My Exit Strategy Updated:

Not at my trading laptop so all are estimates. I plan to fade all rallies in biotech back to old high as value for the $XBI is only $112.
Pathways:

$BPMC 3.34% will keep my 2.02% paid core
$MRTX 3.34% will keep my 2.02% paid core
$TPTX 3.34% will keep my 2.02% paid core
$SDGR sell all
$RVMD sell all
$ERAS sell all
$RLAY sell all
$RTPX sell all
Protein Degraders:

$ARVN sell all
$KYMR 1.35% will keep my .67% core
$CCCC 1.35% will keep my .67% core
$GLUE 2.02% will keep my .67% core
CRISPR:

$CRBU sell all its only company in the massive bubble space I still own. I would sell it if we retest the highs for the $XBI.
Cell Therapies:

$IPSC 1.35% will keep my .67% core
$TIL 1.35% will keep my .67 core
$CABA 1.35% will keep my .67% core
$SANA 1.35% will keep my .67% core
Delivery:

$GBIO sell all
$FDMT sell all
$SANA moved to cell therapies
That would be me circling my wagons around my core position until the bubble pops as I see any realistic value on the $XBI of $112 or less. I don't mind stopping trading for a few years until the collapse. Plenty of cool science stuff to do while I wait out this blow off top.
I am keeping my watch lists active so I have a shopping list ready for when that next collapse comes like it did last spring of the pandemic. There is always the next disaster to create a better buying opportunity.

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Biotech2k

Biotech2k Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @Biotech2k1

24 Sep
#Cell_Therapies iPSC

A look at induced Pluripotent Stem Cells.
1/ This has been a huge love of mine for years. The engineering of cells to create cancer therapies. The induced Pluripotent Stem Cells (iPSC) can revolutionize the way we create CAR-T or CAR-NK cells for cancer treatments.
2/ The process of the iPSC can be automated, duplicated and consistent as a source of low cost cell therapies. So how does this work?
Read 15 tweets
22 Sep
#Molecular_Glue

A look at how molecular glue works.
1/ In previous Targeted Protein Degrader threads, I went over the basic process of how the E1 enzyme adds the phosphate group to the ubiquitin molecule. It then passes it to the E2 enzyme which binds to the E3 ligase as a complex.
2/ The E3 ligase is designed with a site of recognition that is specific to a group of proteins. These proteins, called substrates, can be many different proteins for the same E3 ligase, but they all have a specific site that the E3 recognizes and binds to.
Read 6 tweets
21 Sep
#CRISPR_DNA_Repair

A look at HDR vs NHEJ in Double Stranded Breaks.
1/ When the CAS enzyme does a double stranded break (DSB), it can be repaired by 2 different pathways. The first is the Homology Directed Repair (HDR) and the second is Non Homologous End Joining (NHEJ). Image
2/ What influences how the repair is made? This come from a few factors. The first is that NHEJ is the most dominant of the 2 repair pathways. Homology Directed Repair (HDR) is only used when a sister chromatid is available. Image
Read 15 tweets
21 Sep
1/ I know I have been critical on the value in the CRISPR space, but lately the stocks have pulled back significantly from where I sold them back in January and February. I had remarked to a friend today about possibly buying them back into any sell off.
2/ I think the values are still very extreme, but CRISPR is the defining technology of our generation. If it works, these companies will be worth 10x what they are trading for. I can't see giving up the long term potential because of the short term.
3/ I am considering just dipping a toe into a basket of them across the technology just to buy back my starter positions. Then I can be more picky about valuations and wait for the froth to die down.
Read 7 tweets
18 Sep
@HassanAesthetic Profile on Prime Editing
1/ I wanted to include this as its science needs to be understood, even though, they are technically a company with indications or even public to value. I really love the application of the science.
2/ The Prime Editing comes with 3 parts and its more of a gene writer than a base editor. It has the CAS enzyme that cuts the DNA using a single strand nickase. The guide RNA is much larger, but plays 2 roles. The first half guides the CAS enzyme to the site of the edit.
Read 10 tweets
18 Sep
@HassanAesthetic Profile for $GRPH
1/ This company uses CRISPR CAS9 in a whole new approach. They use a CAS9 enzyme along with the guide RNA to find the right place in the Genome and do a Double Stranded Break (DSB).
2/ Then they use a second AAV6 vector to deliver a template strand of DNA that the cell can use for Homology Directed Repair (HDR). I looked at this approach, and I see so many things that could go wrong.
Read 10 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!

:(