The US markedly lags many countries with boosters, in part because of poor messaging, and lack of priority to get *all* adults with fully restored vaccine effectiveness.
Would help vs Omicron, too. Boosters induce a striking increase in level & breadth of neutralizing antibodies.
Today's @washingtonpost editorial
"The [waning] phenomenon should compel all adults to get a booster shot."
Europe is accelerating 3rd shots ft.com/content/260c3d…
"As of January 10, travellers entering the EU will have to either have received a booster dose or have received their 2nd jab no more than 9 months ago, The EU ... boosters to be recognised in vaccine certificates."
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This is only the 5th Variant of Concern since the pandemic began: Alpha, Beta, Gamma, Delta, and now Omicron.
That it was not named as a Variant of Interest is interesting and raises concern ;-)
There have been thousands of uninteresting #SARSCoV2 variants
Now is not the time to withhold a vital and validated means of boosting our efforts to contain the virus
Each day in the United States, the number of people with waning immunity greatly exceeds those who are getting newly vaccinated. Accordingly, rather than building our wall of population immunity, the United States is suffering attrition.
The UK's path towards improvement as much of Europe is worsening 1. Boosters (3rd shots) are working, as seen by fewer hospital admissions among the age groups receiving them ft.com/content/974487…
2. Infection-acquired immunity playing a role
3, Comparison with many countries throughout Europe experiencing a rapid rise in cases, patients requiring ICU admission and deaths
Just published @ScienceMagazine
The remarkably tight correlation of neutralizing antibody levels with protection from an mRNA vaccine (@moderna_tx) science.org/doi/10.1126/sc…
Titer/Vacccine efficacy
10/78%
100/91%
1000/96%
These are important data, fully concordant with 2 recent studies, reinforcing why boosters are essential and why it is likely that a 3rd dose will be long lasting (1 year or longer) @LancetMicrobe all vaccines, all variants thelancet.com/journals/lanmi…
A 25-50 fold increase in levels of neutralizing antibody of the booster (3rd dose) compared with the 2nd, and more rapidly generated medrxiv.org/content/10.110…
The United States is not taking its 5th major wave seriously.
In November, new cases have increased 30% starting from the high level of 70,000/day. With that hospitalizations and deaths are increasing again.
We haven't taken heed from Europe 4 times theguardian.com/commentisfree/… /1
Our vaccination rate is dangerously low, putting >100 million Americans (40% of 331 M) who are not vaccinated vulnerable. Then there's another 40% who were highly 💉💉protected, but are now out 6 months out and that protection has waned /2
Instead of @CDCgov urging all people who've waned to get a 3rd shot, they deemed them "eligible." Only age 50+ "should" according to their recommendation. That is *not* what the data show and will further diminish our immunity wall /3
First look at the only randomized trial of a booster vaccine data (Pfizer) today cdc.gov/vaccines/acip/…
95% efficacy vs symptomatic infections, consistent across all age, sex, race, ethnicity and comorbid condition subgroups
Benefit seen very early
Side by side event curves for the original Pfizer vaccine trial vs the Booster trial
You can see the curves diverge about a week earlier with a booster, ~14 vs 7 days, which aligns with much faster induction of neutralizing antibodies