"the approach. will be targeted to a specific pathogen, but It Is applicable to several different pathogens. For example, an approach may be used to develop therapeutics against 20 different pathogens"
3. Professor Ron Taylor
This project started in May 1996 at the University of Virginia. Taylor and his colleagues developed a heteropolymer that functions on the one end to connect to the CR 1 site of the red blood cells, while the other end is tailored to the specific pathogen.
4. Mesenchymal Stem Cells
DARPA also funded research into mesenchymal stem cells (MSCs) modified to have surface receptors designed for specific pathogens. When pathogen is detected, part of cell's DNA Is turned on to produce a gene protein product targeted to kill the pathogen
5. Strategy
To address specific Biological warfare agents, we will fund work at facilities such as USAMRIID, where actual bioagents are. kept. to determine If the therapeutics are effective In animal models.
6. Pharmaceutical Industry
DARPA will provide the thrust & the biotech industry & pharmaceutical industries will take over these products (clinical testing & development) to commercialize them for their own purposes.
DoD will then procure them via "normal" commercial routes
7. Unconventional Pathogen Countermeasures
"The most sinister offensive biological warfare scenario employs surprise, Immediate proximity &
rapidly lethal, persistent agents in overwhelming quantities"
BAA 97-23 Pathogen Countermeasures
Program Manager: CPR Shaun Jones, MD,USN
8. Advanced. Diagnostics
Program Manager: Dr. Stephen Morse
BAA 97-24 Advanced Diagnostics for Pathogens
9. Red Blood Cell Pathogen Decoy & Destruction
University of Virginia
Boston University - Mark Bitensky birensky@enra.bu.etlu
10. Sequential Auto Vaccination by Stem Cells
Daniel R. Marshak
dmarshak@osiristx.com
OSIRIS Therapeutics, Inc. .
Baltimore, MD
You have a radically new idea for fighting pathogens that colleagues are dubious about
Where would you go for funding?
To the NIH?
NIH would ask a committee of peers to evaluate it who can be brutal about radical concepts
12. Scripps - DARPA - Lerner
Richard Lerner, president of The Scripps Research Institute, another DARPA adviser, notes that the agency needs to keep in mind that ''you never know what you want to discover until you discover it."
DARPA was unable to locate any documents concerning "human cellular platforms used for biological warfare therapy," as you requested.
DARPA advises that this division does not exist, nor does DARPA have such a research program
14.Synthetic Polio
DARPA failed to inform anyone that one of its “unconventional” projects was $US300,000 ($393,939) to fund a trio of scientists who thought it would be a neat idea to synthesise polio.
They constructed the virus using its genome sequence, which was available on the Internet, and obtained the genetic material from companies that sell made-to-order DNA.
But building up the long chain of DNA from smaller pieces proved frustratingly difficult. Eventually, Dr. Cello simply ordered most of the completed sequence from a scientific supply house, Integrated DNA Technologies of Coralville, Iowa
DARPA provided $300K over the last 3 years for the work
''Understanding the process of viral DNA production is key to identifying new ways to kill viruses & understand how viruses could change & escape from vaccines"
Turning and turning in the petri dish,
The scientists cannot hear the warnings;
Genes recombine; the barriers cannot hold,
Evil virology is loosed upon the world,
The blood-dimmed tide is loosed, and everywhere
The ceremony of innocence is drowned;
The best lack critical thinking, while the professors
Are full of furious bias.
Surely some revelation is at hand;
Surely the cover up is now banned?
Lab Leak! Hardly are those words out
When a vast image out of Human Folly
Troubles my sight:
3. Somewhere in Wuhan
somewhere in the cell lines of a Chinese laboratory
A shape with pangolin body and the head of a bat,
A gaze blank and pitiless as the sun,
Is moving its long tongue, while all about it
Reel shadows of the indignant molested bats.
🧵As promised, here is my counter critique & rebuttal of some points made by @gadboit about the Pangolin Papers Hypothesis.
His theory seems to be that SARS-COV-2 emerged like Aphrodite, from BANAL BAT viruses, possibly with some FCS tweaking & no Pangolins coronaviruses needed.
@gadboit 🧵2. @gadboit claims BANAL-52’s 96.8% similarity & ACE2 binding make it closer to SARS-CoV-2 than PCoVs (~91%) & that PCoV features could come from bat CoVs.
But GD PCoV’s RBD (97% identity) needs no mutations for hACE2, unlike BANALs.
A. “The Pangolin Papers” presents a robust argument for the lab-mediated origin of SARS-CoV-2, particularly centered on experiments conducted at the Wuhan Institute of Virology (WIV) during 2018 and 2019.
1. A Modest Proposal for the Fair Imprisonment of Women and the Liberation of Men
By a Concerned Citizen of Reason,
Published in The Rational Gazette on X
March 24, 2025
2. Dire Injustice!
It is a lamentable truth, oft repeated in the progressive broadsheets and the sanctimonious halls of modern discourse, that the state of our prisons reveals a dire injustice.
3. Gaol'd Wretches
We are told, with furrowed brows and trembling voices, that Black men, comprising a mere 4% of the good people of England and Wales, yet numbering 13% of our gaol’d wretches, suffer under the cruel yoke of systemic discrimination.
@Ticklicker56 @angie_rasmussen @Dissenting2020 @DrStrangeLovett @Rebecca21951651 @All_New_to_This @VaughnMises @R_H_Ebright @Florin_Uncovers @ban_epp_gofroc @MJnanostretch @Muller_Lab @SolidEvidence @ydeigin @ciukzwil @tgof137 @StavaRune @VBruttel @FondueMean @tom335363 @BioSRP @stevenemassey @jbloom_lab @BallouxFrancois @Ayjchan @mattwridley RML expertise in biodefense inlcudes tick & flea agents, so I doubt she would want to discuss how many ticks they have or what they inject them with.