Thread by @EricTopol

New large dataset of US Medicare (age 65+) population subgroup: 2.7 million Pfizer; 2.9 million Moderna vaccinated, w/ ~30,000 breakthrough hospitalizations, via claims 🧵main findings
@Humetrix humetrix.com/powerpoint-vac…

1. Definite waning of protection vs hospitalization for those 5-6 months out from vaccination (odd ratio 2.5X at 6 months)

2. No significant difference of waning for Pfizer vs Moderna for protection from breakthrough infections

3. Breakthrough hospitalizations most in oldest age groups (cumulative 2.6%, of those with infection 20% required hospitalization, 34% ICU)

4. Crude vaccine effectiveness vs hospitalization = 62%
This may be an underestimate due to this Medicare subgroup with high comorbidity and imputation for unvaccinated via CDC data sources

5. The variables associated with breakthrough hospitalizations
Most notable: Prior covid + vaccine marked protection

As far as I know, this is the largest dataset of vaccinated Americans for breakthrough hospitalizations, w/ data several months out from getting vaccinated, multiple weeks into the 4th Delta wave (with the caveats of an insurance claims resource)

I could have started the thread with BREAKING but I've never done that; these data have not been previously made public