes + tampered onset of Wuchang accountant; First patients and first cluster; Some falsehoods in articles washingtonpost.com/world/asia_pac…
As we said, the problems were with S01, S05 & S11. Absolutely chaotic, but with a little table it is all more clear. Part of the problem is inherited from Ren et al. (2020) who followed different orders in the text and in the genomes for the patients.
"It shows how an authoritarian government can successfully shape the narrative of a disease outbreak and how it can take years — and, perhaps, regime change — to get to the truth"
"“You can concoct a completely crazy story and make it plausible by the way you design it,” Dr. Meselson said, explaining why the Soviets had succeeded in dispelling suspicions about a lab leak"
“Those who don’t want to accept the truth will always find ways not to accept it.”
[Thread] Bat tissue collection and cell lines from the 3rd trip to Tongguan (TG) mine in Mojiang in Apr-2013
The 3rd trip is still my first guess for being the trip of live isolate WIV15 (and backbone). I guess it is more probable to isolate a virus from tissue itself... What do the experts say?
Jan 7, 2021, AVC Panel Discussion Origins of SARS-CoV-2 (from @KatherineEban's article)
“the incredible difficulty of isolating live virus from bat samples, which are usually fecal samples, and that this is extremely unreliable and usually not successful” downloads.vanityfair.com/lab-leak-theor…
"The mounting evidence that the COVID-19 coronavirus escaped from the WIV, rather than spontaneously emerging from nature, had become the hottest topic in journalism and potentially the most consequential science story in a generation" commentarymagazine.com/articles/james…
"The COVID-19 pandemic revealed a profound corruption at the heart of our expert class. The impact of that revelation will reverberate for years to come"
"“The DRASTIC people are doing better research than the U.S. government,” a State Department investigator told Vanity Fair"
The previous mainstream narrative of "anything outside of a zoonosis is a conspiracy theory" was built upon two letters (not articles), among most cited papers of the year. Even Dr. Shi used them. They are both sinking now.
1/ The proximal origin of SARS-CoV-2
The corresponding author is self-debunking, and a co-author was de-facto retracting
2/ Lancet's letter (or Daszak's letter)
It did not fare any better. It was proved orchestrated by @PeterDaszak and, AFAIK, at least three co-authors de-facto retracted publicly declaring that the question of the origin was open
They finally concede after more than a year: "Here, we report the identification of a novel lineage of SARSr-CoVs, including RaTG15 and seven other viruses, from bats at the same location where we found RaTG13 in 2015"
No mention to the miners or the mine. Just this: "in Tongguan town, Mojiang county, Yunnan province in China in 2015, the same location where we found bat
RaTG13 in 2013"