Thread by @MonicaGandhi9

Spoke to @fayeflam at Bloomberg last week of how vaccine memory should be long. There are many papers on this but I wanted to give you the 4 most interesting ones in this thread in my opinion.
podcasts.apple.com/us/podcast/32-…

So, we all love this paper showing the vaccines generate memory B cells (even in the lymph nodes with biopsies) although La Jolla and other places had already shown memory B cell formation in blood in other studies
nature.com/articles/s4158…

So you have memory B cells and see a variant in the future? Even if your antibodies wane (which they will, not a glitch but natural for the immune system), you have the blueprint to make more from memory B & those antibodies will ADAPT to the variant
medrxiv.org/content/10.110…

Our T cells defend us against severe disease, that is what they do
rupress.org/jem/article/21…

And T cells line up against the spike protein & no, we are not going to get a variant that evade them because there are 80-100 T cells across the spike protein & the variants have 10-12 & can't develop 100 or will be rendered nonfunctional
cell.com/cell-reports-m…

And T cells work well against all the variants- think of 80-100 soldiers lined up across spike protein, the variants knock out 10-13 of them. You still have 70-80 to fight the virus left
biorxiv.org/content/10.110…