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Sarah Constantin

@s_r_constantin

4 Aug

There’s a mode of social interaction that I really miss, and that’s “high volume/density, low expectations.”

Small talk is “low volume/density, low expectations”. You don’t expect much from it, but you also don’t spend much time or energy on it. Low information content, safe but not that fun.

An important work meeting is “low volume/density, high expectations.” You’re trying to keep it brief to respect everyone’s time. And there are high expectations that everything you say is civil, accurate, relevant, useful, non-obvious, etc.

Read 27 tweets

Sarah Constantin

@s_r_constantin

16 Jun

🧵:
One like = one piece of advice from Wine Mom Sarah to the youths

(Specific questions also welcome)

1: never invert a matrix if you don’t have to

2: when visiting colleges or interviewing for jobs, if it seems like the place is full of assholes, it probably is

Read 63 tweets

Sarah Constantin

@s_r_constantin

8 May

My current “impractical” project is building a comprehensive list of interventions that cause >20% complete tumor regression in metastatic solid tumors. Basically, the hardest of hard modes for cancer.

I don’t think I’m quite done (will put it up in a post when I’m satisfied), but here’s what I’m seeing so far.

1. There are some things I don’t expect to generalize much. Stereotactic radiation for lung metastases & intratumoral injections of Nasty Stuff for skin metastases — great where available but you can’t always access the tumors.

Read 49 tweets

Sarah Constantin

@s_r_constantin

5 May

endpts.com/focused-on-the… One of many companies trying to make cell therapy more efficient.

Cell therapy means taking cells out of a patient or donor, genetically modifying them, and putting them back in to treat a disease. CAR-T therapy does this with immune cells and has remarkable results in some cancers. But it costs $100k to produce one dose.

The potential patient population is huge; the world’s production capacity is tiny.

You effectively have to produce a custom “drug” in the hospital, for each patient.

Read 13 tweets

Sarah Constantin

@s_r_constantin

5 May

@SteveStuWill

@SteveStuWill @anderssandberg I think this article understates how big the disconnect is between how people think about charity/altruism and how they think about effectiveness or causal reasoning.

@SteveStuWill

@SteveStuWill @anderssandberg Years after being personally familiar with the EA movement I *finally* grokked, after a friend showed me some equations on paper, that these people were trying to spend LESS money to get a desired result (like lives saved.)

@SteveStuWill

@SteveStuWill @anderssandberg I had thought the point of charity was to prove you were a good person who was willing to sacrifice.

If you were going to think about it in budgeting/efficiency terms, like you would for personal consumption or business purchases, why would you give to charity at all?

Read 7 tweets

Sarah Constantin

@s_r_constantin

25 Apr

I think there are two different concepts, *favor* and *trust*, that are not the same and (maybe) shouldn’t be pushed to be the same.

🧵

You favor someone, or view them favorably, when you are motivated to be their ally, or to be on their side.

When you favor someone, you do nice things for them, defend them against others, and *show* everyone that they’re your ally.

Signs of affection, approval, affiliation, and inclusion in the group are important signals of favor.

Read 40 tweets

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