Was immer noch viel zu wenig Leute (auch Ärzte) wissen:

Wir haben hier in Deutschland Antikörper-Medikamente verfügbar, die vielen #Covid19-Patienten bei früher Gabe das Leben retten könnten.

Kurzer Thread mit ein paar Basics, bitte RT

Antikörper sind winzige Y-förmige Moleküle, die von Immunzellen im Blut hergestellt werden und Viren erkennen, blockieren und für die Zerstörung markieren können.
Die Impfung soll den Körper zur Bildung eigener Antikörper anregen (aktive Immunisierung). Bei Antikörper-Medikamenten werden künstlich hergestellte Antikörper gegen das Virus direkt als Infusion gegeben (passive Immunisierung).
Es gibt verschiedene solche Präparate, die gegen #sarscov2 entwickelt wurden und die in Deutschland zugelassen und verfügbar sind.
Hier ist eine sehr gute Übersicht aus dem Ärzteblatt:
Eingesetzt wird zurzeit vor allem Regeneron’s Cocktail von Casirivimab und Imdevimab weil er in Deutschland verfügbar und zugelassen und gegen die Delta-Variante wirksam ist.
Die Gabe von Antikörpern macht vor allem dann Sinn, wenn jemand keine eigenen Antikörper hat, also umgeimpft ist oder auf die Impfung nicht angesprochen hat.
In der Recovery-Studie etwa reduzierte sich die Sterblichkeit in der Patientengruppe, bei denen zu Beginn keine eigenen Antikörper nachweisbar waren, von 30% auf 24%. medrxiv.org/content/10.110…
In der Praxis heißt das:
Diese Medikamente werden vor allem bei Patienten eingesetzt, die ein erhöhtes Risiko haben und die entweder nicht oder nicht vollständig geimpft sind oder bei denen eine mangelnde Immunantwort nachgewiesen oder zu erwarten ist.
Infografik des RKI:
Wichtig ist, dass die Medikamente möglichst früh in der Infektion gegeben werden also am besten vor dem Beginn von Symptomen oder innerhalb der ersten Woche nach Symptombeginn.
Hier ist eine Liste des RKI von Krankenhäusern in Deutschland, in denen diese Medikamente gegeben werden:
Auch niedergelassene Ärzte können die Medikamente verabreichen.
Hier ist zum Beispiel eine Liste von Praxen in Berlin:

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More from @kakape

24 Nov
Our new @pandemiapodcast episode is out and it’s a bit of a thriller ranging from bird flu fears to burner phones.

Episode in German is here and long thread (sorry, not sorry) in English to come:
The episode is really a tale of two viruses, a story of what @JeremyFarrar told me were “the two times I've really been frightened in my professional life”.

The first moment is on the eve of Vietnamese New Year, Têt, in January 2004 in Ho-Chi-Minh City.
That night Farrar (who had been working in Vietnam since 1995) and his colleague Professor Hien were called to see a young girl who had been admitted to the hospital with a severe but unusual pneumonia.
The fear on everyone’s mind: Could SARS have returned?
Read 22 tweets
18 Nov
To all my international colleagues:
Your German word of the day (and the next weeks) is “Hospitalisierungsinzidenz” or “7-Tage-Hospitalisierungsinzidenz” to be very German…
This is essentially the number of hospitalized #covid19 patients per 100,000 per week
(with patients counted for the week their case was notified not when they were hospitalized)
and it’s now the variable that will be used to decide what level of measures is instituted.
If Hospitalisierungsinzidenz in a state is

3-6: Events will only be open to vaccinated and recovered peope (2G)
6-9: Events will only be open to vaccinated and recovered peope who also have a negative test (2G+)
>9: further measures may be added (if state’s parliament agrees)
Read 6 tweets
17 Nov
Kudos to Lothar Wieler, head of @rki_de (essentially Germany’s CDC), who had some very candid words for politicians today about the current #covid19 situation in Germany:

@rki_de Wieler started by telling them that of today's 52k notified cases (given CFR of 0,8%), about 400 will die.
“Everyone listening needs to realise: this cannot be changed”, he said. "None of us sitting here can help these people. That is a bucket of water that has been spilled."
@rki_de Already normal patient care is impacted in every region of Germany, Wieler told them:
Surgeries are being postponed, ambulances are spending an hour or two searching for a bed for stroke patients, children who need an ICU bed are being transferred far away.
Read 12 tweets
13 Nov
“WHO’s call for social science expertise, only to appoint more scientists, shows at best wilful ignorance of politics and political expertise or, at worst, active contempt.”
Do read this well-argued piece by @clarewenham, @DrJRMoon and @DrSophieHarman!

“Given everything we have learned about the role of social science in pandemic governance in the last 20 months (or indeed the last 20 years), the lack of political science (or social science more generally) expertise on SAGO represents a major gap in knowledge…”
“conducting an investigation under the microscope requires a myriad of both technical and political competencies. Not least, it requires an understanding of the politics of the institutions and states under investigation, to understand the context in which results are delivered.”
Read 4 tweets
28 Oct
The other issue I wanted to bring up in this new article is a question that I find fascinating: How may being a social media celebrity influence researchers going forward?

As @M_B_Petersen told me there is clearly a risk of being influenced by your followers’ likes. “Scientists are humans as well and humans like to get positive feedback, they like to be celebrated”, he told me. “That’s just how social media works”
Petersen told me that he saw some signs of this already. “In the beginning, everyone was just trying to figure out what is going on,” he told me. “Now, scientists are more and more locked into a particular position.”
Read 4 tweets
28 Oct
Some scientists have become twitter celebrities in this pandemic - bringing power as well as hate.
I talked to @devisridhar - a constant presence in my twitter feed the last two years - about her experience

Story here,short thread to come:
First of all: This story is part of a @NewsfromScience series on the “new normal” and just a brief peek at some of the issues scientists are grappling with in this time of viral posts and a pandemic virus. It’s a huge topic and I want to hear more stories and see more research…
But briefly:
One of the most amazing things early on in this pandemic was watching science (and policy) debates play out in real-time online. Some researchers have helped hundreds of thousands of people make sense of what’s going on and make informed decisions. They saved lives.
Read 10 tweets

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