Existing vaccines are likely to be significantly less effective against the #OmicronVarient, Moderna’s chief executive has predicted, sounding fresh alarm bells in the financial markets.
Stéphane Bancel expects a “material drop” in the effectiveness of vaccines against the variant because of the high number of mutations in the spike protein, which the virus uses to latch on to human cells.
(C: Scott Eisen)
Of the 50 mutations detected in omicron, 32 are in the spike protein – which the current crop of vaccines target to boost the body’s immune system.
“There is no world, I think, where [the effectiveness] is the same level... we had with [the] delta [variant],” Mr Bancel said.
But, while drug companies including Moderna and Pfizer are already working on omicron-specific vaccines, he warned that it could be months before big pharma can produce these at scale.
Pfizer’s chief executive indicated it’s a campaign that may never end.
“Based on everything I've seen so far,” Dr Albert Bourla said, “I would say that annual vaccinations... are likely to be needed to maintain a very robust and very high level of protection.”
(c: C. Goodney)
The UK has pre-empted this booster-filled next phase, announcing it has bought enough shots for two more per person, with 54 million doses from Pfizer-BioNTech and 60 million from Moderna.
Dr Sharony Cohen said: “[We're] snowed under. It has exploded around here.
“It is very early days... This appears to be very, very infectious, we are inundated with patients.”
“We don’t know what is happening going forward, so this is so stressful – the sheer number.”
Doctors stressed that the mild omicron cases are primarily being found in upper and middle-class neighbourhoods where patients were far more likely to be vaccinated and have access to private healthcare.
Dr Ugur Sahin, a co-founder of BioNTech, said that while the new variant might evade human antibodies, the virus would likely remain vulnerable to attack by T-cells and other parts of the immune system.
“Our message is: Don’t freak out, the plan remains the same: Speed up the administration of a third booster shot,” Dr Sahin said.
Families of people killed in the 9/11 attacks are asking for billions from Afghanistan's seized foreign reserves as damages to settle a court case against the Taliban.
The White House will advise a court this week whether the families should receive some $7bn of Afghan central bank funds locked in the Federal Reserve since the Taliban takeover.
Lawyers for the families say the money now belongs to the Taliban and should therefore form damages under a decade-old court judgment which found the militants liable for helping al-Qaeda.
The humanitarian catastrophe didn't begin with the Taliban's takeover in August.
The country is enduring its second severe drought in 3 years, Covid lockdowns hit the economy hard, and endless war sent hundreds of thousands into camps or urban poverty.
(c: Rahmat Gul)
But the Taliban's stunning victory and the international community's response have pitched the country into economic free fall.
International officials say few countries were so dependent on foreign aid.
Globally, motorbike crashes kill around 380,000 people annually, according to the WHO’s Global Road Safety Status Report from 2018.
Young people are particularly badly affected: road traffic deaths are the leading cause of death among five to 29 year olds around the world
The dangers are even more acute in countries where bikes have boomed in recent decades: in Thailand and Laos, for example, motorbikes are involved in an astonishing 74% of fatal accidents