Our newest study is out in Science!
It cover 5 COVID-19 RNA vaccine topics. Using samples from the "low dose" 25mcg Moderna RNA COVID-19 vaccine clinical trial 🧵👇🏼
science.org/doi/10.1126/sc…
By the LJI team! @Dani6020 @SetteLab @jmateust @ljiresearch
It cover 5 COVID-19 RNA vaccine topics. Using samples from the "low dose" 25mcg Moderna RNA COVID-19 vaccine clinical trial 🧵👇🏼
science.org/doi/10.1126/sc…
By the LJI team! @Dani6020 @SetteLab @jmateust @ljiresearch
The five finding summarized here:
🔵 T cell memory to an RNA vaccine at 7 months
🔵 Vaccine dose sparing (25mcg v 100mcg)
🔵 Vaccine v. natural immunity
🔵 T cell memory with age
🔵 Pre-existing crossreactive memory T cells: Do they do anything?
🔵 T cell memory to an RNA vaccine at 7 months
🔵 Vaccine dose sparing (25mcg v 100mcg)
🔵 Vaccine v. natural immunity
🔵 T cell memory with age
🔵 Pre-existing crossreactive memory T cells: Do they do anything?
🔵 T cell memory to an RNA vaccine:
Impressive T cell memory at 7 months (6 months after 2nd dose). CD4s & CD8s. Tfh & cytokine+.
Overall, looks like two doses of an RNA vaccine generates impressive T cell memory that is likely to last for many years.
Even 25mcg Moderna dose
Impressive T cell memory at 7 months (6 months after 2nd dose). CD4s & CD8s. Tfh & cytokine+.
Overall, looks like two doses of an RNA vaccine generates impressive T cell memory that is likely to last for many years.
Even 25mcg Moderna dose
@EJohnWherry has an excellent preprint with similar T cell memory RNA vaccine conclusions
https://twitter.com/rishirajgoel/status/1430148915064676352?s=20
🔵 Vaccine dose sparing
There is interest in knowing whether lower dose RNA vaccines could still expect some protective value, perhaps in lower risk populations.
Overall, 25mcg compared favorably to 100mcg. 2-fold lower antibodies and CD4 T cells, and comparable CD8 T cells.
There is interest in knowing whether lower dose RNA vaccines could still expect some protective value, perhaps in lower risk populations.
Overall, 25mcg compared favorably to 100mcg. 2-fold lower antibodies and CD4 T cells, and comparable CD8 T cells.
🔵 How do vaccines compare to natural immunity?
Immune memory to a low dose RNA vaccine compared favorably to natural immunity! Equal Spike T cells and antibodies at 7 months.
Immune memory to a low dose RNA vaccine compared favorably to natural immunity! Equal Spike T cells and antibodies at 7 months.
🔵 How is immune memory in older people?
T cell memory in older adults was at least as good as T cell memory in younger adults!
Antibodies were ~2-fold lower, as reported previously for the full dose vaccine by the NIH and Emory teams.
T cell memory in older adults was at least as good as T cell memory in younger adults!
Antibodies were ~2-fold lower, as reported previously for the full dose vaccine by the NIH and Emory teams.
Excellent earlier Moderna 7 month antibody report:
science.org/lookup/doi/10.…
science.org/lookup/doi/10.…
🔵 Pre-existing coronavirus crossreactive memory T cells: Do they do anything?
YES! This study was a key test of whether the crossreactive T cells were functional in vivo. We found they substantially improved both T cell and antibody responses to the vaccine.
YES! This study was a key test of whether the crossreactive T cells were functional in vivo. We found they substantially improved both T cell and antibody responses to the vaccine.
This is complemented by an excellent study by the Thiels and colleagues, who studied the Pfizer/BNT COVID-19 vaccine.
science.org/doi/10.1126/sc…
science.org/doi/10.1126/sc…
With those clear, independent demonstrations of positive functionality of coronaviruscrossreactive memory T cells in the controlled setting of vaccines (where the exposure is certain and defined), this study by Maini and colleagues is fascinating:
medrxiv.org/content/10.110…
medrxiv.org/content/10.110…
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