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Kevin McKernan 🙂 Profile picture
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5 Dec, 4 tweets, 2 min read
Lots of talk about viral recombination this week in light of Omicron.

You know what promotes such things? Image
Quadruplex G formations and degenerate bases.

journals.plos.org/plosone/articl… Image
While I suspect omicron is a directed evolution lab experiment that leaked….

We now have the added complexity of there being patients that have both C19 and the pseudouridine based mRNAs.
Do these recombine/strand switch?
Lots of degenerate bases = more noise in spike.
Here are some notes from the manufacturers showing they have a mess making these mRNAs and trying to express them in cells.

ema.europa.eu/en/documents/v… ImageImageImage

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More from @Kevin_McKernan

Kevin McKernan 🙂 Profile picture
7 Dec
Spike Escape and directed evolution.

For those who missed it.

anandamide.substack.com/p/directed-evo…
For those in need of more evidence…

pubmed.ncbi.nlm.nih.gov/34873910/
Ooops. Image
Read 6 tweets
Kevin McKernan 🙂 Profile picture
25 Nov
When you Warp Speed your codon optimizations and forget to look to at quadruplex G formation.

These mRNA Vaccines should be considered Pro-Drugs, where proof of the final drug is measured, not assumed.
osf.io/bcsa6/
So Molbio folks like to Jack the expression of genes sadly assuming that more is better.

To do this they add strong beta globin promoters and swap the synonymous bases in the codons out with more human like codons.

This is called codon optimization.
There are consequences
First consequence is you tend to shift the GC content of the mRNA significantly when you do this.
36%->61%.

But one should question why your believe the virus ,which is already adapted to its host) needs this tweak?

It doesn’t come risk free.
Read 8 tweets
Kevin McKernan 🙂 Profile picture
10 Nov
I wonder what could go wrong codon optimizing a virus that is already adapted to its host?

What made them think maximum expression was desirable?

Top Track- SARs-CoV-2 GC content over spike.

Bottom- BNT162b2 GC content. Image
They certainly weren’t thinking about secondary structure.

This type of stuff matters to RNAses and other components of the innate immune response (Toll Like Receptors).

Yes, their goal was to evade innate detection with pseudouridine but at what cost? Image
These types of modifications create stop codon ablations and many translation errors.

Has anyone see protein sequence data of the spike protein expressed in vaccinated people?

This seems like a major regulatory oversight.
Read 17 tweets
Kevin McKernan 🙂 Profile picture
1 Nov
ALERT
Is WIV Sloppy with BL4 viruses?

What is Nipahvirus sequence doing in C19 patients sequenced by Wuhan Institute of Virology (WIV)?

This is a BL4 virus far more deadly than C19. Why is it found in patients WIV sequenced and put into NCBI?

Did they really just leak a BL4?
First described here- osf.io/s4td6/

How do we reproduce these claims?

Lets walk through it.
First you need to download the Reads referenced in the paper. PRJNA605983. This is an NCBI accession number for a BioProject that will lead you to many SRR#s related to the samples within the BioProject.
Read 21 tweets
Kevin McKernan 🙂 Profile picture
26 Oct
"We are never going to know how safe the vaccine is in children unless we start giving it".

That's the Wisdom of the FDA review on stabbing your kids with experimental medicine.
Some people thought I made that up.

Straight from the morons lips.

This is after many parents showcased their wheel chair bound kids and that were vax injured & Pfizer refused to acknowledge the injury.

You’re never gonna know because your complicit is not looking at it.
Hey look.
Dr. Ruben has Gates money.

And he’s no idiot being an accomplished scientist and editor at NEJM.

I was hoping I could excuse him as incompetent …but Nope!

He knows actually how to wet that beak.

viableopposition.blogspot.com/2020/05/the-bi…
Read 4 tweets
Kevin McKernan 🙂 Profile picture
23 Oct
I knew in 2020 we were in for it when many people in our field tried to cancel @KyleTurley for suggesting cannabinoids might help for coronaviruses.
What is better than a drug that not only slows the replication of the virus but also boosts the host?

ncbi.nlm.nih.gov/pmc/articles/P…
In retrospect, the same people that called for medically censoring an elite athlete, would soon censor physicians, scientists, economists, musicians, artists and intellectuals

No one is qualified to enough to speak out and dissonants need to be banned from society @joerogan
Drugs we knew the most about were exchanged for experimental mRNA transfections using rare and immuno-ablating pseudouridines (as opposed to native uracil). The therapy is a toxic spike protein at very high copy numbers.

The placebo group was torpedoed
The liability waived.
Read 9 tweets

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