Of all the terrible defenses of ivermectin fraud, I think the "but 20% of all medical research is said to be fraudulent!" angle is one of the weirdest
Firstly, it doesn't matter at all. If every house on your street is one fire, pointing at the other houses and yelling "they're on fire too!" doesn't extinguish the flames eating away at your wedding photos
Secondly, the 20% figure is a very extreme estimate. Now, I thoroughly respect Prof Ben Mol, who is the one who made that assessment, but I'm not sure I agree that the average rate is actually that high blogs.bmj.com/bmj/2021/07/05…
If we look at anonymous surveys of researchers, the rate of serious misconduct - plagiarism, outright fakery etc - is estimated to be somewhere between 3-14% journals.plos.org/plosone/articl…
It also varies widely by the area of research. Pharmaceutical companies, for all their other evils, likely almost never fake research because they are bound within a tight web of legislation
The cost to a pharma company that faked a single study could probably be measured in the billions, if not more. They do all sorts of dodgy shit, but outright fraud is, I think, extraordinarily rare
Conversely, there are areas of research where fraud is probably rampant, particularly where research is less well overseen by regulators
So while I agree that there is much more fraud than most people imagine, I don't know if I'd agree that 1 in 5 studies is fake. I'd guess it's more like 1 in 10 overall, depending on the area we're looking at
Anyway, the point is that if you care whether ivermectin works or not, it genuinely doesn't matter whether other people have committed fraud. The question is whether the fraudulent research in the ivermectin space has impacted our conclusions, and it clearly has 🤷‍♂️

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More from @GidMK

4 Oct
Lots of people have been asking me to take a look at this observational ivermectin trial from Argentina, and I thought it'd be a nice change from all the fraud so here's a bit of a thread 1/n
2/n The trial is here, and it is a fairly simple epidemiological trial comparing people who were given ivermectin with those who weren't on ICU admission/death using large-scale registries in Argentina
zenodo.org/record/5525362…
3/n I've done a brief check for fraud, and the study looks fine. Honestly, I have no real issues with this paper as is, it's just not very useful as evidence for ivermectin

Let's think about why that is
Read 14 tweets
4 Oct
For those interested in facts, there are two more fraudulent ivermectin trials with news dropping this week, at least two more with very high probability of fraud soon to come
It's also worth noting that when I talk about fraud, I'm only considering clinical and observational trials. Most of the ecological trials are so woeful that it doesn't really matter if anyone faked them, and I don't really assess basic science
Anyway, if you want to know exactly how many studies are flawed, we'll hopefully have it all up this week. Takes time to assemble this stuff working unpaid in our free time!
Read 5 tweets
2 Oct
Our big new study on the infection fatality rate of COVID-19 in developing countries is out

The news is pretty grim 🧵

medrxiv.org/content/10.110…
Throughout the pandemic, there has been an apparent contradiction - low-income places appear to have lower death rates from COVID-19 than higher-income areas

This makes no sense on the face of it
So, we looked at the infection fatality rate (IFR) of COVID-19 in every place that we could find, using antibodies to estimate the number of infections in each area and the number of registered deaths as our numerator
Read 15 tweets
25 Sep
Interesting paper. Seems to make it extremely unlikely that SARS-CoV-2 was created in a lab
It is amazing how many people mischaracterize "extremely likely" as "the only possible answer"

No, this does not mean that a lab leak is totally impossible
That being said, the appearance of very closely-related coronaviruses in non-lab settings obviously makes a natural origin quite likely, especially as there are no more closely related viruses in labs 🤷‍♂️
Read 4 tweets
23 Sep
I cannot believe the question was asked, and the response is even more absurd

No, the pandemic is not a "social construct" what utter garbage
Even the explanation of why the pandemic is "socially constructed" is total nonsense. That we may have had a different response without technology does not mean that what we are doing now is "constructed" in a philosophical sense
I mean, if the pandemic had happened 3 decades ago it's almost certain that the death toll would be FAR higher, so we might have actually had a MORE intensive regulatory response
Read 5 tweets
22 Sep
The ivermectin literature is full of fraud

What can we do about it?

Our new paper in @NatureMedicine argues that we need a systematic change to counter this issue

nature.com/articles/s4159…
The basic issue is that science works on trust. We assume that no one would ever fake a study, because it's ethically and morally indefensible, and work with that

Which makes it very easy for people to fake studies
However, people generally aren't very good at faking things. There are dozens of very simple checks you can run on data to see if it's real

Problem is, you need the data to do that
Read 5 tweets

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