The study in question was preprinted in November. Published earlier this year. It's been included in over a dozen systematic reviews
And it's borked. Enormously flawed
If the journal follows the traditional academic path, they'll wait 5 years until no one cares any more and then quietly post an editorial note, hoping no one notices. Meanwhile, the study has informed clinical guidelines and patient treatment for over a year already 🤷♂️
The editor quoted talked about "the randomization problem". The problem is that the study claims to be an RCT but cannot possibly have been randomized as described. It's not some vague conjecture, it's maths, and yet nothing to be done I guess
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2/n Firstly, we've got studies that probably or definitely did not take place as described. I'd not include these in any analysis, certainly not an aggregate model
3/n We've got a few case series that are just a bit of a waste of time - without even controlling for age, these provide no useful evidence even as part of an aggregate model
Some of the ivermectin trials are just...wildly terrible
This study has been cited 23 times. Appears in the Bryant et al and other systematic reviews. And it is just very bad
The study claims to be an RCT comparing ivermectin to a control group for prophylaxis, giving either ivermectin or no prophylaxis at all to contacts of presumed COVID cases
Firstly, the study is published in a journal that has an entire page dedicated to why it's not predatory, which is, uh, not a brilliant sign. Apparently it's not a problem that they were delisted from Pubmed
I wonder at stuff like this ivermectin in Indonesia "analysis". It's such obvious, boring nonsense that is disprovable with some basic fact-checking, and yet so very popular online
Firstly, the timing of "ivermectin widely available" is wrong. Ivermectin has been "flying off the shelves" in Indonesia since April 2020, with off-label use the entire pandemic
It's pretty obvious that ivermectin has been widely available in Indonesia the entire pandemic (as it is in most places). So what's the weird shaded area about?
This paper came out recently, and it is HUGELY popular among anti-vaccine advocates who are using it to suggest that vaccines don't work
It's also very fundamentally flawed. I'm a bit surprised it was published. Some thoughts 1/n
2/n The paper is here, and it's basically a series of comparisons of publicly-available COVID case and vaccine data conducted by a Harvard professor and a high-school student (note-DO NOT BE MEAN TO THE STUDENT, NEVER BE MEAN TO STUDENTS) link.springer.com/article/10.100…
3/n The study is broken into 2 sections. In the first, the authors took @OurWorldInData info, comparing the previous 7 days of case data between countries by vaccine rates. They produced this graph, showing no relationship between vaccines and reported cases
This review of vitamin D and COVID-19 is ENORMOUSLY popular online, so I thought I'd take a look
There are serious deficiencies here. I'm actually wondering if the paper is a joke? 1/n
2/n The study is here, and it's basically a review where the authors used an anonymous aggregation website and pubmed to collate observational and ecological research into vitamin D medrxiv.org/content/10.110…
3/n As it stands, the search methodology is just...completely deficient. I would recommend the authors read the PRISMA statement and download those tools, there's just no information here to work with