There is nothing wrong with having open and honest conversations about the data. That doesn’t mean I’m an anti-vaxxer. I’ve had both doses, and I recently had my flu shot as well. Please don’t be afraid to discuss strengths and weaknesses of the booster data.
Name calling is for people who can’t come up with good counter arguments but feel the need to opine. Name calling is not science. Debating the data is science.
I’ve been through this already with the lab leak theory, which I found to be a plausible origin in January of 2020. A lot of people tried to shame me on social media, but you don’t conduct an investigation by immediately declaring one plausible option as conspiracy.
If you decide an option is conspiracy before conducting any sort of unbiased, fact finding investigation, I would say that you are the conspiracy theorist.
You can call me names all you want on here. I understand it comes with the territory, and I’ve grown thick skin after everything I have been through thus far in my career.

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More from @sesiegler

22 Nov
There are some interesting points in the Tecartus sBLA documents. #CARTcells

📌 formulation volume change

📌 BCA did not last past 12 months

📌 IL-6 was the only biomarker identified for both CRS Grade 3 and above AND NT Grade 3 and above

📌 Numerous trial variables ImageImageImage
📌 3 of the 29 sites were inspected — including the 2 sites with the most important protocol deviations: Moffitt; Emory; and UChicago

📌 Insufficient MRD assay data for review by CDRH

📌 PROs were not assessed as part of the sBLA ImageImageImageImage
📌 retreatment data from ZUMA-3 were heavily redacted

📌 FDA identified 3 major trial design issues with ZUMA-3

📌 extrapolation to pediatric population was not possible ImageImageImage
Read 5 tweets
7 Sep
Hey, @PeterDaszak, why did you redact a peer reviewed publication from your biosketch? That’s very odd. documentcloud.org/documents/2105… ImageImageImageImage
This granted @NIHFunding application is about 200 pages shorter than our P01 resubmission, just for perspective.
That bat lady also redacted her biosketch. If these are @NIHFunding projects, they will be in @NIH RePORTER. It’s very odd to see peer reviewed publications and current grants redacted. What are they trying to hide?
Read 6 tweets
31 Mar
This list price is more than double the ICER valuation on the CAR. I don’t think the European health authorities are going to green light this CAR at this price. I don’t see Europe paying over $200,000/dose since they don’t care about @NIH fees and/or royalties. $BLUE $BMY
This also highlights a much bigger problem with CARs, esp. for solid tumors. It’s a problem we have always prepared for at SES but could hurt our competitors that plan to charge over $400,000/dose. In solid tumors, if the CARs aren’t curative, they have to be really cheap!
The CARs won’t be curative in solid tumors initially — esp. for the first CARs approved for solid tumors — so companies that think they can charge $400,000+/dose are going to be in for a rude awakening. It’s hard to justify that price tag for next gen CARs. #CARTcells
Read 5 tweets
30 Mar
I am going to add FDA BPCA trial design SME assembly participant to my biosketch. It’s close to being on a working group.
I kept my camera off today as I have wet hair from my shower. I recall Marisa Mayer being criticized for going to a meeting with wet hair, and hence, I kept my camera off. I will ensure I’m camera ready for the next assembly meeting.
Read 4 tweets
30 Mar
Are you a part of this SME group, @davidcnorrismd?
Trial design and biostats folks, your expertise is needed. DM me for details on how to join this SME group. #biostats #trialdesign #bayesian #ChildhoodCancer
Read 5 tweets
30 Mar
Random thought of the day: cosmetic producers for the most part remain clueless when it comes to the environment. Case in point is the new @jaclyncosmetics packaging. If companies don’t start choosing more sustainable packaging, they are going to lose customers IMHO.
I don’t care if your packaging is pretty; the only people who care about that are the YouTube influencers. I do care if your packaging is going to take hundreds of years — if not more — to break down in a landfill.
Large, clunky polymer based compacts are the worst. I am increasingly trying to avoid brands that use this type of packaging.
Read 4 tweets

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