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Eric Feigl-Ding Profile picture
@DrEricDing
Nov 25, 2021 • 18 tweets • 10 min read • Read on X
⚠️BREAKING—HOTEL CROSS TRANSMISSION OF #B11529—Traveler from South Africa🇿🇦 flew to Hong Kong🇭🇰 with new variant—but wasn’t discovered until 4th day of quarantine on 2nd PCR. Another guest across hallway cross-infected—only positive on 8th day on 4th PCR! Both Pfizer vaccinated🧵 Image
2) the viral load of these two with #B11529 in Hong Kong hotels were VERY high. PCR Ct values of 18 and 19!!! That’s insanely high considering they were negative on recent PCR tests. Damn, looks like vaccine evasion could be real with this variant.
3) and hell yes it’s very airborne. The hotel guests were in different room across the hallway from each other. Environmental samples found the virus in 25 of 87 swab across both rooms.
4) I think border and travel restrictions make sense. Especially since Hong Kong 🇭🇰 only caught the case because of a mandatory hotel quarantine. Which countries in the west still have that??? Almost none.
5) This #B11529 variant is bad bad bad. Scientists worldwide are worried. It has a very bad spike mutation profile and it is spreading fast across South Africa 🇿🇦— see thread 🧵 below 👇
6) 32 mutations in one spike protein is helluva a lot. Its “extremely high”. And it has real concerns because of the bad nature of these mutations too.
7) South Africa 🇿🇦 health leaders are extremely worried about #B11529. We expect the WHO will issue a new Greek name to it soon - likely the #NuVariant.
8) the #B11529 Nu variant seems to have a lot of antibody escape properties— escape in multiple epitope classes of the antibody. This is a really bad thing.
9) the spread across South Africa is quite sudden and widespread… and change from 1% positivity to suddenly 30% in a week!
10) cases still low but this surge in #B11529 is no joke. Take it seriously. Image
11) Let’s finally look at the relative growth plotted by @jburnmurdoch - cases of #B11529 surging much faster than Delta. Caveat is that cases are low. But this would be very worrisome if confirmed in the coming days and weeks. Stay tuned. Stay safe. 🙏 Image
12) 500% more infectious for #B11529 is jaw dropping if it is true. Let’s hope the early data is wrong. We actually REALLY REALLY want this early data to be wrong … because if it’s not wrong… it’s cataclysmic. See new 🧵 below.
13) Experts estimate that South Africa 🇿🇦 is already 72% infected. Natural infection clearly isn’t enough to stop #B11529 currently.
14) Israel’s testing has now found 3 cases of #B11529 - the second country outside of Africa to have identified it. This is bad. Israel 🇮🇱 and HK are very strict. I just worry for the non strict quarantine and entry testing countries now.
15) If you have found my threads 🧵 helpful, the please consider subscribing for special updates in near future:

➡️ drericding.substack.com
16) Latest models suggest #B11529 could be as much as 500% more infectious. That is indescribably bad. See thread 🧵
17) The new name for the #B11529 variant is OMICRON—which the @WHO warns has higher risk of reinfection! #Omicron
18) WHO mentioned reinfection risk (ie natural infection not a good idea)— it’s based on lots of research in bad mutations among the 32 mutations that #B11529 #OmicronVariant has in its spike protein.

Figure by @jbloom_lab.
jbloomlab.github.io/SARS2_RBD_Ab_e… Image

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More from @DrEricDing

Eric Feigl-Ding Profile picture
Feb 26
BREAKING—FDA suddenly cancels meeting to update next season’s flu vaccines, with zero explanations. Any delays will jeopardize next year’s vaccine supply chain. Image
2) Folks who follow me know that I’m no bullshitter. I criticized past pandemic response right and left, and have called balls and strikes without bias. And I often say things that doctors & epidemiologists are whispering among themselves but don’t say publicly. (Cough cough) ⬇️
3) While I don’t recommend hoarding… I think stocking up on flu antivirals, which you can obtain prophylactically (preventively) from doctors if you ask nicely why you’re high risk, can be a good idea. I know many doctors, epidemiologists and virologists who do for their family.
Read 6 tweets
Eric Feigl-Ding Profile picture
Feb 26
Doctors are debunking RFK Jr’s claim that 20 hospitalized measles cases in Texas are there for mainly quarantine. Doctors on the ground say the 20 kids hospitalized are having trouble breathing. Oh and they are all unvaccinated against measles, which RFK Jr neglects to mention. Image
2) RFK Jr told Trump today there’s now 2 measles deaths.
3) RFK Jr is a tear with his FDA today. A dark Darwinian future lies ahead for America.
Read 4 tweets
Eric Feigl-Ding Profile picture
Feb 26
BREAKING—Reports coming in about potentially *2 measles deaths* in Texas, not just one, according to an HHS briefing to the White House today.
2) Earlier today, one measles death in an unvaccinated child was reported in Texas. Image
3) It seems to be RFK Jr who said it in an official Trump WH cabinet meeting today. Not saying he doesn’t lie, but he is now HHS Secretary
Read 6 tweets
Eric Feigl-Ding Profile picture
Feb 21
Woke or biology? There are actually more than the basic “male” XY & “female” XX sexes. Why? Because biology also creates people with single X chromosomes, or extra chromosomes like XXX, XXY, XYY, or XXX+, plus many 🧬genes. 👉All I’m asking is— please be kind to others. Thanks🙏 Image
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2) “The most frequent SCAs include Turner syndrome (45,X), Klinefelter syndrome (47,XXY), Trisomy X syndrome (47,XXX), and Double Y syndrome (47,XYY).”

pmc.ncbi.nlm.nih.gov/articles/PMC10…
3) “The phenotype seen in SCAs is highly variable and may not merely be due to the direct genomic imbalance from altered sex chromosome gene dosage but also due to additive alterations in gene networks and regulatory pathways across the genome as well as individual genetic modifiers.”
Read 5 tweets
Eric Feigl-Ding Profile picture
Feb 16
I'm shocked a lot of doctors don't know about this newer flu antiviral drug called Baloxavir (XOFLUZA)... that shortens your flu illness by 33%, and reduces your viral load by day 2, versus what a placebo takes 5-6 days to achieve. Baloxavir also seems superior to TAMIFLU (oseltamivir) for smashing your viral load on 2 day, achieving what takes Tamiflu 3-4 days. CDC even lists Baloxavir on their website as one of the top 4 drugs that it tracks whether it works against new flu strains (it works)Image
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2) "Baloxavir was associated with significantly more rapid declines in infectious viral load than placebo or oseltamivir (Figure 3A and 3B)."
nejm.org/doi/full/10.10…
3) Adverse events for baloxavir were no different than placebo. in fact theres even hints that it could be lower than Tamiflu.

"Adverse events that were considered to be related to the trial regimen were more common in oseltamivir recipients (8.4%) than in baloxavir recipients (4.4%, P=0.009)"Image
Read 13 tweets
Eric Feigl-Ding Profile picture
Feb 14
⚠️WORST FLU SEASON ever since 2002-2003 when we began to track flu (red, first graph). Worst hit this year are children ages 0-4 and 5-17. ▶️We also have significantly LOWER flu vaccine uptake this year, one of the lowest flu vaccine coverages (red 3rd graph). Indisputable facts. Image
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2) I don't need to tell you that certain US states have vastly lower vaccination rates than others. See map (lighter green, less flu vaccination coverage), and which have higher (darker green)...

If you want to see details and demographics on which state has the LOWEST flu vaccine coverage rates... the data is here.
cdc.gov/fluvaxview/das…Image
3) It’s not just the flu that is going around… Gaines County, TX, where the epicenter of the measles outbreak is, has one of the lowest measles vaccination rates too.
Read 7 tweets

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