Point #6: understand that individual responses to treatments will follow a normal distribution. #OW2021
Point #7: Treatment needs to be patient-focused. #OW2021
Q: Is obesity an expression of normal biological variability?
A: (paraphrase) I would liken it to autoimmune disease for which we have much more. Genes prime the individual and the environment causes permanent abnormal physiological changes that result in pathology. #OW2021
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1/ It is no surprise that Semaglutide is the bell of the pharmacotherapy ball. Let's review some key takeaways from the STEP trials to understand why SEMA 2.4 mg is so exciting.
*credit to Dr. Wadden. #OW2021
1/ Circadian Fasting: by Dr. Chow
The theme of the day => TRE researchers have a lot to say about @ethanjweiss's research. #OW2021
2/ Eating in the AM is possibly more satiating. #OW2021
3/ Early TRE, in the absence of weight loss, elicits a more optimal metabolic response: #OW2021
⬇️ insulin
⬆️ insulin sensitivity
⬇️ hunger
⬇️ BP
‼️ But is it practical?
“Obesity is a choice” is the biggest misconception we tell ourselves and our patients. Read any of the genetics or neuroscience of obesity literature, and you would quickly rid yourself of this concept. Ignorance remains an obstacle to progress.
Notably, personal responsibility still matters. It is the difference between learned helplessness and learned optimism. You do not have to be a victim. And we could do all this while appreciating that some aspects of our environment and biology are outside of our control.
Being lean is a privilege much like never suffering from cancer, Alzheimer's disease, etc. Congratulations to those who benefit from the ideal combo of genetics and environmental factors. Personally, it has never been hard for me to lose weight. For others, that is not the case.
Why you should consider a career in Obesity Medicine:
Reason #1: Essentially No Call
Yes, I occasionally have to decrease insulin because a patient’s glycemic control is improving too rapidly. I know! It’s a terrible problem to have.
Reason #2: Medication Deprescribing
How many of you get to routinely stop BP, Diabetes, antidepressants, and pain meds? Deprescribing is the new prescribing.
Reason #3: Highly Rewarding
When a patient loses weight for the first time in years. When you stop their pain meds because their knee or back stops hurting. When you throw away their CPAP because they no longer have OSA. These shared moments are special.
Anecdotes are empowering and even intoxicating for most. If you lose 100+ lbs, change the trajectory of your health, and have increased vitality it may seem like a natural step to share your miraculous discovery with others. The reality is...
2/ biological systems are complex and individuals are unlikely to respond in the same way as YOU. How do we know? We have studied it. When you look at the variation in response across different wt loss interventions, it looks something like this...
3/ Some lose a small amount of weight
Some lose a LOT of weight (maybe like you)
Some lose NO weight
Some GAIN weight
This is why we study these things and perform the scientific method. Just like in TV disclaimer: INDIVIDUAL RESPONSES MAY VARY. (gotta love @ethanjweiss' plot)