You've probably seen or heard quite a few comments about the fact that we don’t yet know the long-term consequences of COVID-19 vaccines. When vaccines have caused long-term consequences in the past, that has invariably started within a month or 2 of that vaccine dose.
1/12
The much more worrying prospect is long-term complications of the infection itself, which we don’t yet know because COVID-19 has only been around for under two years. When you catch a virus, the virus uses your cells to create new virus particles.
2/12
During the infection, that happens inside many cells, often all over your body. Not infrequently that leaves some of the virus’s genetic material in your genes. Right now, about 5 – 8% of your DNA is made up of junk DNA from viruses that you or your ancestors caught.
3/12
Below is a brief list of some of the unexpected later onset complications from viral infections we encounter.
•Measles: subacute sclerosing panencephalitis (invariably fatal at a rate of 1 in ~100,000 cases)
•Hepatitis B or C: cirrhosis of the liver and liver cancer
4/12
•EBV: various types of lymphoma, cancers at the back of the nose, post-transplant lymphoproliferative disease
5/12
•CMV: major challenges if you need any sort of organ or bone marrow transplant later on, potential for reactivation when unwell with other serious health problems later on, congenital CMV in babies
•HPV: cancers of the cervix, penis, anus or throat
6/12
•Herpes simplex 1 & 2: reactivations throughout life, encephalitis
•Chicken pox (or varicella): shingles from later reactivation of the virus
•Influenza: bad ‘flu years are always followed by a rise in heart attacks and strokes in the subsequent 1 – 2 years
7/12
•Rubella: congenital rubella syndrome in babies
•Parvovirus B19: hydrops fetalis in babies
•Human herpes virus 6: various types of organ damage (e.g., lung, liver or brain inflammation) after an organ transplant
8/12
•Human herpes virus 8: Kaposi sarcoma, some lymphomas, Castleman's disease
•Polio: post-polio syndrome
•BK virus: damage to kidneys if immune suppressed later
•JC virus: progressive multifocal leukoencephalopathy if immune suppressed later
9/12
With nearly 5 billion doses of the vaccines now given around the world, we have an enormous amount of information on their safety, effectiveness and side effects.
10/12
We know they get broken down quickly in your body so the chance of any unexpected late complications that we don’t already know about is incredibly small.
11/12
If you are genuinely worried about long-term consequences, then the much bigger concern is the long-term risks of the virus itself rather than the vaccines.
12/12

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More from @P_Charles_ID_Dr

24 Jul
The immunity you get after being vaccinated for COVID-19 looks to be better than the immunity you get after recovering from the infection. On average, the antibody levels are 10 times higher post-vaccines than post-recovery.
1/4
Plus, vaccines lead to you having antibodies only against the virus’ spike protein, the important bit for giving you protection.
2/4
When you get the infection, your immune system develops antibodies against the spike protein & also against other parts of the virus like envelope protein and some of those extra antibodies appear to contribute to some people getting more unwell when they have COVID-19.
3/4
Read 4 tweets
23 Jun
Nobody is denying that lockdowns are hard. But quite often, the negatives aspects of lockdowns are discussed without even a cursory attempt to consider what might have happened without them.
Thread 1/10
Australia has had just over 30,000 cases of COVID-19 diagnosed and tragically 910 deaths. Globally, there have been 180 million cases officially diagnosed (and clearly many more who were not officially diagnosed) and nearly 4 million deaths.
2/10
A recent study looking at unexplained deaths around the world suggests that the number of COVID-19 deaths is likely to be at least two to three times higher though.
3/10
Read 10 tweets
24 Aug 20
There has been a lot of focus on deaths related to COVID-19 but recently we have also been learning more about the degree of ongoing health problems in some of the survivors.
Thread on Long COVID 1/9
We are now aware that a proportion of patients have ongoing symptoms for longer than expected and are labelling this ‘long COVID’ when it persists for at least several months.
2/9
Some healthcare facilities have been setting up clinics for these people to try to understand better their symptoms and also gradually to learn how we can manage them.
3/9
Read 9 tweets
19 Aug 20
Some journalists, economists and politicians have been saying that we just need to let the virus run and only worry about protecting the elderly or vulnerable.
Thread 1/17
Given that would mean a lot more community infections, hopefully limited to those at lower risk of death or severe infection, let’s have a look at what it would take to try to protect those who need protecting.
2/17
The residents of aged care facilities have been hit particularly hard, so we’d obviously have to focus a lot of energy on trying to stop COVID-19 from getting into their facilities.
3/17
Read 17 tweets
7 Aug 20
Quite a few people have been asking why the restrictions and mandatory masks in Victoria aren’t getting the numbers down more quickly. There are quite a few reasons, which include:
A thread 1/14
1a.A reasonable proportion of cases are still related to the Aged Care Facilities. This can mean positive cases from the residents, the staff, and also the household contacts of the staff.
2/14
1b. As we have seen around the world, it is particularly challenging to prevent spread within these facilities when there is movement of staff and residents throughout, and many moments where people come into close contact.
3/14
Read 14 tweets
5 Aug 20
If you’re unlucky enough to be in the situation of trying to care for a household member who has COVID-19, here are some suggestions for how best to do it:
• Have the infected person in a separate room with the door closed.
1/10
• If practical, try to keep windows open to improve air flow.
• If possible, they should use a separate bathroom to others in the house.
2/10
• If there's only 1 bathroom, avoid using it straight after the infected person, and keep a window open to promote airflow. Wash down surfaces e.g., door handles, toilet seat, the flush buttons, and sink area with either bleach or alcohol-based hand rub on a dry cloth
3/10
Read 10 tweets

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