So-called Blue Zones, in addition to being cherry-picked for an agenda, are concentrated in regions with no birth certificates and short lifespans.

In other words, much of what's "known" about Blue Zones could be fraud. Image
"Surveying the ‘blue zone’ of Ikaria, Chrysohoou et al. observed that the oldest-old have... a 10% illiteracy rate, an average 7.4 years of education, and a 99% rate of smoking in men."

IOW not believable as a have for supercentenarians.

biorxiv.org/content/10.110…
*haven
All of this is reminiscent of the cholesterol hypothesis: cherry-picked data used to support an agenda and that's become so embedded in theory and practice that no amount of data will convince the experts otherwise.

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More from @Mangan150

10 Oct
SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: Implications for microclot formation in COVID-19

Fibrin resistant to fibrinolysis (clot dissolving) is a feature of many inflammatory diseases.
medrxiv.org/content/10.110…
Iron is involved in both hypercoagulation and hypofibrinolysis

Free iron does this but level of free iron depends in part on total body iron.

academic.oup.com/ib/article-abs…
Amyloid blood clots, i.e. abnormal clots, are seen in both type 2 diabetes and Covid

link.springer.com/article/10.118…
Read 4 tweets
6 Oct
My article, "Iron: an underrated factor in aging", has been published by the journal Aging.

I hope that this article will bring attention to the role of iron in healthspan and lifespan.

I'm also quite happy they agreed to publish it.
aging-us.com/article/203612
"iron satisfies many of the conditions we might look for in a universally pro-aging substance. It accumulates with age; it is associated with many age-related diseases such as cardiovascular disease, cancer, and Alzheimer’s disease;"
"it catalyzes the formation of cellular junk molecules and helps to prevent their turnover; removal of iron from plasma may be rejuvenating; and people with lower levels of body iron – blood donors – have a lower mortality rate."
Read 5 tweets
5 Sep
Over age 60, half the population has metabolic syndrome, and plenty of younger people have it too. And this was >5 years ago.

Metabolic syndrome is the very definition of leaving yourself open to acute and chronic disease.

Yet health authorities don't talk about this.
People with metabolic syndrome have 7 times the risk of having a Covid diagnosis

pubmed.ncbi.nlm.nih.gov/32924000/
People with metabolic syndrome have 3-6 times the rate of cardiovascular death

pubmed.ncbi.nlm.nih.gov/11315831/
Read 4 tweets
16 Aug
How deadly is Covid?

John Ioannidis of Stanford University estimates 2.4% IFR in community dwelling elderly, age >70

Estimate is 5.5% among elderly overall, which means nursing home residents had much higher death rates

medrxiv.org/content/10.110…
Ioannidis estimates an infection fatality rate of 0.05% among those under 70.

But that's *everyone* under 70, including those with comorbidities.

ncbi.nlm.nih.gov/pmc/articles/P…
We know (according to the CDC) that 95% of those who died from Covid had at least one underlying health condition, such as obesity, hypertension, and diabetes

Read 4 tweets
15 Aug
Aging is characterized by decline in autophagy, the cellular self-cleansing process that eliminates junk molecules.

Why does this happen?

Accumulation of lipofuscin - age pigment - which is insoluble, essentially gumming up the machinery. febs.onlinelibrary.wiley.com/doi/full/10.10…
Eventually this leads to the "garbage catastrophe of aging", in which cells do not function properly. tandfonline.com/doi/abs/10.117…
Increased autophagy is essential for extension of lifespan and healthspan.

Decreasing lipofuscin could prevent this.

Eliminating lipofuscin rejuvenates cells.

jci.org/articles/view/…
Read 7 tweets
8 Aug
Top 10 papers that influenced my thinking

There are literally millions of scientific papers

These papers that form how I think about health and fitness easily came to mind, in no particular order

(by request)
Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review

Shows that the higher the cholesterol, the longer one lives

bmjopen.bmj.com/content/6/6/e0…
Insulin Resistance as a Predictor of Age-Related Diseases

Shows that insulin resistance is strongly related to chronic disease like heart disease and cancer
academic.oup.com/jcem/article/8…
Read 11 tweets

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