When we view the outside world while standing in the ICU, it is easy to be tricked into believing that the whole world is falling severely ill.
It is true that a tiny % of children fall ill, but that % is less than 0.008 (Kerala) and is ~made up of children with comorbidity.
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Which is why if we only look at the severely ill children, we will not be able to see the massive denominator of healthy children who were not affected significantly by the virus.
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This also brings up the so-called NNT (number needed to treat). Basically it is a measure of how many people need to be vaccinated to create a better outcome in 1 person.
Obviously the fewer the better.
NNT for older people is small, but for younger people it is much more.
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Thus, the question is whether injecting hundreds of thousands of low risk healthy children will make a difference.
One must not ignore the adverse outcomes cause by vaccines, fortunately there are enough legitimate publications that show these, despite early denials.
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E.g. The risk of myocarditis is increasingly more common (as experts got over the initial tendency of universal denial) and is now estimated at near 1 : 7000.
We do not know the long term effects of this apparently “self limiting condition”. Will it lead to cardiomyopathy?
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When we give a vaccine to a small number of people, the impact of very rare but serious adverse outcomes will be small. That’s basic math. (vaccine phase 3 trials are proof)
But when the same product is endorsed for millions of people, the negative impact will be greater.
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In older age groups, this risk-benefit balance is unequivocally in favour of the vaccine. For instance, a 75 year-old is 220 times more likely to die than a 20 year-old with COVID-19.
But when we are talking about children, this equation doesn’t hold.
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Even less discussed in this context is the inability of present-day vaccines to stop nasal infection, (a significant number of which is asymptomatic). I will outline the recent Texas prison outbreak which perhaps gives the closest estimate of what will happen in a population.
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A COVID outbreak in a Texas prison infected 70% of fully vaccinated inmates and 93% of the unvaccinated.
Indirect implication: if an outbreak occurs in a classroom, 3/4 vaccinated children can get infected.
Thus, vaccination cannot be made a prerequisite for school opening.
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Will add our own observations from Kerala. The impact of “Long COVID” among children is ~nil, 23 out of 25 paediatricians said there were no cases of long COVID in their practice in Kerala.
Only one doctor saw a slight uptick, and one reported a case of IBS aggravation.
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Thus, on many counts, universal vaccination of healthy children cannot be justified. From morbidity, death, transmission and Long COVID.
I agree with Dr @DrLahariya views expressed in this article.
Optimal T cell response was detected - that is CD4 Th1 and CD8 with a high degree of polyfunctionality, covering a broad range of spike protein epitopes.
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This increased T cell breadth will help fight variants. In other words, a few viral mutations here or there will not make a difference to these T cells.
This means the virus will continue to be hunted down even if it modified its appearance to gain entry into the body.
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Such measures, taken by several nations in 2020, were justifiable due to a fear of the unknown. Now that we have 21 months of data, it is time to sit down & see if they made any difference.
We must also not forget that it is the SAME virus, regardless of fancy Greek names.
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The problem with variants of concern is two-fold.
1. They take a long time to show their true colours. Thus, by the time they are declared as VOC, modern travel would have taken them all around the world.
2. Even a single introduction is enough to infect a whole country.
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This thread shows instances of fully vaccinated people picking up (and spreading) infections. Apart from very low baseline risk, this is one more good reason why universal COVID vaccination for healthy children isn’t advisable. See UK study linked below. @GKangInd@doctorsoumya
Report of vaccinated MBBS students picking up SARS-CoV-2 virus; such clusters have been occurring.
This is not “fear-mongering” (as some allege), but an important message to the public that they can’t discard precautions just because they are vaccinated. @GargiRawat@sjacobtalk
This thread in response to query by @FaruquiNeha based on an article by @Craig_A_Spencer that essentially states vaccinated people are less likely to be infected.
While that statement is true, it doesn’t address the whole issue.👇
It can be positive, which means those with advantageous mutations get selected over others, leading to an increase in its population. Example is delta variant in the case of SARS-CoV-2 virus.
Negative selection pressure is 👇
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Negative selection pressure also occurs in evolution, it is basically the force that gets rid of the “seconds” or “imperfect products” or those who have genetic changes that are deemed unfit for long term survival of the species.
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