Discover and read the best of Twitter Threads about #OmicronVariant

Most recents (24)

Y tras el anterior, aquí segundo "hilo" intentando arrojar luz para tener más información ante el incremento de #COVID19 en España y más allá causado #OmicronVariant : consejos sencillos (aunque, ojo,... no exhaustiva) algunos consejos por si os resultan útiles.
Abro hilo nuevo
En hilo anterior decía que, en cuanto a la gravedad de la enfermedad que puede llegarse a desarrollar, ... es importante considerar el estado de vacunación de la persona infectada.
Las personas vacunadas, sobre todo aquellos que tienen un refuerzo (hablamos de 3ª dosis, no de más refuerzos), tienen mucha menor tendencia a complicarse y sus síntomas son más leves... 👍
Read 12 tweets
Daily Bookmarks to GAVNet 01/15/2022 greeneracresvaluenetwork.wordpress.com/2022/01/15/dai…
Doomsday Glacier in Antarctica Could Collapse Soon: New Research - Rolling Stone

rollingstone.com/politics/polit…

#ThwaitesGlacierCollapse, #antartica, #IceShelf, #ClimateChange
America’s Divisions May Have Passed the Tipping Point

reason.com/2021/12/27/ame…

#PartisanPolitics, #tribalism, #polarization, #TippingPoint, #CivilWar
Read 20 tweets
Ik denk dat te weinig mensen dit zich realiseren, maar met de opkomst van de omicronvariant is de mortaliteit nog maar de HELFT ivm de laatste heftige influenzavariant (2018).

Hiermee vervalt überhaupt elke onderbouwing voor zelfs de meest simpele maatregel. Het land MOET open!
De influenzavariant van 2018 had 'n mortaliteit van ≈ 1 op de 1000.

Van eerdere SARS-CoV-2 varianten was dit ≈ 5 op de 1000.

De mortaliteit van #omicronvariant ligt volgens de laatste grote onderzoeken ≈ 8-10x lager dan de deltavariant. Dat betekent zo'n ≈ 1 op de 2000!
Bijvoorbeeld bij dit onderzoek in Californië waar ik eerder over tweette. De mortaliteit van de omicronvariant was volgens dit onderzoek nog maar 0,09x die van de deltavariant (-91%).

Bij dit grote onderzoek kwam er zelfs NIEMAND met #Omicron op de IC.
Read 4 tweets
Wat een verademing nu net op @op1npo ? Is dit dan nu eindelijk het keerpunt?
Zapte per ongeluk op op1 met mijn vrouw.
Mona Keijzer. 98% heeft nauwelijks klachten, zelfs van de oude variant. (Roepen de '#wappies al bijna 2 jaar. Zie beruchte RIVM piramide. Ze zegt ook nog iets over grondrechten.
Read 8 tweets
1/

New research shows that only 10% #Omicron cases are in ppl who have gotten #COVID19 #Booster.

This may be MISINTERPRETED as:

"Only 10% of people w/ #BoosterDose get #OmicronVariant"

OR

#BoosterShots are 90% effective"

Not that simple! READ ON!

medrxiv.org/content/10.110…
2/

First, this is NOT a critique of the study (currently a pre-print).

Researchers at @MethodistHosp who did this provided a VERY valuable piece of info and are not making any inappropriate claims. Great work!

It's just that it's easy for public/media to misinterpret results!
3/

Paper reports on a total of 1313 #OmicronVariant cases in the Houston, TX area.

See table below:
~49% of cases in those not vaccinated (0 or 1 does)
~51% are #BREAKTHROUGHS.

Of those #Breakthrough cases,

535 cases w/ 2 #vaccine doses
140 cases w/ 3 doses (i.e., booster) Image
Read 18 tweets
Can confirm dashboard report in our NE Ohio county @bhrenton @jeremyfaust. For as long as I live I’ll never forget my gen surg call/rounds this weekend. We’ve all become somewhat numb to our #COVID19 reality over the past few years but this new situation is pure dystopian - a 🧵
As I join the surgical resident for rounds I notice a sparsely populated nursing station/floor with strange faces. Most nurses have left or are currently sick. Military personnel in full combat fatigues roam the halls changing waste bins, assisting in patient transport - 2/7
I see a familiar face in one patient room, an anesthesia (CRNA) colleague retooled to the floor since all non-emergent surgeries have been cancelled for weeks - she fiddles with a stoma appliance and laughs nervously - 3/7
Read 7 tweets
07-JAN-2022 UPDATE
1/13

Short but NOT sweet update on #COVID19 hospitalizations in 🇺🇸 children/teens.

National update in this 🧵 with data thru 06-Jan - H/T @JasonSalemi

Visit our interactive dashboard to see data for every state.

#epitwitter #PedsICU
covkidproject.org/hospitalizatio…
07-JAN-2022 UPDATE
2/13

There were 3,142 children 0-17 years old hospitalized with #COVID19 on 06-Jan-2022. This is MORE THAN TWICE as many as were hospitalized on 04-Sept-2021 at the peak of the #DeltaVariant surge.

#OmicronVariant #LongCovidKids
covkidproject.org/hospitalizatio…
07-JAN-2022 UPDATE
3/13

Pediatric bed-days for #COVID19 inpatient hospitalizations of kids 0-17 yrs have now surpassed 400,000.

That is counting only from summer 2020 - first wave hospitalizations of children in spring 2020 are not recorded anywhere.

covkidproject.org/hospitalizatio…
Read 13 tweets
The peer-reviewed version of our manuscript describing the broadly neutralizing sarbecovirus antibody S2K146 can be found here

science.org/doi/10.1126/sc…

1/5
Here is the original thread describing these results.



2/5
Compared to our original @biorxivpreprint submission, we added data showing that S2K146 binds the reconstructed RBD ancestor of all sarbecoviruses (AncAsia)

3/5 Image
Read 6 tweets
Some imp insights into #omicron by Dr Jacob John , 🧵@naveenthacker & @vipintukur
🚨Probably #Delta plus 🦠 is t last major mutation that occurred at human level
🚨Delta plus caused syncytia formation in 🫁 that resulted in multinucleated cell which incited more damage of 🫁
3.this mutant is going to remain for ⬆️ period & in turn may be an endemic 🦠 .
4. Newborns may not hv immunity like influenza 🦠 & ‘may’ req regular 💉 .
5.#Omicron is not a variant (probably) but a deviant. In t sense it is antigenic shift , probably derived frm infected 🐀
🚨the mutations in #OmicronVariant mimicked that of 🐀 antigen .
🚨#omicron pathology is not like syncytia but like endocytosis
🚨hence t damage is insignificant and will not affect alveoli and hence no hypoxia, lung damage
🚨⬆️affinity to pharynx , leading to throat pain.
Read 5 tweets
Con @AurelianoStingi abbiamo il piacere di parlarvi del nuovo #vaccino pan-coronavirus contro #COVID19 (già fatto e scritto da lui per Repubblica Salute ma repetita iuvant). Eccovi il 3d!1/n 🧵
Intro. È vero fino ad oggi, anche se non aggiornati a #Omicron, i #vaccini funzionano. Ma se si vuole pensare all'eradicazione del #virus, allora non possiamo fare altro che attendere questo vaccino, ormai in fase avanzata (trial di fase 2/3 inizia in questi mesi). 2/n
Premessa. Il nostro organismo monta una risposta immunitaria sulla base di un 'identikit' fornitogli dal vaccino o dal virus naturale. In caso di numerose mutazioni, il sistema immunitario risulta meno efficiente nel riconoscere il virus (o una sua parte come la Spike). 3/n
Read 11 tweets
There's "going to be a continued rise in cases" of #COVID19 due to the #OmicronVariant, says @POTUS at start of #COVID19 response team briefing.
The unvaccinated are displacing others who need access to hospitals, according to @POTUS.
"There's no excuse for anyone being unvaccinated," adds @POTUS.
Read 8 tweets
⭐T CELLS SUPERSTARS ⭐ Qualche dato davvero interessante e importante da riportare su immunità cellulo mediata contro #Omicron. Vediamoli in questo 3d. Avanti tutta. 1/n
#COVID19 #tcells
Dalle ultime evidenze scientifiche sembrerebbe che la variante di SARS-CoV-2 Omicron (B.1.1.529), fortemente mutata, sarebbe in grado di eludere una frazione sostanziale delle risposte anticorpali neutralizzanti.
2/n
Le quali risposte sono stimolate dagli attuali vaccini con un conseguente aumento delle infezioni ed una riduzione nell'efficacia (non della protezione) del vaccino. 3/n
Read 10 tweets
A lot of discussion about B.1.640.2 reported from Southern France 🇫🇷 and a preprint on the variant medrxiv.org/content/10.110…
This 🧵is to summarize what we know. 👇
🔴14 changes including N501Y and E484K, & 9 deletions in Spike
🔵B.1.640 (now renamed B.1.640.1) had been in the @WHO watchlist for quite some time (Nov 2021)
🔵Index case seemingly was from Cameroon (doesn't mean it originated there)
🔴Many of the mutations are shared with VoCs
🟢Though predates omicron, sequences have not grown rapidly
🟢 Mutation specific qPCR assays can screen and differentiate from Delta and Omicron
🔴We don't know whether the increasing cases in South France 🇫🇷 are associated with the new variant
Read 8 tweets
#Covid19 #OmicronVariant

🔴 Concern over Omicron spread among over-50s, says Nadhim Zahawi
🔴 Schools closing in 2020 was ‘painful lesson,’ says education secretary
🔴 MPs due to review plan B upon return to Commons on Wednesday

Follow latest⬇️ independent.co.uk/news/health/om…
🔴 Bin collections cancelled amid staff shortages
🔴 Israel to reverse travel ban imposed after Omicron

Follow latest ⬇️ independent.co.uk/news/health/om…
What are symptoms of #Omicron variant?

Read here ⬇️ independent.co.uk/news/health/om…
Read 5 tweets
The @whca board met in emergency session this evening and “unanimously approved a motion to temporarily return” the @WhiteHouse briefing room to 14 seats due to the #OmicronVariant surge.
Temporary @WhiteHouse briefing room seating chart, effective Monday, as coordinated by @whca.
“Importantly, standing in the aisle is not welcome at this time, to allow a limited number of pooling still photographers to be socially distanced,” @whca President @stevenportnoy informs members.
Read 6 tweets
Direi un fantastico contributo del team @CVRinfo guidato da @emcat1: in questo thread viene dimostrato come #OmicronVariant possa aver cambiato il modo in cui entra all'interno della cellula. Interessantissimo. Partiamo.
1/n 🧵
gla.ac.uk/researchinstit…
#Covid
#SARSCoV2 può entrare in due modi, entrambi richiedono l'attivazione della spike da parte delle proteasi.
1°: fusione della superficie cellulare, innescata da serina proteasi TMPRSS2.
2°: fusione endosomiale, innescata dalle catepsine. Finora SARS-CoV-2 ha seguito la 1°. 2/n
A tal proposito, è stato possibile utilizzare #pseudotipi di linee cellulari in cui predominano l'una o l'altra o entrambe le modalità. Come controllo (Pangolin CoV) che segue esclusivamente la 2° via. L'infezione da #Omicron è ben più importante quando la 2° è percorribile. 3/n
Read 10 tweets
I got home this morning after an overnight shift in the pediatric emergency department.

I rarely share personal reflections based on my clinical work as a #pediatrician via @twitter, but I'm allowing myself this exception.

#omicron #COVID19Qc #N95sForAll

A thread 🧵 1/21...
2/ I started my winter holiday stretch of shifts by working on #Christmas evening and finished it by ringing in the #NewYear last night while taking care of sick & injured children with a phenomenal (but overworked & somewhat demoralized team) at the children's hospital.
3/ Let me re-iterate at the outset that I've always been opposed to @francoislegault @coalitionavenir's imposition of the #curfew because of its harmful impacts on many of the most marginalized people in society.
cbc.ca/news/canada/mo…
Read 22 tweets
I was hoping to write up one of those year-in-review pieces for today, but I got caught up with some other posts and never got around to it.

Thank you to everyone who's supported me & my work over the past year (& if you still want to, here's the link!):
acasignups.net/support
I will say this: Between the #OmicronVariant, White Supremacists actively working to eliminate democracy, climate change and other horrors, we're living in dark, ugly times...but I still have hope that decency will survive and prevail.
📣 Speaking of decency surviving and conquering White supremacy & authoritarianism, I'm just $425 away from raising $100K for Dem candidates up & down the ballot! Donate NOW to help keep #HouseBlueIn22! secure.actblue.com/donate/housebl…
Read 6 tweets
Aprender a conviver com o vírus só pode ser proposta de imbecis que ignoram a vida e a saúde como direitos fundamentais.
Exausto de ter que conviver com essa necropolítica!.
Oficialmente, são 619 mil mortos e seguimos aprisionados nesse Brasil paralelo.
#COVID19 #OmicronVariant
Tem pseudojornalista desinformando e disseminando fake news contra as vacinas, as medidas não farmacológicas, e tem negacionista compartilhando essas fake news repletas de pseudociência sem checar qual é a fonte e qual é a origem disso.
#COVID19 #OmicronVariant
O mais grave de tudo é que tem negacionistas sem caráter que acham normal o presidente da República incentivar aglomerações, enquanto se envolvem em aglomerações extremamente desnecessárias, escancarando sua total hipocrisia.
#COVID19 #OmicronVariant
Read 10 tweets
We characterized the structural basis of #SARSCoV2 #OmicronVariant binding to the host ACE2 receptor and neutralization by the S309/sotrovimab clinical antibody therapeutic!

Led by @Dr_MattMcCallum & Nadine Czudnochowski Collab w Gyorgy Snell

1/8

biorxiv.org/content/10.110…
We show that the #OmicronVariant spike NTD antigenic supersite is structurally rearranged, relative to the Wuhan-Hu-1 NTD, explaining the loss of binding and neutralization by a panel of NTD-targeted monoclonal antibodies we recently evaluated (nature.com/articles/d4158…).

2/8
The #OmicronVariant spike S2 subunit (fusion machinery) harbors mutations introducing additional electrostatic contacts with the S1 subunit, which might explain the reduced S1 shedding described in this preprint (biorxiv.org/content/10.110…)

3/8
Read 8 tweets
#OmicronVariant is ramping up is an understatement. Behold a #SARSCoV2 variant unleashed. "Spreading faster than anything we have ever seen before." The novel coronavirus will indeed find more who will be vulnerable to the disease aspect of this virus #COVID19.
Dynamic: many vaccinated believe many incorrect things: 1) You can still get infected. 2) You can still spread it it. 3) Although low %, you can be a breakthrough case. 4) Although low %, you can still succumb to the disease aspect of SARS-CoV-2 infection called COVID-19.
Dynamic: 1) Unvaccinated will be hit comparably to how we got hit year 1 as a fresh, unprotected host. 2) Unvaccinated who still underestimate: your lifestyle is conducive to helping the spread. 3) Asymptomatic spread is real - it is the "stealth" aspect of this coronavirus.
Read 7 tweets
"...our results suggest progenitor of Omicron jumped from humans to mice, rapidly accumulated mutations conducive to infecting that host, then jumped back into humans, indicating an inter-species evolutionary trajectory for the Omicron outbreak." #SARSCoV2
biorxiv.org/content/10.110…
This is exactly what a "Generalist Mammalian" virus looks like. Something is upon us never having been seen before. See pinned Tweet re: Generalist virus.

NIH site says this is peer reviewed now.
This scenario helps explain the many differences in the genome of the #OmicronVariant compared to previous variants, what was baking during Delta's conquest. This will continue and many more scenarios like it. Really, unstoppable, and expect wild new forms of this novel CoV.
Read 5 tweets
28-DEC-2021 UPDATE
1/20

In this 🧵, latest #COVID19 hospitalization data for children 0-17 yrs and adolescents 18-19 yrs, through 27-DEC-2021.
#epitwitter #PedsICU #tweetiatrician #criticalcare #OmicronVariant #longcovidkids

H/T @JasonSalemi
covkidproject.org/hospitalizatio…
28-DEC-2021 UPDATE
2/20

During the 7 days ending 27-Dec, #COVID19 admissions (confirmed diagnosis) totaled 508 adolescents 18-19 years old and 2,305 children 0-17 years old.

covkidproject.org/hospitalizatio…
28-DEC-2021 UPDATE
3/20

Hospital inpatient census of children 0-17 years old with confirmed #COVID19 was 1,146 on Christmas Eve.

covkidproject.org/hospitalizatio…
Read 21 tweets
Ecco uno dei motivi per cui mi sembra surreale la discussione sulle #Quarantene in questi giorni.
Non sappiamo quante quarantene genera un positivo (a fine dicembre 2021!).
Alcuni punti collegati a questo nei tweet seguenti.
1️⃣ molto concreto come sempre @539th. Con molti contatti e la nota infettività di #Omicron potremmo avere quarantene più brevi ma averne tante. Quante? Boh. Ma il rischio di non cambiare nulla o fare pure peggio esiste.

2️⃣ Totalmente assente dal dibattito il fatto che attack rate di #OmicronVariant è maggiore di delta. E sì, su questo ci sono i DATI.

Technical Briefing 33
assets.publishing.service.gov.uk/government/upl…
Read 4 tweets

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