Now that the #alphafold hype has completely died down (ha!), I've written a new blog post on the AF2 method paper: moalquraishi.wordpress.com/2021/07/25/the…. This is a technical deep-dive into aspects of AF2 that I find most surprising/innovative and of relevance to broader biomolecular modeling.
My post is _not_ a high-level summary of how AF2 works. For that I suggest @c_outeiral's blog post blopig.com/blog/2021/07/a….
Should say that we will have in a couple of weeks a formal review paper out that is a high-level overview of AF2 and its implications.

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More from @MoAlQuraishi

30 Nov 20
CASP14 #s just came out and they’re astounding—DeepMind looks to have solved protein structure prediction. Median GDT_TS went from 68.5 (CASP13) to 92.4!!!! Cf. their 2nd best CASP13 struct scored 92.8 (out of 100). Median RMSD is 2.1Å. I think it's over predictioncenter.org/casp14/zscores…
These are for single domains-not whole proteins-and there are a few poor predictions. So corner cases remain but core problem appears solved: 88% of predictions are <4Å, 76% <3Å, 46% <2Å. Unlike last time where there was some competition, this time AF2 was best for 88/97 targets.
DeepMind's blogpost: deepmind.com/blog/article/a…
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