Thread by @rubic3n

@NeBirgitta A Study designed for the effect of Berberine on liver cells.
Unique epigenetic modifying mechanism
"Enhances DNA methylation. Berberine induces more apoptosis, cell cycle arrest, but less ROS production."
Prior discussed effect on the energy metabolism.
researchgate.net/publication/30…

@NeBirgitta Hitting almost all the xs of what Walter has written about.
I wonder, is there something similar for other tissues, particular neural?
What has been described about dosage and pharmacological interactin with Quercetin, NAC?

@NeBirgitta So, here we go:
Berberine Protects against Neuronal Damage via Suppression of Glia-Mediated Inflammation in Traumatic Brain Injury

journals.plos.org/plosone/articl…
@GentleMutt @sandovalch

@NeBirgitta @GentleMutt @sandovalch 2021 Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota
nature.com/articles/s4139…

@NeBirgitta @GentleMutt @sandovalch Dosage in the dopa study

@NeBirgitta @GentleMutt @sandovalch Gut biome L Dopa production in the presence of oral Berberine
"Dopa/dopamine might be the chemical link for the crosstalk between gut and brain. The regulation of Phe–Tyr–dopa–dopamine biosynthesis in the gut microbiota by BBR could improve brain function"

@NeBirgitta @GentleMutt @sandovalch "Berberine Protects C17.2 Neural Stem Cells From Oxidative Damage Followed by Inducing Neuronal Differentiation"

https://twitter.com/rubic3n/status/1430249983945609226

frontiersin.org/articles/10.33…

@NeBirgitta @GentleMutt @sandovalch "Neuroprotective effect of berberine agonist against impairment of learning and memory skills in severe traumatic brain injury via Sirt1/p38 MAPK expression"
"attenuated brain edema and inhibited matrix metalloproteinase‑3 and ‑9 protein expression"

spandidos-publications.com/10.3892/mmr.20…