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Eric Feigl-Ding Profile picture
@DrEricDing
Sep 10, 2021 • 12 tweets • 5 min read • Read on X
💡BREAKING—CDC study confirms the NIH-Moderna #COVID19 vaccine is more effective against #DeltaVariant hospitalizations than Pfizer-BioNTech or Johnson & Johnson. Vaccine efficacy for Delta🏥—Moderna 95%, Pfizer 80%, J&J 60%. VE also higher in age <74!🧵
cdc.gov/mmwr/volumes/7… Image
2) “Overall, VE against COVID-19 hospital- ization was 86%. VE was significantly lower among adults aged ≥75 years (76%) than among those aged 18–74 years (89%) (Table). The difference in VE point estimates between age groups was similar for Pfizer-BioNTech and Moderna vaccines”
3) “Across all ages, VE was significantly higher among Moderna vaccine recipients (95%) than among Pfizer-BioNTech (80%) or Janssen (60%) vaccine recipients.”
4) Is this difference also true for ER visits too? Yes. For ER—“VE was highest among Moderna vaccine recipients (92%), followed by Pfizer-BioNTech vaccine recipients (77%), and was lowest (65%) for Janssen vaccine recipients (Table).”
5) What about all breakthrough infections? Well, CDC itself doesn’t track all cases nationwide. But luckily, Oklahoma tracks breakthroughs by vaccine type - and in this other report, Moderna also had the lowest vaccine breakthrough rates for total infections! Image
6) Show more proof? Moderna also produced 2.6x more antibodies against the #SARSCoV2 virus than Pfizer in another Belgian study! We think this is because Moderna’s standard dose is 100 microgram while Pfizer’s is 30 mcg. Many scientists acknowledge this + Moderna longer time gap.
7) Another study from Minnesota found an even bigger difference between Moderna and Pfizer… for breakthroughs, ➡️ Moderna had HALF as many breakthrough infections as Pfizer! Look at the graph!
8) Let’s still remember unvaccinated are still 11x more likely to die of #COVID19. Thus, any vaccine is still leaps and bounds better than no vaccine. washingtonpost.com/health/2021/09…
9) Moderna is also developing 4 variant adapted variant-specific spike vaccines! One for #DeltaVariant, one for #BetaVariant, one for Beta+Delta, and one for Beta+original!

seekingalpha.com/news/3738430-m…
10) Where else have we seen fewer breakthroughs with Moderna? DC health department also noticed it a month ago… much much lower than J&J, and somewhat lower than Pfizer.

It’s been an active debate for a while—but the clue were all there for us epidemiologists watching closely. Image
11) Moderna 3rd shot booster’s EUA is obviously coming soon. But there is a bug debate whether to EUA authorize it as a full standard 100 mcg dose or to cut it to 50 mcg dose for the booster. I hope 100 mcg! google.com/amp/s/www.wsj.…
12) excited for the new booster data from Israel. See thread 🧵 below 👇

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More from @DrEricDing

Eric Feigl-Ding Profile picture
Mar 14
I’ve said it before, and I’ll say it again… once upon a time, liberals did have our own “Leftist Joe Rogan”… his name was Joe Rogan…

Here he is advocating for socialized medicine, healthcare for all, and supporting labor unions to protect workers.
2) Recall, Rogan was once pro Obama and pro Bernie Sanders, and pro Yang Gang, and anti Trump. It’s sad he has since failed to the dark side. But like Vader… maybe he can be redeemed someday and come back to the light.
3) *Fallen, not failed (above).

Joe Rogan was also pro gay rights and pro DACA and pro helping inner city communities that suffer economic and social injustices. It’s sad what he has become. I feel we should try to pull & welcome him back someday. Everyone can be redeemed.
Read 4 tweets
Eric Feigl-Ding Profile picture
Feb 26
BREAKING—FDA suddenly cancels meeting to update next season’s flu vaccines, with zero explanations. Any delays will jeopardize next year’s vaccine supply chain. Image
2) Folks who follow me know that I’m no bullshitter. I criticized past pandemic response right and left, and have called balls and strikes without bias. And I often say things that doctors & epidemiologists are whispering among themselves but don’t say publicly. (Cough cough) ⬇️
3) While I don’t recommend hoarding… I think stocking up on flu antivirals, which you can obtain prophylactically (preventively) from doctors if you ask nicely why you’re high risk, can be a good idea. I know many doctors, epidemiologists and virologists who do for their family.
Read 6 tweets
Eric Feigl-Ding Profile picture
Feb 26
Doctors are debunking RFK Jr’s claim that 20 hospitalized measles cases in Texas are there for mainly quarantine. Doctors on the ground say the 20 kids hospitalized are having trouble breathing. Oh and they are all unvaccinated against measles, which RFK Jr neglects to mention. Image
2) RFK Jr told Trump today there’s now 2 measles deaths.
3) RFK Jr is a tear with his FDA today. A dark Darwinian future lies ahead for America.
Read 4 tweets
Eric Feigl-Ding Profile picture
Feb 26
BREAKING—Reports coming in about potentially *2 measles deaths* in Texas, not just one, according to an HHS briefing to the White House today.
2) Earlier today, one measles death in an unvaccinated child was reported in Texas. Image
3) It seems to be RFK Jr who said it in an official Trump WH cabinet meeting today. Not saying he doesn’t lie, but he is now HHS Secretary
Read 6 tweets
Eric Feigl-Ding Profile picture
Feb 21
Woke or biology? There are actually more than the basic “male” XY & “female” XX sexes. Why? Because biology also creates people with single X chromosomes, or extra chromosomes like XXX, XXY, XYY, or XXX+, plus many 🧬genes. 👉All I’m asking is— please be kind to others. Thanks🙏 Image
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2) “The most frequent SCAs include Turner syndrome (45,X), Klinefelter syndrome (47,XXY), Trisomy X syndrome (47,XXX), and Double Y syndrome (47,XYY).”

pmc.ncbi.nlm.nih.gov/articles/PMC10…
3) “The phenotype seen in SCAs is highly variable and may not merely be due to the direct genomic imbalance from altered sex chromosome gene dosage but also due to additive alterations in gene networks and regulatory pathways across the genome as well as individual genetic modifiers.”
Read 5 tweets
Eric Feigl-Ding Profile picture
Feb 16
I'm shocked a lot of doctors don't know about this newer flu antiviral drug called Baloxavir (XOFLUZA)... that shortens your flu illness by 33%, and reduces your viral load by day 2, versus what a placebo takes 5-6 days to achieve. Baloxavir also seems superior to TAMIFLU (oseltamivir) for smashing your viral load on 2 day, achieving what takes Tamiflu 3-4 days. CDC even lists Baloxavir on their website as one of the top 4 drugs that it tracks whether it works against new flu strains (it works)Image
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2) "Baloxavir was associated with significantly more rapid declines in infectious viral load than placebo or oseltamivir (Figure 3A and 3B)."
nejm.org/doi/full/10.10…
3) Adverse events for baloxavir were no different than placebo. in fact theres even hints that it could be lower than Tamiflu.

"Adverse events that were considered to be related to the trial regimen were more common in oseltamivir recipients (8.4%) than in baloxavir recipients (4.4%, P=0.009)"Image
Read 13 tweets

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