Here are the votes that came in! #herbals for Cisplatin-AKI #onconephrology #tweetorial
https://twitter.com/kdjhaveri/status/1435561471770042369
1. Green tea- One basic science study I found that showed some benefit in rats with cisplatin pubmed.ncbi.nlm.nih.gov/19647078/- authors postulate that green team increased the activities of the enzymes of carbohydrate metabolism, brush border membrane, oxidative stress.
2) another basic science study in rats showed the similar finding ncbi.nlm.nih.gov/pmc/articles/P…
3) here is an interesting review on effect of green tea on various renal diseases academic.oup.com/advances/artic…
4) Honey - Interestingly, honey feeding significantly reduced cisplatin-induced tubular epithelial cell death, immune infiltration into the kidney as well as cytokine and chemokine expression and excretion as compared to cisplatin treated animals. pubmed.ncbi.nlm.nih.gov/26041312/
5) Another study found that honey protects against cisplatin-induced hepatic and renal toxicity through inhibition of NF-κB-mediated COX-2 expression and the oxidative stress dependent BAX/Bcl-2/caspase-3 apoptotic pathway pubs.rsc.org/en/content/art…
6) Coffee- Kahweol is a natural diterpene extracted from coffee beans and has been shown to possess anti-oxidative and anti-inflammatory properties and it helped in fighting cisplatin induced apoptosis and necroptosis in the kidneys. pubmed.ncbi.nlm.nih.gov/33291262/
7)And this was presented at ASN Kidney Week 2020 
8) So while there may be some animal data for green tea, honey and coffee- no human data thus far.. This table is interesting and has all studied herbal therapies used for chemotherapy related renal toxicities frontiersin.org/articles/10.33…
9) In the end, perhaps make your green tea with honey or coffee with honey and decrease that oxidative stress. Maybe someone should do a RCT on this?? #onconephrology @D2Unroll
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