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Turajlic Lab @ The Crick

27 Oct, 5 tweets, 6 min read

@NatureCancer

Two papers OUT NOW in @NatureCancer ‼️ What does the immune response in cancer patients look like after COVID-19 vaccination or SARS-CoV-2 infection? We present results from the #CAPTURE study. Two-part thread (vaccine & infection cohort findings) to follow... 🧵🧵 (1/4)

@royalmarsdenNHS

About the study: #CAPTURE a prospective, longitudinal cohort study established in April 2020 and conducted at @royalmarsdenNHS and @TheCrick. #CAPTUREstudy recruitment and analyses are ongoing (2/4) cell.com/cell/fulltext/…

@COVID19nCCC

CAPTURE assessed functional immunity in cancer patients – given registry studies @COVID19nCCC @UKCORONACANCER show cancer patients are vulnerable to COVID19 & vaccines induce robust adaptive immunity but may be lower in blood cancer patients @EJohnWherry @florian_krammer (3/4)

@royalmarsdenNHS

First - Huge thanks to the patients, research teams and participating units @royalmarsdenNHS, everyone @TheCrick, COVID19-Crick Consortium, HTS & @MaryYiWeiWu @kaw00011, & @annikafendler @lewisjwau @stcshepherd who led on the work🎉 Funders @royalmarsden @cancerBRC @CR_UK (4/4)

@fendler_annika

@fendler_annika

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Turajlic Lab @ The Crick

@TurajlicLab

28 Oct

@cancercell

📰Out NOW in @cancercell ‼️👉cell.com/cancer-cell/fu… 🎉What underpins anti-PD-1 response in ccRCC?

Results from ADAPTeR Phase II clinical trial, bulk/single-cell analysis of longitudinal tumour samples ⤵️(1/15) @royalmarsdenNHS @TheCrick @uclcancer

Intratumour heterogeneity (ITH) is pervasive in ccRCC & longitudinal data on anti-PD1 response is scarce 🚨 Thus we performed multi-omics analysis on 115 multiregion tumour samples, taken at baseline, week-9, & PD, from 15 treatment-naïve patients treated with nivo 🔬 (2/15)

What are the determinants of anti-PD1 response? 🤔 In keeping with other studies, no nsSNV/fsINDEL/copy number event, nor TMB/wGII (measure of chromosomal complexity) correlated with response, pre or post-nivo, even accounting for ITH (3/15)

Read 15 tweets

Turajlic Lab @ The Crick

@TurajlicLab

27 Oct

2nd paper 📰📰 Vaccine Cohort 💉 We analysed vaccine responses in 585 patients with cancer after COVID-19 vaccination, measuring neutralising responses against the original SARS-CoV-2 and variants of concern (incl. Delta) and T cell responses (1/11)

After two doses of either Pfizer-BionTech or Oxford-AstraZeneca, 83% of infection-naïve patients with cancer developed antibodies against the original strain, but only 54% of those had neutralising antibodies against Delta (2/11)

Importantly, we show that while the proportion of patients with S1-reactive antibodies is concordant to patients with NAb against WT SARS-CoV-2 it can overestimate neutralising responses against variants of concern (3/11)

Read 11 tweets

Turajlic Lab @ The Crick

@TurajlicLab

27 Oct

1st paper📰 Infection Cohort 👉We analysed neutralising and T cell responses in 118 patients with cancer, where SARS-CoV-2 infection was defined by positive PCR or antibody test. COVID-19 severity ranged from asymptomatic to severe (1/6) nature.com/articles/s4301…

Most patient with solid cancer had neutralising antibodies while blood cancer patients had reduced or absent neutralising responses (2/6)

Patients who were infected with either the original strain or the Alpha variant had neutralising responses that were reduced against the Beta and Delta variants (3/6)

Read 6 tweets

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