HYDROXYTYROSOL
(olive leaf extract)
Hydroxytyrosol inhibits Nuclear factor kappa β (NF-κβ) activity - chronic inflammatory diseases
Alleviates peripheral neuropathy
Antidiabetic
Perserves mitochondrial function
BBB!!
sciencedirect.com/science/articl…
(olive leaf extract)
Hydroxytyrosol inhibits Nuclear factor kappa β (NF-κβ) activity - chronic inflammatory diseases
Alleviates peripheral neuropathy
Antidiabetic
Perserves mitochondrial function
BBB!!
sciencedirect.com/science/articl…
HTyr activates neurogenesis in the dentate gyrus
Increasing survival of new neurons and decreasing apoptosis
Multiplication of stem cells
Reduces the markers of aging lipofuscin and Iba1 (as a product of brain aging, reduces their adverse effect)
faseb.onlinelibrary.wiley.com/doi/full/10.10…
Increasing survival of new neurons and decreasing apoptosis
Multiplication of stem cells
Reduces the markers of aging lipofuscin and Iba1 (as a product of brain aging, reduces their adverse effect)
faseb.onlinelibrary.wiley.com/doi/full/10.10…
HTyr and skin
reducing IL-1α + IL-8 release by RHE tissues
decreased the expression of IL-1β, IL-6, and IL-8 gene
GREATER THAN THE REFERENCE DRUG DEXAMETHASONE .
MMP-1 and MMP-3 by UVA were decreased dose-dependent
excellent transcutaneous absorption
link.springer.com/article/10.100…
reducing IL-1α + IL-8 release by RHE tissues
decreased the expression of IL-1β, IL-6, and IL-8 gene
GREATER THAN THE REFERENCE DRUG DEXAMETHASONE .
MMP-1 and MMP-3 by UVA were decreased dose-dependent
excellent transcutaneous absorption
link.springer.com/article/10.100…
HTyr effect on skin aging
onlinelibrary.wiley.com/doi/10.1111/ic…
biomeddermatol.biomedcentral.com/articles/10.11…
onlinelibrary.wiley.com/doi/10.1111/ic…
biomeddermatol.biomedcentral.com/articles/10.11…
HTyr
Taking the bullet out of the gun
- inhibited prostaglandin (PG)E2 production and COX-2 expression, without affecting COX-1 and activity in human activated monocytes
mediated by
- down-regulation of phorbol ester-induced NF-κB activation
- reduces PKCα and PKCβ1 activation
Taking the bullet out of the gun
- inhibited prostaglandin (PG)E2 production and COX-2 expression, without affecting COX-1 and activity in human activated monocytes
mediated by
- down-regulation of phorbol ester-induced NF-κB activation
- reduces PKCα and PKCβ1 activation
Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health
Good Overview
HTyr can cross the BBB!
europepmc.org/article/MED/31…
Good Overview
HTyr can cross the BBB!
europepmc.org/article/MED/31…
HTyr
Promotes Proliferation of Human Schwann Cells (in vitro)
"HT stimulates the proliferation of hSCs in vitro, indicated by a significant increase in the hSC proliferation index and protein expression of hSCs' proliferation markers, p75 NGFR and GFAP"
europepmc.org/article/MED/32…
Promotes Proliferation of Human Schwann Cells (in vitro)
"HT stimulates the proliferation of hSCs in vitro, indicated by a significant increase in the hSC proliferation index and protein expression of hSCs' proliferation markers, p75 NGFR and GFAP"
europepmc.org/article/MED/32…
"Natural Polyphenols and Spinal Cord Injury SCI"
Also post injury care
Overview
ncbi.nlm.nih.gov/pmc/articles/P…
Also post injury care
Overview
ncbi.nlm.nih.gov/pmc/articles/P…
"Natural polyphenols effects on protein aggregates in Alzheimer's and Parkinson's prion-like diseases"
Main effects of cited polyphenols modulating protein aggregates
In vitro (A) and in vivo (B)
(A) nrronline.org/article.asp?is…
(B) researchoutput.csu.edu.au/ws/portalfiles…
Main effects of cited polyphenols modulating protein aggregates
In vitro (A) and in vivo (B)
(A) nrronline.org/article.asp?is…
(B) researchoutput.csu.edu.au/ws/portalfiles…
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