How deadly is Covid?

John Ioannidis of Stanford University estimates 2.4% IFR in community dwelling elderly, age >70

Estimate is 5.5% among elderly overall, which means nursing home residents had much higher death rates

medrxiv.org/content/10.110…
Ioannidis estimates an infection fatality rate of 0.05% among those under 70.

But that's *everyone* under 70, including those with comorbidities.

ncbi.nlm.nih.gov/pmc/articles/P…
We know (according to the CDC) that 95% of those who died from Covid had at least one underlying health condition, such as obesity, hypertension, and diabetes

So it appears that if you're under 70 and have none of these conditions, i.e. you're reasonably healthy, risk of death from Covid is quite low

.05% x (1-.95) = .0025%, or 1 in 40,000

Even if not completely healthy, it's still 1 in 2000

And you have to get it in the first place

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More from @Mangan150

5 Sep
Over age 60, half the population has metabolic syndrome, and plenty of younger people have it too. And this was >5 years ago.

Metabolic syndrome is the very definition of leaving yourself open to acute and chronic disease.

Yet health authorities don't talk about this.
People with metabolic syndrome have 7 times the risk of having a Covid diagnosis

pubmed.ncbi.nlm.nih.gov/32924000/
People with metabolic syndrome have 3-6 times the rate of cardiovascular death

pubmed.ncbi.nlm.nih.gov/11315831/
Read 4 tweets
15 Aug
Aging is characterized by decline in autophagy, the cellular self-cleansing process that eliminates junk molecules.

Why does this happen?

Accumulation of lipofuscin - age pigment - which is insoluble, essentially gumming up the machinery. febs.onlinelibrary.wiley.com/doi/full/10.10…
Eventually this leads to the "garbage catastrophe of aging", in which cells do not function properly. tandfonline.com/doi/abs/10.117…
Increased autophagy is essential for extension of lifespan and healthspan.

Decreasing lipofuscin could prevent this.

Eliminating lipofuscin rejuvenates cells.

jci.org/articles/view/…
Read 7 tweets
8 Aug
Top 10 papers that influenced my thinking

There are literally millions of scientific papers

These papers that form how I think about health and fitness easily came to mind, in no particular order

(by request)
Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review

Shows that the higher the cholesterol, the longer one lives

bmjopen.bmj.com/content/6/6/e0…
Insulin Resistance as a Predictor of Age-Related Diseases

Shows that insulin resistance is strongly related to chronic disease like heart disease and cancer
academic.oup.com/jcem/article/8…
Read 11 tweets
6 Aug
Whenever you say that some allegedly incurable chronic illness was cured by diet, exercise, fasting, or some other natural means, you always see a large contingent of people who insist that's not possible, or that it's really "remission", or that it won't work for everyone.
No one says it will work for everyone.

That can't possibly be an objection to trying it, or trying to spread the word about the possibility of a cure.

By objecting to this, these people are doing serious harm
Because these objections can make people feel they shouldn't try to fix themselves.
Read 6 tweets
6 Aug
Higher levels of omega-3 acids in the blood increases life expectancy by almost five years

Huge result, though association only - causation not shown

I want to show how this implicates seed oils in mortality

sciencedaily.com/releases/2021/…
Original paper

Similar results have been seen in several other studies.

While this is framed as benefits of consuming fish or fish oils, the omega-3 index also depends on the consumption of omega-6, abundant in seed oils academic.oup.com/ajcn/advance-a…
Omega-3 index is a measure of the amount of omega-3 in red blood cells

When omega-6 consumption is high, omega-3 index is low

Omega-3 fatty acids EPA and DHA in tissues decreases with higher omega-6 content Image
Read 5 tweets
5 Aug
Long-term NAC treatment attenuated flu-like symptoms. 2 x 600 mg NAC per day for 6 months, most subjects >65 years old.

25% of those taking NAC reported symptoms vs 79% of placebo.
N-acetylcysteine is cheap and is, for now, OTC, though the FDA is trying to restrict it. Amazon has removed NAC for example.
Read 4 tweets

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