1/ The Nobel laureate André Lwoff suggested part of the hypothesis in 1959, when he noted that the degree of virulence of viruses is often related to their level of thermal sensitivity
journals.asm.org/doi/pdf/10.112… …
journals.asm.org/doi/pdf/10.112… …
2/ In 1979, Richman and Murphy developed this further, discussing many examples of thermal sensitivity in natural and lab‐made viral strains, and noting that the near‐universal attenuation of ts strains made them good candidates for vaccines.
doi.org/10.1093/clinid…
doi.org/10.1093/clinid…
3/ The full hypothesis was proposed by Shaw Stewart and discussed at length in 2016, focusing on seasonality and the natural selection of strains with varying degrees of thermal sensitivity and pathogenicity
doi.org/10.1016/j.mehy…
doi.org/10.1016/j.mehy…
4/ The same hypothesis was put forward by Eccles in 2020, this time concentrating on the advantages of
thermal sensitivity to the virus
doi.org/10.1002/rmv.21…
thermal sensitivity to the virus
doi.org/10.1002/rmv.21…
6/ Video for the non-scientist
7/7 A lot of scientists seem to struggle with this idea - though @JuliaLBach8 and I think we are pretty much stating the obvious - well-understood by folk wisdom for generations !
My friend Brian (non-scientist) gets it
My friend Brian (non-scientist) gets it
• • •
Missing some Tweet in this thread? You can try to
force a refresh
