In written testimony posted ahead of Congressional hearing tomorrow, Moderna president Stephen Hoge notes the company is in the process of 'onboarding' another fill-finish partner (along w Catalent) for its #covid19 vaccine in the US:…
Written testimony also showing how mRNA vaccine supply is ramping up in US:

Moderna says it aims to double output to 40M+ doses per month by April:…

Pfizer says it's more than doubling to 13M+ doses per week by mid-March:…
J&J updates on expected #covid19 vaccine supply in written congressional testimony for hearing tomorrow: 20M+ doses to US by end of March, assuming necessary regulatory approvals re: manufacturing (100M total by end of June; 1-dose vaccine):…
AZ notes in congressional testimony that recruitment for its US ph3 #covid19 vaccine trial is now complete. Bc infection rate has been high, "we are hopeful that the readout of
the data will be available in the coming weeks."…
AZ notes in testimony its US phase 3 #covid19 vaccine trial uses a 4-week interval for the doses, which "may not maximize efficacy" compared to a longer dosing schedule. (…)
AZ says in testimony it's benefited from use of Defense Production Act: "Since the Defense Production Act Title I priority rating was put in place, our suppliers have not communicated any significant delays of materials or equipment." Doesn't specify dose # if/when granted EUA
AZ says it could take 8-9 months to update its #covid19 vaccine to new variants, which it's already working on for P1 (Brazil) and B.1.351 (South Africa): "it is likely the process from start to finished product would take 8 to 9 months to complete."
Novavax says in testimony it plans to begin clinical testing of new #covid19 vaccine candidates against variants in the first half of this year. With ph3 trial fully enrolled today, says it plans to complete FDA submission in Q2; supply: 110M doses by Q3:…

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More from @megtirrell

5 Feb
WH #Covid19 briefing:
@aslavitt46 says US govt using Defense Production Act to:
-increase supply of vaccinations
-scale tests
-reduce dependence on foreign supplies
.@aslavitt46: 6 more cos will surge manufacturing of at-home test kits, with goal of by summer millions of Americans being able to access at-home tests
.@aslavitt says Defense Sec ordered first contingent of 1000+ active duty military personnel to support state vaccination sites. Part of group will start to arrive in CA within next 10 days to begin operations around Feb 15, with additional vaccination missions soon to follow
Read 8 tweets
2 Feb
New Oxford/AstraZeneca #covid19 vaccine pre-print. Pooled analysis of their phase 3 efficacy trials in UK & Brazil + phase 1/2 clinical trials in UK and South Africa.

17,177 volunteers overall
UK: 8,948
Brazil: 6,753
South Africa: 1,476

332 infections >14 days post dose 2
Overall vaccine efficacy for Oxford/AZ #covid19 vaccine >14 days after 2nd dose = 66.7%

Complete protection against hospitalization "after 21 day exclusion period." (15 hospitalizations in control group, none in vaccine group.)
Oxford/AZ report #covid19 vaccine efficacy of 76% with just a single shot, between Days 22 and 90.

Say antibody levels are maintained with minimal waning 3 months out.
Read 4 tweets
2 Feb
WH #Covid19 briefing now. @JeffZients says starting Feb 11, federal govt will deliver vaccines directly to select pharmacies across the country. Will provide more sites for people to get vaccinated in their communities and important component for vaccine equity.
.@JeffZients: #covid19 vaccine pharmacy program will include 6500 stores nationwide in the early phase before expanding. Warns though that many initially will have only limited supply.
Eventually up to 40k pharmacies nationwide could provide #covid19 vaccines, @JeffZients says. Notes overall effort also includes mass vaccination sites, mobile clinics, community health centers & other providers.
Read 6 tweets
2 Feb
Pfizer research chief just detailed on earnings call what sounds like an interesting divergence in #covid19 vaccine strategy re: variants compared with Moderna. Says Pfizer testing boosts of original vaccine at 6 and 12 months out. (1)
Pfizer's Dolsten notes mRNA vaccines generate high antibody levels, and expects even against B.1.351 & P1 variants that those levels mean the vaccines will be "much more resistant to breakthroughs."

Expects a booster w original vaccine may get antibody levels high enough. (2)
In contrast, Moderna has said it's already working on a new #covid19 vaccine construct, mRNA-1273.351, in case it's needed:…

Moderna also testing booster w original (3)
Read 4 tweets
1 Feb
.@aslavitt46 announces Dept of Defense & HHS have awarded $230m to Ellume, maker of first OTC at-home #covid19 test.

Ellume to ship 100k test kits to US per month from Feb - July.

New funding will scale manufacturing capacity to 19m test kits/mo by end of year. 8.5m to US govt.
.@aslavitt46 on #covid19 vaccine supply: We believe some health-care providers are regularly holding back doses that are intended as 1st doses & instead keeping as 2nd dose reserves. We understand why, but it does not need to happen and should not happen.
.@aslavitt46: With 3-week window of visibility into vaccine supply, states & health-care providers should have predictability & not feel they need to reserve 2nd doses to ensure they'll have them.
Read 4 tweets
27 Jan
Dr Fauci slide on #covid19 vaccines and when results are expected, from first White House Covid-19 response briefing: Image
Dr Fauci slide on coronavirus variants of concern: Image
.@ASlavitt now presenting at WH #COVID19 response briefing. “It’s been a busy 7 days.” Image
Read 5 tweets

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