Before I wade into this, a caveat: EcoHealth's proposal was rejected by DARPA. (However that doesn’t mean they backtracked on the plan. Everything written in it makes it sound they had a framework, a plan on how to proceed.) The proposal also introduces some new material facts.
They are very clear in what they intended: bat sampling, virus characterization, high-risk experiments, captive trials on bats, and large scale inoculation of bats in Yunnan to “DEFUSE” a potential SARSr-CoV spillover. They demonstrated their capacity, and their expertise.
Now, we don't know how far things progressed beyond that point, but the absolute fact of matter is: it was their stated intent. Doesn’t mean that's what happened, but intent matters.
At the bare minimum, it's deeply problematic on multiple levels and raises enormous questions.
Let me share a not-so-far fetched scenario, just to ponder what you need to consider: China decides to go alone. They make Mojiang one of their test sites, and construct two facilities near the mine. Would love to know if this is purely coincidental:
Why David Relman and his colleagues told the world that we need to investigate both of COVID-19’s origin stories: “Listen, despite all this yakking, we actually don’t know a whole lot based on hard data. We have a lot of assumptions, but..very little data" stanfordmag.org/contents/germ-…
"[Some scientists] violated the principles of scientific investigation by saying, “Despite the fact that we don’t have much of an evidentiary basis for saying any of this, we’re going to tell you how we think this all went down.”"
"their assumption that because we haven’t heard of anything closer, there can’t be anything closer, is flawed. They continue to say that because we don’t see anything closer in a lab, it couldn’t have come from a lab."
In Y3 of EHA's grant report, the same figure is quoted: "Host-virus co-phylogeographic analysis of a diverse group of >1,300 bat CoVs showing that
these viruses have a larger host range, weaker host specificity and higher frequency of cross-genera transmission.." 2/4
However in Latinne et al. published in @Nature (2020), they only report 1,246 sequences: “Our final datasets include 630 sequences generated for this study and 616 sequences from GenBank or GISAID.” (1,229 sequences in the supplementary material) 3/4 nature.com/articles/s4146…
"All but one scientist who penned a letter in The Lancet dismissing the possibility that coronavirus could have come from a lab in Wuhan were linked to its Chinese researchers, their colleagues or funders"
"Conflicts of interest were not reported for any of the other 26 signers of the letter – not even those with obviously material undisclosed conflicts such as EcoHealth employees and Predict contractors."
"The standard remedy for fraudulent statements in scientific publications is retraction. It is unclear why retraction was not pursued.”
i) RNA extractions on 1,000 samples per year.
ii) RT-PCR assays on 1,000 samples per year.
ii) DNA sequencing on 3,200 samples per year.
Where is the data?
@Ayjchan@theintercept@MaraHvistendahl@fastlerner "We have developed primary cell lines and transformed cell lines from 9 bat species using kidney, spleen, heart, brain and intestine. We have used these for virus isolation, infection assays and receptor molecule gene cloning." cc @franciscodeasis
We had two valid covid origin hypotheses at the beginning and both should have been treated that way. Excluding one was for all intents and purposes an attack on science. It has since become clear that part of the offensive was a targeted campaign.
The media, for the most part, failed to fulfill an important task of journalism: to keep responsible institutions accountable and to keep the public up to date with the latest knowledge.
I expected the media to report the obvious inconsistencies earlier.
Scientists, by and large, failed to push for transparency, data accessibility and verifiability. If scientists have any belief in scientific principles, if it doesn't matter here, take those words out of our mouth.