Diana Berrent Güthe Profile picture
Jul 22, 2021 18 tweets 10 min read Read on X
Let's talk about breakthrough symptomatic infections in fully vaxxed adults...

Today @SurvivorCorps will meet with the @CDCgov to present our data and ask for changes in policy to reflect real world evidence.

@CDCgov is only tracking hospitalized cases so we did it instead.
/
We ran a poll of our 170K member group and had 1949 fully vaxxed adults participate.

Our Key Takeaways:

-Vaccines Work (but not all the time)

-Of 1949 fully vaxxed adults there were 44 breakthrough symptomatic cases (we couldn't measure asymptomatics for obvious reasons)
2/
-Vaccines will likely keep you from acute symptomatic Covid needing hospitalization

-*HOWEVER* 55% of breakthrough symptomatic cases led to Long Covid (this is staggering)

-(Narrator Voice: If I had J&J I would want a booster)
3/
Tl/dr: Breakthrough symptomatic cases of Covid in fully vaccinated adults lead to #LongCovid. Full Stop.
#LongTermCovid
4/
Based on this data the CDC should revise its guidance:
-Vaxxed ppl should remain masked indoors
-Vaxxed ppl should get tested when symptomatic
-CDC should mandate reporting of All breakthrough cases
-CDC should mandate reporting of ALL vaccine injuries (VAERS is a bust)
5/
We cannot track what we aren’t counting.

Have we not learned that simple lesson from a mere year and a half ago?

Low testing doesn’t mean low numbers; it means bad science.
6/
We are also creating a new cohort of untested individuals who will struggle with diagnoses of Long-Term Covid, a devastating multi-organ condition that can ravage the body of the youngest and healthiest among us.
This is also the backbone of our economy. #LongCovid
7/
Our data is somewhat skewed b/c it was done within Survivor Corps. While this is not data you are going to take to the bank, it offers a tremendously compelling clue that our policies are not in line with what’s really happening on the ground.

And it's the only data we have.
8/
And, remember, even a really small percentage of a really big number is still a really big number.
9/
This is Citizen Science 2.0... Citizen Scientist Collaboration.

We are honored to collaborate with @DaisySMassey and @hmkyale @Yale @YaleMed on this and other projects.

Stay tuned for our imminent publication on MedRxiv
10/
Full breakdown by vaccine below:

Total – Of 1949 fully vaxxed adults there were
- 44 symptomatic breakthrough cases (2.3%)
- 24 of which led to Long Covid (55%)

3 Hospitalizations (only one of which led to Long Covid).
(These would be only 3 counted under current rules)
11/
Pfizer:
Of 1024 adults fully vaxxed with Pfizer there were
- 19 breakthrough symptomatic cases (1.8%);
- 12 of which led to LC (63%);
- Zero hospitalizations
12/
Moderna:
Of 775 adults fully vaxxed with Moderna there were
- 17 breakthrough symptomatic cases (2.2%);
- 6 of which led to LC (35%)
- 1 hospitalization (no Long Covid)
13/
J&J:
Of 150 adults fully vaxxed with J&J there were
- 8 breakthrough symptomatic cases (5.3%);
- 6 of which led to Long Covid (75%);
- 2 hospitalizations (one of whom developed Long Covid)
14/
And yes I tagged the wrong Survivor Corps… 🤷‍♀️ @Survivor_Corps
Let me clarify for those in the last row… this is data based off of a biased sample. No one is suggesting that 55% of breakthrough symptomatic infections lead to Long Covid in the general population.

The fact that some cases do, though, means we should be tracking it.
@hmkyale
Our paper on Breakthrough Symptomatic cases leading to #LongCovid has been published. With @DaisySMassey and @hmkyale

@YaleMed @Survivor_Corps

THIS is Citizen Scientist Collaboration at work.

medrxiv.org/content/10.110#medtwitter

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More from @dianaberrent

Jan 27
In case you were wondering about COVID reactivating latent viruses....

I got bloodwork done yesterday after having Covid earlier this month (and developing cold / canker sores in my mouth).

I had never had them before. Image
"HHV (Herpes) reactivation was considered a positive polymerase chain reaction result taken at the time of COVID-19 infection."
pubmed.ncbi.nlm.nih.gov/36880642/
Maybe it's time to lower the age minimum (currently 50) for the Shingles vaccine for those of us old enough to have had the Chicken Pox... 🤔

Shingles is the reactivation of Chicken Pox.

Multiple Sclerosis is the reactivation of EBV (Mono).

See the pattern?
Read 7 tweets
Jan 13
What if I told you there was a simple OTC that you could take during acute COVID that could help prevent a cytokine storm?

What if I told you there weren't more studies because the government won't fund the research because of... optics?

That thing is nicotine.

True story.
No one is suggesting taking up 🚬!!!

One week on a nicotine patch.

Early papers from 2020 make the connection.

Since then? 🦗🦗🦗

I wonder why 🤔
Read 8 tweets
Jan 12
Welcome to Covid 101 (Season 2024)

@NickGuthe and I both got Covid.

I took Paxlovid for 10 days. He couldn't stand the taste and stopped at 5.

He tested neg for 5 days and is now sicker than before, testing strongly positive.

This is NOT a rebound. There is no such thing.

1/ Image
This is the natural viral cycle of Covid that has been constant from the beginning:

Days 5-8 were *always* the danger zone.

You either started to recover or entered the cytokine storm that put people in the hospital and on vents.

2/
A so-called "rebound" is likely an indication that you had a high viral load to begin with and would have ended up much sicker without Paxlovid.

3/
Read 8 tweets
Mar 13, 2023
In February 2021 Congress gave the @NIH $1.15 Billion to study #LongCovid.

They decided to start with an observational cohort.

Recruitment started October 2021.

Recruitment status as of TODAY:

13,365 out of 17,000 adults
2917 out of 6000 peds

Where did the money go????

1/
In April 2021 @NIH put out a call to scientists to apply for trials (how things should work).

No applications were accepted and clinical trials were put on hold.

As of TODAY:

- no trial protocol has been completed
- no trial sites have been chosen
- no trials have started

2/
The piece de resistance of RECOVER was to be (sadly not the clinical trials) a registry*

The registry was supposed to start recruiting Dec. 2022.

As of TODAY it is on hold (pulled?)

* @Survivor_Corps @ColumbiaMed @ChanZuckerberg @Sagebio started this in Summer 2020 fwiw

3/
Read 10 tweets
Dec 5, 2022
👉 Looking for some advice...

A 🧵...

From the beginning of the Pandemic @Survivor_Corps has led the way.

A few examples:

- Kicked off plasma movement in early 2020 (we saved hospitals and blood bankers a fortune b/c they never had to advertise. We did it for them)

1/
- Provided free and immediate access to Monoclonal Antibodies and other early Therapeutics through our portal GotCOVID.org (we did it way better and waaay faster than the US Government - they agreed)

2/
- Advised White House / CDC / HHS / NIH / Congress etc etc (all unpaid except for one HHS contract - Health Plus)

- Linked every major media outlet (and all the small ones too) with real people to tell their COVID stories (we basically act as unpaid bookers)

3/
Read 9 tweets
Nov 23, 2022
Let's revisit COVID testing.

Here's the story of my 14yo kid today... (his bff tested positive earlier today and they spent the weekend together)

1/
- 14yo presented with sore throat Monday. BFF tested positive = known exposure.

Tested negative on RAT (nose only)

2/
- Tested negative Tuesday on rapid antigen test [RAT] (administered via nose only)

3/
Read 7 tweets

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