Long COVID is confusing until we realize its most alarming outcome is *Chronic Fatigue Syndrome* (CFS).

What does CFS look like?
Is it like Long COVID? 🧵

This is a person with CFS. At 24, she had spent nearly a decade without putting her feet on the ground.
This is @jenbrea suffering from post-exertional malaise, from her documentary Unrest, which you can watch on Netflix (the 3 clips come from the documentary)
This is Whitney, who hasn't talked for years. His father:
“Whitney’s state is comparable to an AIDS patient about a week before his death. And that has been the case for the last six years.”
CFS is an illness that leaves ppl exhausted after minimum efforts like brushing their teeth, leaves many ppl bedridden, can last for decades, and has no known cure.

The #1 cause of death is suicide.
Why am I talking about CFS in the context of Long COVID?

Long COVID can be many things, but one of the worst is "COVID Chronic Fatigue Syndrome" or "COVID CFS".

It looks eerily like "standard CFS".
Standard CFS and COVID CFS:
1.Have the same symptoms
2.Appear after a viral infection
3.Affect women more, especially those in their fertile years
4.Also seem to be caused by a combination of remaining virus and immune system gone awry
5. They're bad: Ppl lose their jobs from it
1. Same symptoms
The main symptoms of COVID after 6 months are the same as those of standard CFS (see here:
mayoclinic.org/diseases-condi… )
2. They both appear after a viral infection
In the case of standard CFS, it is known to appear after Zika, Ebola, mononucleosis, and many other virus infections, including worryingly the flu and SARS
3. They both affect women in their fertile years more
The graph is for CFS

For COVID CFS, many studies show the same: eg, a Parisian hospital had 4x as many women as men with Long COVID. More studies here:
unchartedterritories.tomaspueyo.com/p/long-covid-c…
4. They seem to share the cause
There's evidence that standard and COVID CFS might both be due to some virus persisting in the body and/or the immune system going awry
5. Both of them are so debilitating that many patients lose their jobs and get financial pbms
If it's true, it's bad, because CFS appears to be chronic and has no cure.

What are your odds of catching it? ~2-3%
Can you prevent it? Yes, vaccines help
How much?
What else do we know?

That, and more, in this week's article
unchartedterritories.tomaspueyo.com/p/long-covid-c…

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More from @tomaspueyo

14 Sep
If you catch COVID, the risk of developing COVID Chronic Fatigue Syndrome are 3,000x higher than those of suffering a bad vaccine side-effect. That illness can leave you out of work and energy for the rest of your life.
The most long-lasting part of Long COVID is likely Chronic Fatigue Syndrome, which so far has no cure and can last decades.

Your likelihood of catching it from COVID is ~2-3%, and it's worse for young ppl than old ppl

Vaccines appear to help. They probably reduce the odds of developing COVID CFS by 75-90%.
Read 6 tweets
6 Sep
I'm going to try a new experiment in 2022.

The idea is to create a cohort-based course with live lectures. I am still debating whether it should be about
1. How to solve any problem
2. Advanced product and growth mgmt

Would you be interested in any? LMK!
6pbx56333ge.typeform.com/to/yhfkHyl3
Over my career managing billion-dollar tech products with hundreds of millions of users, studying storytelling, and writing COVID and Uncharted Territories articles, I've come to think the biggest pbm of mankind is that we don't know how to make decisions.

I want to solve that.
The 3-week course would include frameworks, lectures, and more importantly, workshops so you can bring pbms to the table and we can work to solve them together, learning decision-making along the way.
Read 5 tweets
4 Sep
A majority of the world will speak English by the end of the century. This will create a new global identity. It will be the triumph of the Anywheres.

Why? Because the same mechanic happened in the past.

Here's what happened and what will happen next 🧵
Up to the 1500s, languages were not differentiated like today. In places like Europe, there were vernacular gradients, from Wallonia to Lisbon, from London to Vienna.
That's because most ppl didn't communicate with those far away from their village.
Read 16 tweets
3 Sep
Slides or write-ups? Which one is best?

According to Amazon’s Jeff Bezos, write-ups. But I never understood it until very recently.

Bezos defends why writing is better. Ironically, his write-up has all the flaws that he complains about in powerpoints:
“The narrative structure of a good memo forces better thought and better understanding of what's more important than what, and how things are related”

Ok so his hypothesis: idea importance and interconnectedness are crucial, but write-ups achieve them better.

Why?
“Ppt-style presentations somehow give permission to gloss over ideas, flatten out any sense of relative importance, and ignore the interconnectedness of ideas.”

Ok 3 causes. W/ ppt, ppl:
-gloss over ideas
-don’t make idea importance obvious
-ignore their connection

But why?
Read 11 tweets
2 Sep
Has anybody ever told you "Stop being a Jack of All Trades, Master of None"?

They're wrong

It's "Jack of Some Trades, Master of One"

This is why, and how it's the only way to become the best in the world at something. 🧵
unchartedterritories.tomaspueyo.com/p/how-to-becom…
Becoming the best in the world at some skill is nearly impossible. There's always somebody stronger than you, cleverer than you, with better genetics, who worked harder...

The more you work on standing out in a domain, the more you face these phenomenal competitors.
That's why becoming the best in the world at something takes too much work.

It's nearly impossible to be the best, but it's quite easy to be in the top 10% or so.
Read 15 tweets
30 Aug
Have you ever heard northern Europeans telling southern Europeans they're lazy?

It's false.
So why are northerners richer?

Small thread 🧵
1. Northerners work substantially LESS than southerners
2. Northerners make substantially MORE money
Here's GDP per capita PPS, indexed at 100=EU average
Read 14 tweets

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