Pfizer research chief on quarterly earnings conf call just now: "We continue to believe it is likely that a third dose may be needed within six to 12 months of the full vaccination to maintain the highest level of protection." #covid19
Pfizer has contracts for 2.1B #covid19 vaccine doses in 2021, and plans to make 3B this year. CEO says on conf call just now co is in advanced discussions for many of the remaining doses and expects they'll all be allocated. Capacity for 2022 expected to be 4B doses.
Bernstein's Ronny Gal predicts an additional ~$10B in 2021 revenue for remaining #covid19 vaccine doses not yet contracted. Would mean $43.5B in total 2021 revenue from the Covid vaccine.
On need for #covid19 vaccine boosters, Pfizer CEO says waning in immunity is clearest first against mild disease, but can be seen against severe disease as well. "What used to be 100% in the first month, now it's coming to the low 90s, and in some cases to the 80s."
• • •
Missing some Tweet in this thread? You can try to
force a refresh
Pfizer plans to file for full approval of its #covid19 vaccine at the end of May, per its slide deck just posted for Q1 earnings. It now sees revenue from the vaccine this year of $26B. s21.q4cdn.com/317678438/file…
Pfizer plans to conduct study of pneumonia vaccine candidate w booster dose of #covid19 vaccine, w results expected in Q3 2021, in anticipation a potential booster of Covid vaccine will be authorized & recommended in US as early as fall/winter 2021: s21.q4cdn.com/317678438/file… (p13)
Pfizer plans to start phase 2/3 trial of oral antiviral for #covid19 in Q3, data in Q4, followed by EUA submission before year-end (presuming data are positive)
FDA says it concludes inspection of Emergent plant, issues 483 letter. Production of J&J vaccine remains stopped until issues are remediated. 483 letter here: fda.gov/media/147762/d…
FDA observations re Emergent plant:
1: Failure to conduct thorough investigations into unexplained discrepancies.
Specifically, cross-contamination of two viral vaccines. FDA: “there is no assurance that other batches have not been subject to cross-contamination.”
Note- FDA cites “cross-contamination of client [redacted] viral vaccine drug substance batch... with the virus from client [redacted].”
Emergent’s CEO April 1: “It wasn’t the case where an ingredient from one vaccine contaminated or impacted the other.”
-@aslavitt46: Nearly 1 in 5 adults and nearly half Americans 65+ have received first shot
.@aslavitt46: Biden Admin asking businesses to:
-require masking & social distancing to protect workers, customers
-reduce barriers to vaccination, provide incentives (paid time off, compensation)
-communicate w customers, educate public about benefits of masking & vaccination
.@aslavitt46 on business contribution:
🔹Ford and the Gap producing & donating millions of masks
🔹Pro sports & live events offered 100+ stadiums, venues for vaccination sites
🔹Retailers like Best Buy, Target, Dollar General gave 500K+ workers PTO or compensation to get vax
Moderna notes in earnings release this AM it's completed enrollment of its #covid19 vaccine study in kids ages 12-17 (study is called TeenCOVE); a phase 2 study in ages 6 months - 11 years (KidCOVE) will start "in the near-term" investors.modernatx.com/news-releases/…
Along w boosters of original vaccine & B.1.351-tailored vaccine, Moderna says it's developing a next-gen vaccine encoding for portions of the spike protein critical for neutralization (RBD & NTD). Shorter antigen & hoped to be fridge-stable. Plans to test as booster and primary.
Moderna details #covid19 vaccine supply deals:
US: 300M (option for 200M more)
EU: 310M (option for 150M in 2022)
Japan: 50M
Canada: 44M
Korea: 40M
UK: 17M
Switzerland: 13.5M
Colombia: 10M
Israel: 6M
Taiwan: 5M
Singapore: undisclosed
Qatar: undisclosed
White House #covid19 briefing now. @JeffZients says in March, govt will delivering millions of masks to food banks and community health centers around the country. In total, 25M masks to more than 1300 health centers and 60k food pantries nationwide. Free, American-made.
.@JeffZients: Masks will be well-fitting cloth masks available in children’s and adult sizes, and can be washed for reuse, all consistent with CDC guidance.
.@JeffZients on #covid19 vaccine allocation this week: 14.5M doses to states, 2.1M doses to federal retail pharmacy program. Notes pharmacy program “has performed well so far.”
In written testimony posted ahead of Congressional hearing tomorrow, Moderna president Stephen Hoge notes the company is in the process of 'onboarding' another fill-finish partner (along w Catalent) for its #covid19 vaccine in the US: docs.house.gov/meetings/IF/IF…
Written testimony also showing how mRNA vaccine supply is ramping up in US:
J&J updates on expected #covid19 vaccine supply in written congressional testimony for hearing tomorrow: 20M+ doses to US by end of March, assuming necessary regulatory approvals re: manufacturing (100M total by end of June; 1-dose vaccine): docs.house.gov/meetings/IF/IF…