BOOSTERS URGENTLY—Singapore wave spiking so hard that 50% of all hospitalizations & 32% of all #COVID19 deaths are breakthroughs—all while 98% cases asymptomatic or mild & 83% of 🇸🇬 population is 2-dose vaccinated. Vaccines work—but #DeltaVariant is risky! moh.gov.sg/news-highlight…
2) Vaccines work? Absolutely! 98.3% mild or asymptomatic. But is #DeltaVariant so severe that it can still send the rest of the 1.7% to the hospital.
3) There are currently 247 cases requiring oxygen supplementation, and 34 in the ICU. Of those who have fallen very ill, 235 are seniors above 60 years. hence why elderly need boosters.
4) Singapore 🇸🇬 relaxed its mitigation, hence now lots of younger adults are hospitalized too. It’s exponential math if you balloon total infected.
5) To be clear— if a country is 100% vaccinated, then 100% of any hospitalization would be breakthroughs too. 98.3% of SG’s surge in cases is mild or asymptomatic— but when you BALLOON the total number of cases, inevitably there will be hospitalizations.
6) the other issue is waning efficacy against infections. 47% after 5 months. But hospitalization efficacy is holding up at 88% at 5 months. But 88% isn’t 100%… and when you BALLOON 🎈 the total number infected then, you will have spillover into hospitals.
7) If there are 2 viruses, one more contagious and less severe, and one less contagious and more severe… which will sicken more? The more contagious & less severe—ballooning the denominator. Problem is— #deltavariant is both more severe and more contagious—and immunity wanes.
8) Because of the waning, we need a public database for vaccine efficacy and effectiveness. CDC is finally providing it.
BREAKING—FDA suddenly cancels meeting to update next season’s flu vaccines, with zero explanations. Any delays will jeopardize next year’s vaccine supply chain.
2) Folks who follow me know that I’m no bullshitter. I criticized past pandemic response right and left, and have called balls and strikes without bias. And I often say things that doctors & epidemiologists are whispering among themselves but don’t say publicly. (Cough cough) ⬇️
3) While I don’t recommend hoarding… I think stocking up on flu antivirals, which you can obtain prophylactically (preventively) from doctors if you ask nicely why you’re high risk, can be a good idea. I know many doctors, epidemiologists and virologists who do for their family.
Doctors are debunking RFK Jr’s claim that 20 hospitalized measles cases in Texas are there for mainly quarantine. Doctors on the ground say the 20 kids hospitalized are having trouble breathing. Oh and they are all unvaccinated against measles, which RFK Jr neglects to mention.
2) RFK Jr told Trump today there’s now 2 measles deaths.
Woke or biology? There are actually more than the basic “male” XY & “female” XX sexes. Why? Because biology also creates people with single X chromosomes, or extra chromosomes like XXX, XXY, XYY, or XXX+, plus many 🧬genes. 👉All I’m asking is— please be kind to others. Thanks🙏
2) “The most frequent SCAs include Turner syndrome (45,X), Klinefelter syndrome (47,XXY), Trisomy X syndrome (47,XXX), and Double Y syndrome (47,XYY).”
3) “The phenotype seen in SCAs is highly variable and may not merely be due to the direct genomic imbalance from altered sex chromosome gene dosage but also due to additive alterations in gene networks and regulatory pathways across the genome as well as individual genetic modifiers.”
I'm shocked a lot of doctors don't know about this newer flu antiviral drug called Baloxavir (XOFLUZA)... that shortens your flu illness by 33%, and reduces your viral load by day 2, versus what a placebo takes 5-6 days to achieve. Baloxavir also seems superior to TAMIFLU (oseltamivir) for smashing your viral load on 2 day, achieving what takes Tamiflu 3-4 days. CDC even lists Baloxavir on their website as one of the top 4 drugs that it tracks whether it works against new flu strains (it works)
2) "Baloxavir was associated with significantly more rapid declines in infectious viral load than placebo or oseltamivir (Figure 3A and 3B)." nejm.org/doi/full/10.10…
3) Adverse events for baloxavir were no different than placebo. in fact theres even hints that it could be lower than Tamiflu.
"Adverse events that were considered to be related to the trial regimen were more common in oseltamivir recipients (8.4%) than in baloxavir recipients (4.4%, P=0.009)"
⚠️WORST FLU SEASON ever since 2002-2003 when we began to track flu (red, first graph). Worst hit this year are children ages 0-4 and 5-17. ▶️We also have significantly LOWER flu vaccine uptake this year, one of the lowest flu vaccine coverages (red 3rd graph). Indisputable facts.
2) I don't need to tell you that certain US states have vastly lower vaccination rates than others. See map (lighter green, less flu vaccination coverage), and which have higher (darker green)...
If you want to see details and demographics on which state has the LOWEST flu vaccine coverage rates... the data is here. cdc.gov/fluvaxview/das…
3) It’s not just the flu that is going around… Gaines County, TX, where the epicenter of the measles outbreak is, has one of the lowest measles vaccination rates too.