1 of 6:

Revisiting the original Imperial College 1st wave scenarios:

Firstly, 280 critical care beds/100k works out at 188k beds at the peak, which corresponds to 2.4m deaths, not 500k.

The 500k was later reduced to 350k, which would have given 39 critical care beds / 100k. ImageImage
2 of 6:

Secondly, notice the odd order of interventions and the curiously equal benefit of each. This is normally an indication of a thumb-suck exercise.

Surely, it would be sensible to start with the least disruptive measure first, for example, case isolation. Image
3 of 6:

And then add on more disruptive measures such as measures focussing specifically on the vulnerable.

Limiting high risk gatherings and warning the public about high risk locations such as crowded and noisy indoor venues could then be added. Image
4 of 6:

The relative benefit of each measure is not known and purely shown for illustrative purposes.

It should however become clear why countries with much lighter interventions were not necessarily much worse off than the UK.

Low cost measures might get you 80% there. Image
5 of 6:

The highest cost measures should always be added last when producing conditional scenarios using mathematical modelling.

It is quite possible that the whole world overestimated the benefit and underestimated the cost of "stay at home orders". Image
6 of 6:

Sweden, which followed more sensible mitigation measures, while keeping most businesses open also came in well below original predictions. Image
Some more details on the calcs for the UK:

The actual numbers for the 1st wave were 41,000 deaths and 3,100 critical care beds i.e. 4.6 per 100,000.

The 350k deaths comes from this paper:
thelancet.com/journals/lanmi…

350k deaths would have resulted in 39 cc beds/100k. Image

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More from @pieterstreicher

19 Oct
1 of 5:

While Thomas Kuhn suggested that we "follow the scientific community", Paul Feyerabend suggested we "follow scientific geniuses".

Galileo, Newton and Einstein embodied a rebel spirit that drove scientific innovation.

2 of 5:

Feyerabend saw science as a creative and artistic endeavour and believed that it should not limit itself to one method or constrain itself with dogmatic rules.

It is the people that put their careers and reputations on the line that transforms the history of science.
3 of 5:

If scientists act as self-righteous bullies, treating laymen as idiots, even if they are right, they should expect kick back from the community.

Instead, scientists should aim to broaden the understanding of their work and listen to the concerns of ordinary citizens.
Read 5 tweets
16 Sep
1 of 4:

A young and an old man see a lion in the veld. The young starts putting on his running shoes.

Surprised, the old man says "You can't outrun a lion!"

"I don't have to outrun the lion," said the young man, "I just have to outrun you."

@PanData19
2 of 4:

During this pandemic with multiple variants and multiple waves, 10-20% of the population might never be infected. Vaccines are not expected to increase this number by much.

Who ends up in this 10-20% matters.
3 of 4:

The mortality risk to the healthy young is 100,000x lower compared to the healthy old, and 500,000x lower compared to the old and sick.

By closing schools and hiding the young, are we not making it increasingly difficult for the old to remain in the 20% never infected?
Read 4 tweets
15 Sep
1 of 4:

If there is one unwarranted fear, it is the fear that vaccines introduce a significant mortality risk.

Sweden has 60% of its population vaccinated over the last 9 months with no excess deaths.
2 of 4:

The possibility of net harm from vaccines will most likely be limited to the young, the healthy and the recovered.

This BMJ articles looks at both sides of the argument ito vaccinating the recovered:

bmj.com/content/374/bm…
3 of 4:

This pre-print looks at the risk of cardiac adverse events for boys 12-17, post vaccination.

Further research into the severity and long-term sequelae of post-vaccination CAE is warranted.

medrxiv.org/content/10.110…
Read 4 tweets
22 Aug
1 of 7:

This week I am going for my 2nd dose of the Pfizer vax.

The vaccines are completely safe as there is no evidence of long-term adverse effects regardless of how many doses are given. The absence of evidence is the evidence of absence, one of the key principles of EBM.
2 of 7:

Vaccines are thoroughly tested for safety over many years amongst all risk groups.

For example take this Moderna clinical trial amongst pregnant women which will be completed in 2024.

clinicaltrials.gov/ct2/show/NCT04…
3 of 7:

The public can rest assured that the emergency approval of C-19 vaccines will only be upgraded to full approval once all these trials have successfully been completed.
Read 7 tweets
17 Aug
1 of 5:

C-19 vaccines will primarily reduce severe disease and death.

Vaccinating the vulnerable is key.

Vaccination does not prevent infection or transmission.

Can we all please stop putting undue pressure on young and healthy people to get the vax. Image
2 of 5:

This is from The Scientists Collective Thought Police in an article in the Daily Mouthpiece.

They are starting to get some key aspects right which is encouraging. Unfortunately the opening paragraph starts with an error.

dailymaverick.co.za/article/2021-0…
3 of 5:

The "much worse" is not apparent in excess deaths data for SA.

Everyone is fallible. This includes scientists and institutions.

The media should not only express the opinions of one particular group. Image
Read 5 tweets
8 Jul
1 of 6:

In South Africa, the poor will derive a small benefit from vaccines as immunity levels are already at 60%. The rich will derive a major benefit as immunity levels are low at 20%.

@PanData19
2 of 6:

Lockdowns were maintained to maximise the number of people getting immunity via the vaccine as opposed to the virus.

The strategy was sold on the basis that it is the only way out i.e. removing the ethical concerns regarding the costs.
3 of 6:

The costs of lockdowns are disproportionally carried by the poor. For the poor, there are hardly any benefits.

Case isolation is difficult to impossible for shack dwellers. Contacts are traced for the rich, 60% of C-19 fatalities are missed amongst the poor.
Read 6 tweets

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