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Eric Topol Profile picture
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5 Nov, 4 tweets, 2 min read
My summary table comparing the new and highly effective anti-Covid pills, a vital step forward for prevailing over the pandemic
No head-to-head trial to know about true comparative efficacy, but key differences in mechanism and other features
So well done on this by @Dereklowe
science.org/content/blog-p…
BTW, Paxlovid is the fastest progression from a new chemical entity to proof of benefit in a clinical trial in history. Less than 2 years!

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More from @EricTopol

Eric Topol Profile picture
3 Nov
The next chapter of anti-Covid is about to start with pills that inactivate the virus, irrespective of variants. First will be Molnupiravir in a matter of weeks, then this one.
Helping to get us onto an exit ramp. science.org/doi/10.1126/sc…
@ScienceMagazine
These will add an important new layer of defense early after symptom onset w/ test positive confirmation and also, as clinical trials get completed, for known exposure
Success of the Covid pill era depends on rapid tests that are widely available, free or very inexpensive, and accurate. While the pills are coming soon, the US is still woefully unprepared for their roll out.
Read 4 tweets
Eric Topol Profile picture
30 Oct
There's currently one continental outlier: Europe
@OurWorldInData
The top 10 countries for covid cases/capital globally are all in Eastern Europe
While there has been an increase in cases in several Western European countries, it is small (per capita) relative to the previous group
Read 4 tweets
Eric Topol Profile picture
28 Oct
A new, rigorous and important study of Covid transmission—with or without prior vaccination—in 621 people with mild infections
Just published @TheLancetInfDis
thelancet.com/lancet/article…
Vaccination reduced spread, but it still occurred in household contacts (unvaxx 38%, vaxx 25%)
Viral load was assessed from 8145 respiratory tract samples for up to 20 days, irrespective of symptoms

The peak load (Delta variant) was similar for unvaccinated vs vaccinated cases, but faster clearance in the latter

All breakthrough cases were mild
From the accompanying editorial
thelancet.com/pb-assets/Lanc…
“This study unfortunately also highlights that the vaccine effect on reducing transmission is minimal in the context of Delta variant circulation”
Read 5 tweets
Eric Topol Profile picture
27 Oct
This is what a real breakthrough infection report should look like. Thanks Oregon oregon.gov/oha/covid19/Do…
People < age 60 are not "immune" from hospitalizations and deaths
J&J>Pfizer>Moderna
Currently ~1/4 of cases
We still do not have this for the US, let alone most states
In contrast, the US has only posted such data once, now 2 months outdated, and represent only ~30% of the country
covid.cdc.gov/covid-data-tra… @CDCgov
If the US ever produced and published an up-to-date, informative report, it would be a real breakthrough
Hello @HHSgov @WHCOVIDResponse @CDCgov
Read 5 tweets
Eric Topol Profile picture
27 Oct
2 new @NatureMedicine papers
First from half of US public school data
"Schools can open for in-person learning during the pandemic with minimal contribution to sustained community incidence of infections, provided other public safety measures are adopted."
nature.com/articles/s4159… Image
2nd from Japan
"We do not find any evidence that school closures in Japan reduced the spread of COVID-19."
nature.com/articles/s4159… Image
As US schools opened, kids hospital admissions "plunged".
Counter to many predictions
bloomberg.com/news/articles/… Image
Read 4 tweets
Eric Topol Profile picture
26 Oct
Young children, age 5/6-11, and vaccination dose of mRNA
Pfizer used 10 μg in their trial of 2,270 children w/ 90.7% efficacy vs symptomatic infections
Moderna used 50 μg in their trial of 4,753 children
Wondering about this 5X mRNA dose; both trials small for v rare side effects
Another issue:
We have learned that vaccine dose spacing 8-12 weeks induces a better immune response than short (3-4 week spacing). Why hasn't this been incorporated in the new trials and roll out?
The event curve for symptomatic infections in the age 5-11 Pfizer trial presented at FDA today (2 doses given, 3 weeks apart)
fda.gov/media/153513/d…
Read 4 tweets

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