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19 Nov, 7 tweets, 4 min read
Health Canada approved the Pfizer-BioNTech vaccine for kids 5-11 today. 🥳

NACI has also provided recommendations on how best to use the vaccines, including dose interval.

Let’s discuss why they recommend at least 8 weeks between doses.

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#ScienceUpFirst Why at least 8 weeks between COVID-19 vaccines for kids? (N
You may have noticed that Health Canada authorized the COVID-19 vaccine with doses 3 weeks apart. But NACI is recommending doses at least 8 weeks apart.

@GovCanHealth: canada.ca/en/health-cana…

NACI: canada.ca/content/dam/ph…

Why the difference?

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#ScienceUpFirst
Health Canada authorizes vaccines based on clinical trial data. Pfizer tested the vaccines with 3 week intervals, so that’s what Health Canada approved. ✅

🧵 [3/7]

#ScienceUpFirst
NACI recommends how best to use authorized vaccines.

At least an 8 week interval may contribute added efficacy and safety for kids on an already very safe, effective and high-quality vaccine.

🧵 [4/7]

#ScienceUpFirst Shorter intervals between doses of COVID-19 mRNA vaccines re
In adult populations, extending the interval between doses appears to give higher immune response and better protection that lasts longer (4).

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#ScienceUpFirst
Myocarditis and Pericarditis are potential rare adverse side effects of mRNA vaccines.

A larger interval between doses (at least 8 weeks)

+

A lower dose (10 mcg)

Is expected to further reduce this already small risk (2).

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#ScienceUpFirst
Have questions about vaccines for children 5-11? Let us know!

References: tinyurl.com/SUFKidDoseInte…

🧵 [7/7]

#ScienceUpFirst Let’s Review! - Health Canada authorizes vaccines based o

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More from @ScienceUpFirst

ScienceUpFirst | LaScienced'Abord Profile picture
19 Nov
What are the differences between the vaccine for people 12+ and the vaccine for those 5-11?

Check out our quick guide!

🧵 [1/8]

#ScienceUpFirst Comparing the Pfizer-BioNTech vaccines Adult vaccine, for p
Both vaccines are safe and effective. ✅💉

Both use mRNA as the active ingredient. ✅💉

What’s different?

🧵 [2/8]

#ScienceUpFirst
The colour of the vial cap is different. 👀

- 12+ vial has a purple cap 🟣

- 5-11 vial has an orange cap 🟠

🧵 [3/8]

#ScienceUpFirst
Read 8 tweets
ScienceUpFirst | LaScienced'Abord Profile picture
19 Nov
BREAKING: Health Canada authorizes use of the Pfizer-BioNTech COVID-19 vaccine in children 5 to 11 years of age. 💉

Keep reading for more information.

🧵 [1/8]

#ScienceUpFirst This just in: Health Canada authorizes use of Pfizer-BioNTec
Health Canada has completed a thorough and independent scientific review of the evidence. They have determined that this vaccine is safe and effective at preventing COVID-19 for children between 5 and 11 years of age.

🧵 [2/8]

#ScienceUpFirst
In the Phase 2/3 clinical trial, the Pfizer-BioNTech vaccine was 90.7% effective at preventing symptomatic #COVID19 in children 5 to 11 years of age.

This is great news for the 2.88 million children aged 5 to 11 in Canada. 👏

🧵 [3/8]

#ScienceUpFirst
Read 8 tweets
ScienceUpFirst | LaScienced'Abord Profile picture
10 Nov
Have questions about long COVID? Well we’ve put together a looooong thread to answer them!

Here’s what we know about Long COVID so far.

References at the end!

🧵 [1/13]

#ScienceUpFirst Long COVID (While most fully recover from COVID-19, some pe
“Long COVID” is the name coined by patients, often referred to as "long haulers."

Other terms include “post COVID-19 condition” by the WHO and “post-acute sequelae of COVID-19 (PASC)” by the CDC.

They all refer to versions of the same condition.

🧵 [2/13]

#ScienceUpFirst
.@GovCanHealth's definition:

“Symptoms persisting or recurring for weeks after acute COVID-19 illness... further broken down into:

- post COVID-19 conditions occurring 4-12 weeks (short term)
- and >12 weeks (long-term) after COVID-19 diagnosis.”

🧵 [3/13]

#ScienceUpFirst
Read 13 tweets
ScienceUpFirst | LaScienced'Abord Profile picture
3 Nov
On the fence about fighting the flu? 🤔

Well get off the fence and get on defense! Getting the flu shot is extra important this year. Keep reading to find out why.

References at the bottom of the thread!

🧵 [1/10]

#ScienceUpFirst Flight the Flu! (During a pandemic, it is extra important t
Silver lining to 2020? The flu season was very mild (1). We can thank public health measures like physical distancing, reduced travel, masks and hand-washing for that.

Here’s why things are different this year...

🧵 [2/10]

#ScienceUpFirst
Reason 1: We’re seeing more people face to face. (Yay!) 👭

Reason 2: Low flu rates during the past two seasons means our population immunity against influenza is lower than usual (2). (Not yay!) 🤒

🧵 [3/10]

#ScienceUpFirst
Read 10 tweets
ScienceUpFirst | LaScienced'Abord Profile picture
2 Nov
Side of fries? 🍟 Yes!
Vaccine side effects? 💉 Pass!
Luckily, neither last long.

Keep reading to learn why doctors are confident in the safety of the COVID-19 vaccines, even long term.

Refs at the end!

🧵 [1/12]

#ScienceUpFirst Concerned about long-term side effects of the COVID-19 vacci
Medications can have long-term effects, but vaccines work differently.

Medication is often taken daily for years.

Vaccines are given infrequently. For COVID-19, this means 1 or 2 doses, and then possible future boosters.

🧵 [2/12]

#ScienceUpFirst
If you take certain medications every day, side effects may occur over time.

Vaccine ingredients don’t stick around your body. They drop in, chat with your immune system, and then disappear. We’re talking minutes to hours (3)!

🧵 [3/12]

#ScienceUpFirst
Read 12 tweets
ScienceUpFirst | LaScienced'Abord Profile picture
18 Oct
Did you know that not all scientific evidence is equal? 🤔

The more the study is influenced by the expert, the higher the risk of bias.

Check out this thread for an explanation of the hierarchy of evidence 🔺

🧵 [1/6]

#ScienceUpFirst Hierarchy of evidence. A pyramid with 6 levels, with the lea
Studies with a low risk of bias ✅:
1. Systematic reviews and meta-analyses
2. Randomized controlled trials

🧵 [2/6]

#ScienceUpFirst Systematic Review/Meta-analysis: - Systematic reviews use al
Studies with a moderate risk of bias 🤔:

3. Cohort studies
4. Case control studies

🧵 [3/6]

#ScienceUpFirst Cohort Studies: - A cohort study takes place over an extende
Read 6 tweets

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