Tuesday COVID meeting updates this week (been holding these ever since the onset of the pandemic)
#1
In a series of 70 consecutive COVID deaths reported at a large Kerala hospital, 69 were unvaccinated, one had received 1 dose vaccine.
That was 98.6% unvaccinated, May-Sept
1/
#1
In a series of 70 consecutive COVID deaths reported at a large Kerala hospital, 69 were unvaccinated, one had received 1 dose vaccine.
That was 98.6% unvaccinated, May-Sept
1/
This data is powerful evidence that vaccination has made a significant reduction in the severe outcomes of delta.
Remember, these are vaccines based on the old Wuhan strain of the SARS-CoV-2 virus.
Yet they are protective against delta variant.
This is hard evidence.
2/
Remember, these are vaccines based on the old Wuhan strain of the SARS-CoV-2 virus.
Yet they are protective against delta variant.
This is hard evidence.
2/
This is real-world evidence that vaccine protection (against severe disease, mainly cell mediated immunity) kicks in with the first dose itself.
In fact we know from lab studies that T cells arrive by day 10 after the first dose.
Let me explain the immunology.
3/
In fact we know from lab studies that T cells arrive by day 10 after the first dose.
Let me explain the immunology.
3/
After the initial “excitement” (introduction of components of virus by vaccination), a few of these T cells retire and become memory cells that live in the tissues and elsewhere.
Retirement also occurs in B cells (antibody factory), where a few live ~forever as memory cells.
4/
Retirement also occurs in B cells (antibody factory), where a few live ~forever as memory cells.
4/
These memory cells of B & T cell genre sniff out the earliest presence of the virus if & when an infection occurs. They make sure that a strong, systematic, prompt response is mounted.
That is how organ damage is prevented. It doesn’t matter what variant it is, see the data.
5/
That is how organ damage is prevented. It doesn’t matter what variant it is, see the data.
5/
Many people panic when they hear words like “neutralising titer drops by 40 fold” etc. That is why we must look at the big picture.
Let’s not forget the same “drop of neutralising titre” was the worry of the world ever since delta arrived.
6/
Let’s not forget the same “drop of neutralising titre” was the worry of the world ever since delta arrived.
6/
We doctors are carefully monitoring the situation to look for any changes in trends.
So far there is no cause for any alarm with vaccines failing.
(Asymptomatic breakthrough infections are expected within a few months after vaccine, that is not the same as severe disease)
7/
So far there is no cause for any alarm with vaccines failing.
(Asymptomatic breakthrough infections are expected within a few months after vaccine, that is not the same as severe disease)
7/
Will post other updates later.
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