COVID Update: First data from an oral at-home anti-viral from Merck are in.

50% reduction in hospitalizations. Trial halted, EUA on the way. 1/
Game changer for COVID-19.

Will be able to be taken orally either post diagnosis or even after routine exposure. 2/
Added protection for some:
-breakthrough cases
-health care workers

Real potential for:
-countries/areas w low vaccine access or acceptance
-immunosuppressed
3/
Clinical trials demonstrated effectiveness across variants including Delta.

4/
There were 14 deaths in the placebo group and none in the group which took the anti-viral from what was reported to me of the data. 5/
There are 3 more drugs in advanced clinical trials— one with promising results. 6/
The tools to weaken COVID and make it manageable depend on oral-anti virals and other easily accessible therapies. 7/
We should begin manufacturing to flood the stores by the end of the year pending FDA approval. /end

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More from @ASlavitt

2 Oct
COVID Update: 700,000 lives lost and a nation’s soul damaged to COVID. 1/ Image
We are going through a period of extended trauma. We witnessed it all. Denial of science, a health system marked by neglect, massive disparities between rich & poor and black & white, cruelty & bullying, unmourned losses.

And then COVID happened. 2/
Our accumulated sins which have played out slowly and in shadows over many years got to be seen in high speed as the pandemic fished out suffering both cruel & levied at the many who had a harder time protecting themselves. 3/
Read 17 tweets
28 Sep
COVID Update: When vaccine requirements are announced, whether in the military, a company, or a hospital, there is attention paid to the often dozen(s) who protest.

Less attention is paid to the thousands who get vaccinated. 1/
The story is told over & over.

Hospitals in Texas and Oregon had protests & lawsuits from staff when they announced vaccine requirements early this year.

Yet a much larger a number became vaccinated. 2/
The US military, at one point 50% vaccinated, is now at 90%.

Most NCAA teams are now between 85% & 100%. The NFL 94%.

A slew of early companies who put in requirements are now at 90%. 3/
Read 19 tweets
27 Sep
COVID Update: Vaccines wane because they’re supposed to.

Millions won’t access the vaccine & billions can’t. That’s a bigger problem.

Report from talking to 3 scientists about what we’ve recently learned and what it means. 1/
The worst is not behind us. Thousands are dying each day in the US and in Africa & many remote areas of the world, they remain highly vulnerable.

Until the global situation is made top priority & the US population does better, we remain vulnerable to ongoing suffering.2/
A powerful variant upended 2021 & falling short of our vaccination goals in 2021 could preview the same challenge for 2022. 3/
Read 25 tweets
22 Sep
BREAKING: FDA approves Pfizer vaccine booster for people over 65 and those at risk of serious illness.

More here in a minute.

1/
First, you can listen to FDA Commissioner explain how she considered this decision on @inthebubblepod. 2/
What will happen next is Thursday the CDC advisory committee tomorrow will meet to make specific recommendations on how to implement this approval. Then Th or Friday, Dr Walensky will make a final decision.

They will do a few things. 3/
Read 8 tweets
20 Sep
When the GOP cited “health freedom” to make opposition to pre-existing condition protections their mainstream view a decade ago, it became only a half a step away from today’s full scale embrace of anti-science, anti-health measures. 1/
“Health freedom” is one of those phrases someone cleverly arrives at because it sounds better than “full hospitals and portable morgues.” But its without a practical difference.

What exactly am I entitled to with my health freedom?

2/
It’s a big rallying cry for major candidates.

Scott Jensen in MN, Larry Elder in CA & JD Vance in OH are untalented even as politicians go.

So 10k likes from Russian bots and @Yolo304741 are all the encouragement they need to convince themselves they’re on the right track. 3/
Read 12 tweets
18 Sep
COVID Update: The very unclear story of boosters will become clear.

I will try to sort it out. And attempt to be clear myself! 1/
The evidence for a booster shot is obvious for people as they age or are at risk. The immune response was lower to begin with & after 6 months vs Delta that adds up to risk of hospitalization. 2/
Boosters dramatically increase antibody levels. And the safety profile of the boosters is also pristine. No real side effects.

It’s a no brainer for everyone with immune system issues or a little, ah, age on them. How much age? 65? 60? 50? 40? Will get back to that. 3/
Read 25 tweets

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