1/ #tweetorial

💠 When an Appendicitis Doesn’t Follow the Rules

➡️ Acute appendicitis is the most common abdominal emergency.

-- Read More: manualofmedicine.com/topics/gastroe…

#medtwitter #meded #foamed
2/

➡️ It occurs when there is obstruction of the appendiceal lumen, from a:

👉 fecalith
👉 tumor
👉 infection
👉 hyperplasia of lymphoid follicles
3/

➡️ Classic symptoms include pain that is initially vague and periumbilical followed by a more localized parietal pain in the right lower quadrant.

➡️ Only 50% of people present with these classic symptoms; in the other 50%, appendicitis can be difficult to diagnosis.
4/

➡️ Patients with congenital abnormalities (midgut malrotation or situs inversus totalis) may present with left-sided abdominal pain.

➡️ Retrocecal appendicitis may cause right upper quadrant pain. Retrocecal appendices are found in 26% to 65% of the population.
5/

➡️ Rarely, patients with acute appendicitis may present with chest pain or epigastric pain.

➡️ Patients with undiagnosed congenital diaphragmatic hernia may have an inflamed appendix in the chest cavity, which would present as chest pain.
6/

➡️ There are three specific patient populations who are more likely to present with atypical pain from appendicitis:

👉 pregnant women
👉 children <5 years of age
👉 elderly patients
7/

➡️ Acute Appendicitis in Pregnant Women

👉 If patients are in the third trimester, the appendix is located higher up in the abdomen, and patients may complain of right flank or right upper quadrant pain.
8/

➡️ Acute Appendicitis in Young Children

👉 Infants may have only lethargy and abdominal distention, while toddlers usually present with vomiting and diarrhea, which may be attributed to a viral syndrome.
9/

➡️Elderly patients may have vague or generalized abdominal pain.They also present to the ED later in the disease course, leading to higher rates of perforation

➡️Studies indicate that the majority of elderly with acute appy will have already perforated by the time of surgery

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More from @ManualOMedicine

Jan 11
1/ #tweetorial

💠 Caustic Ingestions - Key Points

➡️ Serious ingestions can immediately result in perforation, shock, and even death.

➡️ Caustic materials cause tissue injury by chemical reaction.

- Read More : manualofmedicine.com/topics/emergen…

#meded #foamed #medtwitter
2/

➡️ Acids cause coagulative necrosis, which results in a self-limiting burn pattern

➡️ Alkaline materials induce liquefactive necrosis with diffusion into deeper layers of the injured mucosa. Even low concentrations of alkaline ingestion can cause extensive injury.
3/

➡️ Caustic Ingestion can provoke injury from the mouth, the airway, down through the esophagus to the small intestine.

➡️ Long-term complications can lead to strictures and an increased risk of esophageal cancer.
Read 9 tweets
Dec 30, 2021
1/ #tweetorial

💠 Boerhaave Syndrome - Key Points

➡️ Boerhaave syndrome is a spontaneous rupture of the esophagus from barotrauma related to retching or any sudden increase in intraabdominal pressure against a closed glottis.

manualofmedicine.com/topics/gastroe…

#medtwitter #foamed #meded
2/

➡️ Classically, we associate Boerhaave syndrome with Mackler triad:

👉 retrosternal chest pain
👉 vomiting
👉 subcutaneous emphysema
3/

➡️ Boerhaave syndrome should be suspected in any patient who presents with retrosternal chest pain, neck pain, or epigastric pain, especially if it began after an episode of severe retching or bearing down against a closed glottis (weight lifting, defecation, childbirth, etc)
Read 8 tweets
Dec 20, 2021
1/ #tweetorial

💠 Anticipate Bleeding and Reverse Coagulopathies in Liver Failure - Key Points

➡️ Blood clotting in the setting of chronic liver disease is complex and may result in a net prothrombotic or antithrombotic state.

manualofmedicine.com/topics/gastroe…

#foamed #medtwitter
2/

➡️ Favoring bleeding (antithrombotic state) are:

👉 reductions in hepatically produced procoagulant factors (II, VII, IX, and X) and fibrinogen.

👉 thrombocytopenia due to reduced thrombopoietin production, splenic sequestration, and production of antiplatelet antibodies.
3/

➡️ Favoring thromboses (prothrombotic state) are:

👉 reductions in a strong anticoagulant factor (protein C).

👉 increased platelet activation due to elevated von Willebrand factor levels.
Read 10 tweets
Nov 11, 2021
1/ #tweetorial

💠 Aggresive Nitroglycerin Usage in Acute Decompensated Heart Failure (ADHF)

➡️ Diuretics should not be considered first-line therapy in the ED treatment of patients with ADHF.

manualofmedicine.com/topics/cardiol…

#medtwitter #meded #foamed #cardioed #CardioTwitter
2/

➡️ The majority of ED patients who present with ADHF are not volume overloaded. Rather, their pulmonary congestion is due to volume redistribution.

➡️ High-dose nitroglycerin therapy should be initiated early in ADHF, especially in patients who are hypertensive.
3/

➡️ Often, these patients arrive to the ED by ambulance and receive sublingual nitroglycerin therapy (0.4 mg every 5 minutes) during their transport.

➡️ Do not begin a nitroglycerin infusion at a dose less than that provided by the sublingual route.
Read 6 tweets

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