Thread by @GrimaldesJ

✅The severity of COVID-19 disease, especially in the elderly and patients with comorbidities, is characterized by hypercytokinemia, an exaggerated immune response associated with an uncontrolled and excessive release of pro-inflammatory cytokine mediators (cytokine storm).

1. The immunomodulatory capacity of flavonoids, carried out by the regulation of inflammatory mediators, the inhibition of endothelial activation, the NLRP3 inflammasome, the toll-like receptors (TLR)

2. Or the bromodomain-containing protein 4 (BRD4), and the activation erythroid-derived nuclear factor 2 (Nrf2), could be beneficial in regulating cytokine storm during SARS-CoV-2 infection.

3. Furthermore, the ability of flavonoids to inhibit ladipeptidyl peptidase 4 (DPP4), neutralize 3-chymotrypsin-like proteases (3CLpro) or affect the intestinal microbiota to maintain the immune response.
sciencedirect.com/science/articl…

4. The molecular docking of SARS-CoV-2S and fisetin🍓👇
@DrLBoominathan
researchgate.net/figure/The-mol…

5. Cellular senescence (SnCs) often develop a senescence-associated secretory phenotype (SASP). This can include proinflammatory; proapoptotic cytokines (TNF-α, IL1 α IL-6); chemokines that attract, activate, and anchor immune cells (IP-10, MCP's) ;

6. Tissue-destroying proteases (MMP-3, 9, or 12); prothrombotic factors (PAI-1); factors that impair stem cell/progenitor function and cause fibrosis (Activin-A, TGF-β-related proteins); and ferritin. In addition to proteins and peptides, the SASP can include bioactive lipids

7. (bradykinins, ceramides, PG), tissue damaging, proinflammatory, noncoding nucleotides (including micro-RNAs, mitochondrial DNA), exosomes, and other factors that contribute to tissue necrosis, fibrosis, systemic inflammation, immune dysfunction, and spread of senescence.

agsjournals.onlinelibrary.wiley.com/doi/10.1111/jg…

8. Neuroprotective👉fisetin🍎dosage (20 mg/kg, i.p for 2 weeks; 1 week prior to LPS and 1 week co-treated with LPS) markedly reduced oxidative stress, systemic inflammation, neurodegeneration, and synaptic and memory dysfunction induced by LPS
mdpi.com/2077-0383/8/6/…

Fisetin🍇abrogates the D-galactose-induced oxidative stress and neuroinflammation by regulating the inflammatory mediators and markers related to the vital process of autophagy
nmn.com/news/is-fiseti…