1/ Apoptosis (cell death) is an essential component of the maintenance process of our bodies. It is a highly controlled and regulated technique for removing unwanted cells from any organ by the process of induced metabolic suicide.
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2/ Tinkering with this process is a potentially catastrophic game. This is the game of Russian Roulette that we play when we take Statins.
That good old law of unintended consequences could have a field day here.
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That good old law of unintended consequences could have a field day here.
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3/ Statins promote apoptosis. They do it in diseased tissues - Cheers for Statins. Unfortunately they ALSO do it in NORMAL tissues too; Boo for Statins.
4/ Statins promote cell death in heart muscle. Just imagine what having heart muscle cells commit suicide does for the pumping ability of your heart. Add to that the CoQ10 depletion of Statins.
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5/ This is an additional problem, because the heart is a muscle and depletion of CoQ10 eventually leads to heart failure. Boo for Statins.
Statins also promote apoptosis in brain cells,.
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Statins also promote apoptosis in brain cells,.
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6/ Statins promote cell death in the Vascular Endothelium. Yes you read that right ! Statins block de novo synthesis of cholesterol by inhibiting HMG CoA. The product of this reaction, Mevalonic acid, is also a precursor of isoprenoids, required for the activation
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7/ of signalling G-proteins, such as Ras.
Signal transduction pathways involving Ras are important for cell survival and are why Statins induce apoptotic death of several cell types.
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Signal transduction pathways involving Ras are important for cell survival and are why Statins induce apoptotic death of several cell types.
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8/ Given that Statins are used to treat Heart disease, it is surprising that no studies have been conducted on the effect of Statins on vascular endothelial cells. However, it’s no surprise to me because there is absolutely NO money in it !
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