Top 10 papers that influenced my thinking

There are literally millions of scientific papers

These papers that form how I think about health and fitness easily came to mind, in no particular order

(by request)
Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review

Shows that the higher the cholesterol, the longer one lives

bmjopen.bmj.com/content/6/6/e0…
Insulin Resistance as a Predictor of Age-Related Diseases

Shows that insulin resistance is strongly related to chronic disease like heart disease and cancer
academic.oup.com/jcem/article/8…
Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease

Shows that there's no evidence that dietary saturated fat is associated with coronary heart disease
academic.oup.com/ajcn/article/9…
Ferritin levels, inflammatory biomarkers, and mortality in peripheral arterial disease

Shows how body iron stores correlate with heart disease, cancer, and mortality
sciencedirect.com/science/articl…
Evidence-Based Resistance Training Recommendations

Cuts through the noise and shows which resistance training methods have scientific backing, and how the best training is simple, time-efficient - and intense

pure.solent.ac.uk/en/publication…
Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73)

Blows the lid off a failed study in which men given seed oils to replace dietary saturated fat had *higher* death rates
bmj.com/content/353/bm…
Essential role for autophagy in life span extension

Shows that all processes that extend lifespan and healthspan use autophagy, the cellular self-cleansing process promoted by fasting and exercise
ncbi.nlm.nih.gov/pmc/articles/P…
The underappreciated role of muscle in health and disease

More muscle means better health and longer life

academic.oup.com/ajcn/article/8…
Aging and Immortality: Quasi-Programmed Senescence and Its Pharmacologic Inhibition

Classic paper by @Blagosklonny, who has not only made a major contribution to the study of aging but has also to its clinical application with rapamycin
tandfonline.com/doi/abs/10.416…
Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol

Reversal of diabetes in *one week* through energy restriction alone
link.springer.com/article/10.100…

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with P. D. Mangan Health & Fitness Maximalist 🇺🇸

P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @Mangan150

6 Aug
Whenever you say that some allegedly incurable chronic illness was cured by diet, exercise, fasting, or some other natural means, you always see a large contingent of people who insist that's not possible, or that it's really "remission", or that it won't work for everyone.
No one says it will work for everyone.

That can't possibly be an objection to trying it, or trying to spread the word about the possibility of a cure.

By objecting to this, these people are doing serious harm
Because these objections can make people feel they shouldn't try to fix themselves.
Read 6 tweets
6 Aug
Higher levels of omega-3 acids in the blood increases life expectancy by almost five years

Huge result, though association only - causation not shown

I want to show how this implicates seed oils in mortality

sciencedaily.com/releases/2021/…
Original paper

Similar results have been seen in several other studies.

While this is framed as benefits of consuming fish or fish oils, the omega-3 index also depends on the consumption of omega-6, abundant in seed oils academic.oup.com/ajcn/advance-a…
Omega-3 index is a measure of the amount of omega-3 in red blood cells

When omega-6 consumption is high, omega-3 index is low

Omega-3 fatty acids EPA and DHA in tissues decreases with higher omega-6 content Image
Read 5 tweets
5 Aug
Long-term NAC treatment attenuated flu-like symptoms. 2 x 600 mg NAC per day for 6 months, most subjects >65 years old.

25% of those taking NAC reported symptoms vs 79% of placebo.
N-acetylcysteine is cheap and is, for now, OTC, though the FDA is trying to restrict it. Amazon has removed NAC for example.
Read 4 tweets
4 Aug
Berberine prevents atherosclerosis in animals through improved gut barrier function and reduced inflammation.

This tweet is not about berberine.
Intestinal barrier dysfunction as a therapeutic target for cardiovascular disease

But, they told us it was all about cholesterol

pubmed.ncbi.nlm.nih.gov/32986965/
Read 4 tweets
1 Aug
Seed oils and cancer

High intake of omega-6 PUFAs is implicated in cancer of the breast, colon and, possibly, prostate

Omega-3 PUFAs and monounsaturated fatty acids such as oleic acid (omega-9) are protective.

pubmed.ncbi.nlm.nih.gov/10590211/
Mammary tumorigenesis [in mice] was very sensitive to linoleate [seed oils' main component] intake and increased proportionately in the range of 0.5 to 4.4% of dietary linoleate.
cancerres.aacrjournals.org/content/45/5/1…
Most Americans consume enough seed oils that they're above a plateau in cancer causation. In other words, they're exposed to the maximum cancer-promoting amount.

This may be why associational studies are inconclusive: almost no one consumes a low level of linoleic acid
Read 4 tweets
28 Jul
Seed oils (aka vegetable oils) and atherosclerosis leading to coronary heart disease

How could that work?

Let's take a look 👇
Oxidized LDL cholesterol is thought to play a critical role in formation of arterial plaques

Macrophages (white blood cells in the blood vessel wall) sense oxLDL, engulf it, leading to plaque formation

hindawi.com/journals/omcl/…
The oxidized fatty acid in oxLDL is mainly linoleic acid, the main component of seed oils

sciencedirect.com/science/articl…
Read 8 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!

:(