It's important to note that with ideal digestion you only absorb something like 60% of the B12 RDI per servings
So for resolving deficiency, sublingual B12 may be necessary, and for maintenance 2-3 meals containing B12 are necessary to prevent deficiency
So for resolving deficiency, sublingual B12 may be necessary, and for maintenance 2-3 meals containing B12 are necessary to prevent deficiency
https://twitter.com/SolBrah/status/1452231731558428676
With bowel inflammation disorders like IBS, B12 absorption is even more impaired
It's also usually necessary to include a combination of oral methylfolate with sublingual B12 to avoid the methyl trap, especially with high doses
It's also usually necessary to include a combination of oral methylfolate with sublingual B12 to avoid the methyl trap, especially with high doses
For sublingual B12 either the activated methylcobalamin or a combination of the methylated form with adenosylcobalamin works best
Methyl-B12 drives methylation, while adenosyl-B12 is used primarily in mitochondria
Methyl-B12 drives methylation, while adenosyl-B12 is used primarily in mitochondria
Sometimes when reintroducing B12 during deficiency you'll also see a flare up of deficiency symptoms
Usually this is a sign of more severe deficiency and/or lack of proper cofactors so it must be navigated carefully in these cases
Usually this is a sign of more severe deficiency and/or lack of proper cofactors so it must be navigated carefully in these cases
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