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P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
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25 Nov, 6 tweets, 2 min read
The Clot Thickens - Dr. Malcolm Kendrick, by @RootCauseDoctor

Malcolm Kendrick has destroyed the lipid hypothesis of heart disease and left it dead in the water.
rootcausemd.substack.com/p/the-clot-thi…
I recently finished reading "The Clot Thickens", and am now rereading it a 2nd time.

It's that good.
Interesting thing about Dr. Kendrick's theory that coagulation is directly related to heart disease is that it applies to other chronic diseases also, e.g. cancer. onlinelibrary.wiley.com/doi/full/10.11…
Alzheimer's

"The present paper proposes the hypothesis that hypercoagulation might amplify MetS associated insulin resistance, neuroinflammation, BBB disruption, and amyloid beta accumulation which eventually leads to AD."
nature.com/articles/s4136…
My favorite: iron increases hypercoagulability. academic.oup.com/ib/article-abs…
Hyperfunction generally is the proximal cause of aging. ncbi.nlm.nih.gov/labs/pmc/artic…

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More from @Mangan150

P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
25 Nov
Exercise capacity is a strong, inverse predictor of all-cause death rates. Men in the highest quartile (fourth) of exercise capacity had from 1/4 to 1/3 lower risk of dying during several years follow-up.

Exercise was more important than BMI or blood lipids.
ahajournals.org/doi/10.1161/CI…
Among men referred for exercise testing, those in the lowest quintile (fifth) of exercise capacity had 4.5 times the risk of dying during 6 years of follow-up.
Read 4 tweets
P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
20 Nov
With the banning of trans fats from hydrogenated vegetable oils, did you ever wonder how they continue to make Crisco and other shortenings? I did.
They're made via a process called interesterification, which turns triglycerides solid at room temp.

Interesterified fats may be no more safe than trans fats, and may be responsible for a rise in cardiovascular deaths since 2011.

ncbi.nlm.nih.gov/labs/pmc/artic…
Unfortunately, no one seems to know how much of this stuff is being used, but it appears to be in lots of processed foods, especially baked goods.

They increase blood viscosity leading to increased thrombosis (blood clotting).
Read 7 tweets
P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
17 Nov
Men have ~5 times the rate of heart attack and heart disease in middle age, compared to women.

Hypothesis is that it's due to rheological properties of blood, and that regular blood donation can fix this. Image
Essentially, women have blood that has a higher proportion of newer RBCs, as do blood donors.

content.iospress.com/articles/clini…
Direct relation between blood viscosity and insulin resistance.

Idea is that high viscosity means blood can't properly perfuse muscle, which is where 80% of glucose goes. pubmed.ncbi.nlm.nih.gov/9535148/
Read 14 tweets
P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
9 Nov
So-called Blue Zones, in addition to being cherry-picked for an agenda, are concentrated in regions with no birth certificates and short lifespans.

In other words, much of what's "known" about Blue Zones could be fraud. Image
"Surveying the ‘blue zone’ of Ikaria, Chrysohoou et al. observed that the oldest-old have... a 10% illiteracy rate, an average 7.4 years of education, and a 99% rate of smoking in men."

IOW not believable as a have for supercentenarians.

biorxiv.org/content/10.110…
*haven
Read 4 tweets
P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
10 Oct
SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: Implications for microclot formation in COVID-19

Fibrin resistant to fibrinolysis (clot dissolving) is a feature of many inflammatory diseases.
medrxiv.org/content/10.110…
Iron is involved in both hypercoagulation and hypofibrinolysis

Free iron does this but level of free iron depends in part on total body iron.

academic.oup.com/ib/article-abs…
Amyloid blood clots, i.e. abnormal clots, are seen in both type 2 diabetes and Covid

link.springer.com/article/10.118…
Read 4 tweets
P. D. Mangan Health & Freedom Maximalist 🇺🇸 Profile picture
6 Oct
My article, "Iron: an underrated factor in aging", has been published by the journal Aging.

I hope that this article will bring attention to the role of iron in healthspan and lifespan.

I'm also quite happy they agreed to publish it.
aging-us.com/article/203612
"iron satisfies many of the conditions we might look for in a universally pro-aging substance. It accumulates with age; it is associated with many age-related diseases such as cardiovascular disease, cancer, and Alzheimer’s disease;"
"it catalyzes the formation of cellular junk molecules and helps to prevent their turnover; removal of iron from plasma may be rejuvenating; and people with lower levels of body iron – blood donors – have a lower mortality rate."
Read 5 tweets

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