rubic3n Profile picture
24 Aug, 8 tweets, 7 min read
@NeBirgitta A Study designed for the effect of Berberine on liver cells.
Unique epigenetic modifying mechanism
"Enhances DNA methylation. Berberine induces more apoptosis, cell cycle arrest, but less ROS production."
Prior discussed effect on the energy metabolism.
researchgate.net/publication/30…
@NeBirgitta Hitting almost all the xs of what Walter has written about.
I wonder, is there something similar for other tissues, particular neural?
What has been described about dosage and pharmacological interactin with Quercetin, NAC?
@NeBirgitta So, here we go:
Berberine Protects against Neuronal Damage via Suppression of Glia-Mediated Inflammation in Traumatic Brain Injury

journals.plos.org/plosone/articl…
@GentleMutt @sandovalch
@NeBirgitta @GentleMutt @sandovalch 2021 Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota
nature.com/articles/s4139…
@NeBirgitta @GentleMutt @sandovalch Dosage in the dopa study
@NeBirgitta @GentleMutt @sandovalch Gut biome L Dopa production in the presence of oral Berberine
"Dopa/dopamine might be the chemical link for the crosstalk between gut and brain. The regulation of Phe–Tyr–dopa–dopamine biosynthesis in the gut microbiota by BBR could improve brain function"
@NeBirgitta @GentleMutt @sandovalch "Berberine Protects C17.2 Neural Stem Cells From Oxidative Damage Followed by Inducing Neuronal Differentiation"



frontiersin.org/articles/10.33…
@NeBirgitta @GentleMutt @sandovalch "Neuroprotective effect of berberine agonist against impairment of learning and memory skills in severe traumatic brain injury via Sirt1/p38 MAPK expression"
"attenuated brain edema and inhibited matrix metalloproteinase‑3 and ‑9 protein expression"

spandidos-publications.com/10.3892/mmr.20…

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More from @rubic3n

5 Sep
The Stanford prison experiment has its 50th anniversary.

A good time to remember this scary part of ubiquitous human nature.

There are no goodies or baddies.
There is no 'law enforcement by all means' for those on the self-declared good cause side.
There are elements in our closer and wider environment that have come up again and again that lead me to view it in the light that we are in this now.

In a huge revitalized 'Stanford Prison Experiment'.

With perceivably enormous funding behind it.

simplypsychology.org/zimbardo.html
Using the SPE serves to draw analogies and to have a more structured frame for analysis in this guessing game that we find ourselves in.

Why this virus? Why now? Why the governmental reactions? The role of the US and CCP? Afghanistan. So many open questions - and more.
Read 13 tweets
4 Sep
HYDROXYTYROSOL
(olive leaf extract)

Hydroxytyrosol inhibits Nuclear factor kappa β (NF-κβ) activity - chronic inflammatory diseases

Alleviates peripheral neuropathy
Antidiabetic
Perserves mitochondrial function
BBB!!

sciencedirect.com/science/articl…
HTyr activates neurogenesis in the dentate gyrus
Increasing survival of new neurons and decreasing apoptosis
Multiplication of stem cells
Reduces the markers of aging lipofuscin and Iba1 (as a product of brain aging, reduces their adverse effect)

faseb.onlinelibrary.wiley.com/doi/full/10.10…
HTyr and skin

reducing IL-1α + IL-8 release by RHE tissues
decreased the expression of IL-1β, IL-6, and IL-8 gene

GREATER THAN THE REFERENCE DRUG DEXAMETHASONE .

MMP-1 and MMP-3 by UVA were decreased dose-dependent
excellent transcutaneous absorption

link.springer.com/article/10.100…
Read 10 tweets
6 Jun
mRNA patent 2017 to Moderna and BioNtech

A network analysis of COVID-19 mRNA vaccine patents
nature.com/articles/s4158… ImageImage
CellScript sublicenced mRNA patents to Moderna BioNtech in 2017 but obfuscated clear links of entries in the database to Covid patents because it redacted the data entry. Image
Curevac, article to be reviewed app.handelsblatt.com/arts_und_style…
Read 17 tweets
5 Jun
2004
This has been an ongoing nightmare for so many years.

An ongoing nightmare.

We are locked into our anonymous semi isolated twitter boxes passing messages through gov controlled holes in the wall.

"SARS escaped Beijing lab twice"
ncbi.nlm.nih.gov/pmc/articles/P…
They orchestrate a bizarre
Münchhausen by proxy for us.

They finance story writers that dream up scenarios in which technological means can wreak most intricate havoc.
We are just the biological shovelware.
In parallel they weave a tapestry of the
disease
which they myopically reduce to a 'find a cell entry'
not caring
choosing a receptor that is so widely spread throughout our organism
so well garded as one of the enigma machines
Read 58 tweets

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